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Method for preparing ellagic acid from heated terminalia chebula pulp and application

A technology for making chebula meat and chebula meat, which is applied in the field of medicine, can solve the problems of high resin technology requirements, complicated operation methods, and long production cycle, and achieve the effects of difficult cure, improved quality of life, and increased yield

Active Publication Date: 2020-02-11
LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although this method can produce high-purity ellagic acid products, the operation is relatively complicated and the technical requirements for the resin are relatively high.
A method for preparing ellagic acid from chebula chebula (CN102020682B). Taking the coarse powder of chebula leaves, and preparing ellagic acid through microwave extraction and multiple ion exchange resin adsorption and elution, the operation method is complicated, the yield is low, and the production cycle is long , not suitable for industrial production

Method used

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  • Method for preparing ellagic acid from heated terminalia chebula pulp and application
  • Method for preparing ellagic acid from heated terminalia chebula pulp and application
  • Method for preparing ellagic acid from heated terminalia chebula pulp and application

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Embodiment 1

[0038] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments. However, it should not be understood that the scope of the above subject matter of the present invention is limited to the following embodiments, and all technologies realized based on the content of the present invention belong to the scope of the present invention. Example 1 Process optimization experiment of the method for preparing ellagic acid from the meat of Myrobalan.

[0039] 1. The preparation method of sanded Myrobalan meat-processing temperature screening experiment.

[0040] A method for preparing chebula meat, comprising the following steps.

[0041] (1) Take 9 parts of myrobalan (containing ellagic acid 1.572%), 20g each, and place them at 180°C, 190°C, 200°C, 210°C, 220°C, 230°C, 240°C, 250°C, 260°C In the river sand, they were all scalded for 6 minutes, and the pulp was peeled off.

[0042] (2) Take each portion of che...

Embodiment 2

[0105] Example 2 Pharmacological research experiment of ellagic acid-Using dextran sodium sulfate (DSS) modeling method to reproduce the mouse ulcerative colitis model.

[0106] Get 90 mice, be randomly divided into blank group, model group, positive drug group and method 6~11 groups in embodiment 1, every group 10, after freely drinking 4% DSS aqueous solution 4 days (blank group drinking water), blank group The group and the model group were administered with normal saline by intragastric administration, the positive drug group was administered with sulfasalazine aqueous solution, and each embodiment group was administered with the obtained ellagic acid product by intragastric administration, and the ellagic acid product obtained by methods 6 to 11 in Example 1 The concentration of ellagic acid is about 1.7mg·ml -1 solution, the dosage is calculated by gavage of 0.1ml per 10g of body weight, and administered for 7 days. The mice were sacrificed 4 hours after the last admini...

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Abstract

The invention relates to the technical field of traditional Chinese medicine processing and natural product extraction, in particular to a method for preparing ellagic acid from terminalia chebula pulp processed through being heated by sand and application. The method of preparing the ellagic acid comprises the following steps of putting the terminalia chebula fruits into river sand being 220 DEGC to 260 DEG C; performing heating for 5 to 9 min; peeling pulp; crushing the pulp into medicine powder; performing reflux extraction by ethanol; then, performing gradient elution by the ethanol at different concentrations by using a macroporous adsorption resin method; collecting eluent with the ethanol concentration being 90 percent; recovering the ethanol; and drying residues at reduced pressure to obtain an ellagic acid product. Through the optimization on a processing method and process parameters, the content of the ellagic acid in raw materials is greatly improved; and through the reflux extraction through the ethanol, and then through elution through ethanol solutions by the macroporous adsorption resin method, the cost is effectively reduced, and the yield and the purity of the ellagic acid product are improved. The ellagic acid prepared by the method is used for treating ulcerative colitis, is safe and effective, and is favorable for improving the life quality of patients.

Description

technical field [0001] The invention belongs to the technical field of medicine, relates to the technical field of processing traditional Chinese medicines and extracting natural products, and in particular relates to a method and application for preparing ellagic acid from processed chebula meat. Background technique [0002] Ellagic acid, also known as gallic acid, is a dimeric derivative of gallic acid, which is widely found in various plant fruits. Natural ellagic acid was first found in plants such as raspberries, chestnuts, and pomegranates. Modern pharmacological studies have found that ellagic acid has a variety of biological activities. First of all, it has an obvious inhibitory effect on chemical substance-induced cancer and other cancers, especially colon cancer, esophageal cancer, liver cancer, lung cancer, tongue and skin cancer, and is known as the guardian of the human body. At the beginning of this century, the Brookings Cancer Institute in the United State...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P1/04A61K131/00
CPCA61K36/185A61P1/04A61K2236/333A61K2236/55A61K2236/51
Inventor 王巍鞠成国张强温聪聪杜春洁
Owner LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
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