Polydopamine film as well as preparation method and application thereof

A polydopamine film and reaction technology, applied in the application field of medical implant materials, can solve problems such as corrosion, depolymerization and film dissolution, loading problems, etc., and achieve the effects of simplifying steps, promoting synthesis, and shortening time

Active Publication Date: 2020-02-25
B J ZH F PANTHER MEDICAL EQUIP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the ammonia solution of sulfadiazine silver is corrosive to the polydopamine film, especially ammonia water can cause the depolymerization and film dissolution of the polydopamine film; further, the catalyst trifluoromethanesulfonic acid or trifluoromethanesulfonate will There is a certain amount of attachment and binding on the polydopamine film, and it competes with silver sulfadiazine for the attachment site, and trifluoromethanesulfonic acid or trifluoromethanesulfonate also has certain toxicity, so it is not suitable for the field of medical devices; the above Reasons that make the loading of silver sulfadiazine on the surface of biomedical implant materials a problem

Method used

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  • Polydopamine film as well as preparation method and application thereof
  • Polydopamine film as well as preparation method and application thereof
  • Polydopamine film as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] 1. Preparation of polydopamine coating:

[0058] 1.1 The cleaned pure titanium medical implant material is irradiated under ultraviolet light for 1 hour, then soaked in a pH 8.5 solution containing 2g / L dopamine monomer Tris-HCL, and then added with a final concentration of 10mg / L calcium peroxide, Immediately after putting the reaction flask containing the mixed solution into the body cavity of a temperature-controlled focused microwave synthesizer, react at a constant temperature of 25°C for 3 minutes with a microwave power of 300W, and a dense polydopamine film can be obtained on the surface of the implant. Take out and repeat ultrasonic washing and rinse with deionized water and dry with nitrogen.

[0059] 1.2 does not repeat 1.1. The polydopamine film is a single layer.

[0060] 2. In-situ synthesis of silver sulfadiazine on conventional polydopamine film

[0061] 2.1 Put the treated material in 1.2 in a solution of sulfadiazine (20mmol / L) in sodium hydroxide (20mmol / L),...

Embodiment 2

[0064] 1. Preparation of polydopamine coating:

[0065] 1.1 The cleaned titanium alloy (TI-6AL-4V) medical implant material is irradiated under ultraviolet light for 6 hours, then immersed in a pH 7.1 solution containing 1g / L dopamine monomer Tri-HCL, and then added to a final concentration of 20mg / L calcium peroxide, immediately put the reaction flask containing the mixture into the body cavity of the temperature-controlled focused microwave synthesizer, and react at 65°C for 5 minutes with a microwave power of 100W. The dense layer of polydopamine film is taken out and washed repeatedly with ultrasonic and rinsed with deionized water, and dried with nitrogen.

[0066] 1.2 Repeat step 1.1 4 times. Finally, the polydopamine film has 5 layers.

[0067] 2. In-situ synthesis of silver sulfadiazine on conventional polydopamine film

[0068] 2.1 Put the treated material in 1.2 in a solution of sulfadiazine (30mmol / L) in sodium hydroxide (45mmol / L), pH 8.7, so that the molar ratio of sul...

Embodiment 3

[0071] 1. Preparation of polydopamine coating:

[0072] 1.1 The cleaned titanium alloy (Ti-25nb-10ta-1zr-0.2fe) medical implant material is irradiated under ultraviolet light for 12 hours, and then immersed in a pH 8.0 Tri-HCL solution containing 3g / L dopamine monomer. Then add calcium peroxide with a final concentration of 40mg / L, and immediately put the reaction flask containing the mixed solution into the body cavity of the temperature-controlled focusing microwave synthesizer, and react at a constant temperature of 50°C for 11 minutes with a microwave power of 100W. A layer of dense polydopamine film is obtained on the surface of the object, which is taken out and washed repeatedly with ultrasonic and rinsed with deionized water and dried with nitrogen.

[0073] 1.2 Repeat step 1.1 9 times. The polydopamine film has 10 layers.

[0074] 2. In-situ synthesis of silver sulfadiazine on conventional polydopamine film

[0075] 2.1 Put the treated material in 1.2 in a solution of sulfa...

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Abstract

The invention discloses a polydopamine film as well as a preparation method and an application thereof. The polydopamine film is loaded with sulfadiazine silver. According to the preparation method, in-situ synthesis of sulfadiazine silver on the conventional polydopamine film is realized through microwave irradiation. In the method, the sulfadiazine does not need to be dissolved by the traditional ammonia water, so that the method has the following advantages: firstly, the corrosion effect of the ammonia water on the polydopamine film can be avoided; secondly, stimulation and corrosion of theammonia water to mucous membranes such as eyes and nasal cavities of a worker can be avoided; and thirdly, the environmental problem caused by pungent smell smoke volatilized by the high-concentration ammonia water can be avoided. In the method, a catalyst trifluoromethanesulfonic acid or trifluoromethanesulfonate is not used, so that the loading capacity of sulfadiazine silver can be improved, and the safety performance can be further improved.

Description

Technical field [0001] The invention relates to a polydopamine film and a preparation method and application thereof, in particular to a polydopamine film loaded with silver sulfadiazine, which is prepared by in-situ synthesis of silver sulfadiazine on a conventional polydopamine film by microwave irradiation to prepare the polydopamine The film method and the application of the polydopamine film in medical implant materials. Background technique [0002] At present, when implanting biomedical implant materials in surgical operations, the possible infection is still a very difficult problem facing the clinic. Although biomedical implant materials such as inorganic materials, organic materials and metals and their alloy materials (such as ceramics, polymer materials, stainless steel, pure titanium and its alloys, and pure magnesium and its alloys, etc.), due to their excellent mechanical properties and With good biocompatibility, it has been widely used in the repair of hard tiss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/10A61L31/02A61L31/08A61L31/16
CPCA61L31/10A61L31/16A61L2300/104A61L2300/404C08J7/065C07D239/42A61L31/14C08J2379/04C08L79/02A61B17/11A61B2017/00893A61B2017/0647A61L2420/02B05D1/18B05D3/06C08J5/18C08J2379/02C08K5/3462
Inventor 刘青蒲丛
Owner B J ZH F PANTHER MEDICAL EQUIP
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