Thioformamide, and preparation method and application thereof

Abstract

The invention discloses a thioformamide, and a preparation method and an application thereof. Carbon disulfide and formamide which are used as raw materials are reacted under a pressure of 3-5 MPa under the catalytic action of an organic alkali to generate thioformamide, and the thioformamide is rectified and collected after the reaction is finished. The thioformamide prepared in the invention canbe used as an thiabendazole intermediate to synthesize thiabendazole which is applied to the fields of sterilization, corrosion prevention, fresh keeping and the like. The preparation method has theadvantages of simplicity, mild reaction conditions, safety, controllability, low production cost, high yield, no generation of wastewater or toxic gases, and reduction of environmental pollution.

Description

technical field [0001] The invention relates to the field of chemical material synthesis, in particular to thioformamide, a preparation method of thioformamide and the application of thioformamide as a thiabendazole intermediate. Background technique [0002] Thioformamide is the key intermediate of thiabendazole and also an important fine chemical product. [0003] At present, the synthesis process of thioformamide is to react with formamide and phosphorus pentasulfide as raw materials. During the reaction, impurities such as phosphorus pentoxide are easily formed to adhere to the wall, forming impurities, which is not conducive to the reaction; moreover, the reaction system often uses tetrahydrofuran (THF) as a solvent, tetrahydrofuran is expensive on the one hand, and the cost is higher; on the other hand, it is necessary to ensure a completely anhydrous environment, and the THF drying process is more complicated and difficult. In short, the synthesis process has low yie...

AI Technical Summary

Problems solved by technology

[0003] At present, the synthesis process of thioformamide is to react with formamide and phosphorus pentasulfide as raw materials. During the reaction, impurities such as phosphorus pentoxide are easily formed to adhere to the wall, forming impurities, which is not conducive to the reaction; moreover, the reaction system often uses tetrahydrofuran (THF) is used as a solvent. On the one hand, tetrahydrofuran is expensive and the cost is high; on the other hand, it is necessary to ensure a completely anhydrous environment. The drying process of THF is complicated and difficult

In short, the synthesis process has low yield, high production cost, large consumption of raw materials, and produces a large amount of phosphorus-containing wastewater and toxic hydrogen sulfide gas. The production process is unsafe, unfavorable to the environment, and the environmental protection disposal cost is extremely high.

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