A kind of synthetic method of naringin dihydrochalcone

A technology of naringin dihydrochalcone and a synthesis method is applied in the field of synthesis of intermediate product naringin dihydrochalcone, and can solve the problem that no safe, non-toxic phloridzin synthesis process, toxic reaction, load It can solve the problem of high volume, and achieve the effects of easy access, environmental protection of solvents, and rich sources.

Active Publication Date: 2021-12-14
SHAANXI JIAHE PHYTOCHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] 5. The activity of the brain consumes a large amount of energy supplied by glucose. Many evidences prove that the level of circulating blood sugar controls the process of learning and memory. Many drugs that improve memory function are related to the release of liver glycogen, increasing the level of blood sugar in the brain and utilizing it. Ability-related
Among them, the resin adsorption method has large adsorption capacity, good selectivity, easy desorption, high mechanical strength, simple regeneration treatment, fast adsorption speed, and no pollution to the environment, but the toxicity of the pore-forming agent used in the preparation of macroporous resins is problematic. Has been the focus of controversy in this technology, which has become an obstacle to the separation of phlorizin by macroporous resin adsorption technology
Polyamide chromatography column separation method is simple to operate, good separation effect, high loading capacity, and less non-specific adsorption. The disadvantage of this method is that methanol, which is moderately toxic to the human body, is used as the eluent during the elution process. The nervous system and blood system of the human body are greatly affected, and it will produce toxic reactions when ingested into the human body through the digestive tract, respiratory tract or skin
No safer, non-toxic phlorizin synthesis process has been found so far

Method used

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  • A kind of synthetic method of naringin dihydrochalcone

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] A kind of synthetic method of naringin dihydrochalcone, is characterized in that, comprises the following steps:

[0036] 1) Preparation of crude wet product of naringin dihydrochalcone

[0037] 1.1) 10g of raw material naringin was dissolved in 100g of 5% sodium hydroxide solution, then 0.7g of Raney nickel catalyst was added, placed at room temperature, hydrogenation reaction was carried out under 0.5Mp hydrogen pressure for 1.5h, liquid Monitor the reaction until the content of naringin dihydrochalcone is 97-98%, and stop the reaction to obtain a reaction liquid;

[0038] 1.2) Filter the reaction liquid obtained in step 1), remove the catalyst, cool down to 0-5°C, and add 12g of concentrated hydrochloric acid to adjust the pH of the reaction liquid to 4-5; then raise the temperature to 5-10°C, keep it warm for 4 hours, and use a plate and frame press Filtration, obtained naringin dihydrochalcone thick wet product 19g;

[0039] 2) Preparation of naringin dihydrochal...

Embodiment 2

[0043] A kind of synthetic method of naringin dihydrochalcone, is characterized in that, comprises the following steps:

[0044] 1) Preparation of crude wet product of naringin dihydrochalcone

[0045] 1.1) 50g of raw material naringin was dissolved in 500g of 5% sodium hydroxide solution, then 3.5g of Raney nickel catalyst was added, placed at room temperature, hydrogenation reaction was carried out under 0.5Mp hydrogen pressure for 1.5h, liquid Monitor the reaction until the content of naringin dihydrochalcone is 97-98%, and stop the reaction to obtain a reaction liquid;

[0046]1.2) Filtrate the reaction solution obtained in step 1), remove the catalyst, cool down to 0-5°C, and add 60g of concentrated hydrochloric acid to adjust the pH of the reaction solution to 4-5; then heat up to 5-10°C, keep it warm for 4 hours, and then use a plate and frame press Filter, and make naringin dihydrochalcone rough wet product 98g;

[0047] 2) Preparation of naringin dihydrochalcone bou...

Embodiment 3

[0051] A kind of synthetic method of naringin dihydrochalcone, is characterized in that, comprises the following steps:

[0052] 1) Preparation of crude wet product of naringin dihydrochalcone

[0053] 1.1) Dissolve 30g of raw material naringin into 300g of 5% sodium hydroxide solution, then add 2.1g of Raney nickel catalyst, place at room temperature, carry out hydrogenation reaction under 0.5Mp hydrogen pressure for 1.5h, liquid Monitor the reaction until the content of naringin dihydrochalcone is 97-98%, and stop the reaction to obtain a reaction liquid;

[0054] 1.2) Filter the reaction liquid obtained in step 1), remove the catalyst, cool down to 0-5°C, and add 36g of concentrated hydrochloric acid to adjust the pH of the reaction liquid to 4-5; then raise the temperature to 5-10°C, keep it warm for 4 hours, and use a plate and frame press Filter to obtain naringin dihydrochalcone rough wet product 59g;

[0055] 2) Preparation of naringin dihydrochalcone boutique

[00...

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Abstract

The invention provides a method for synthesizing naringin dihydrochalcone, which is safer, simpler and non-toxic. The present invention uses naringin as a starting material, puts it in lye for ring-opening catalytic hydrogenation, and purifies it to prepare the refined naringin dihydrochalcone.

Description

technical field [0001] The invention belongs to the technical field of food additives, in particular to a method for synthesizing an intermediate product, naringin dihydrochalcone. Background technique [0002] Phlorizin is a glycoside composed of phloretin and glycosides as glucosides. It belongs to the dihydrochalcone substances in flavonoids. The sugar base is hydrolyzed to form glucose. In addition, the content is high, and it is considered by many scholars to be carbohydrates. a form of storage. Phlorizin is extracted from apples, apple bark and leaves, etc. It is a phenolic substance in the apple tree. Studies have shown that phlorizin accounts for 95% of the total content of phenolic substances in the apple tree. The content is so high that its existence state can affect the overall existence state of classified substances, and its degradation product, phlorobarkol, has the effect of effectively inhibiting microbial activities. [0003] Phlorizin has many advantages...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P19/44C07H15/203C07H1/00C07H1/06
CPCC12P19/44C07H15/203C07H1/00C07H1/06
Inventor 郭文华肖金霞赵景辉
Owner SHAANXI JIAHE PHYTOCHEM
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