Floatable pharmaceutical microcapsule composition

A technology of microcapsules and drugs, applied in the direction of drug combination, microcapsules, and capsule delivery, which can solve problems such as drug-resistant TB
CN110996925AInactive Publication Date: 2020-04-10NANYANG TECH UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NANYANG TECH UNIV
Publication Date
2020-04-10
Estimated Expiration
Not applicable · inactive patent

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Abstract

Disclosed herein is a sustained release hollow core-shell microcapsule formulation for drug delivery comprising a hollow shell of one or more hydrophobic polymers, a drug containing hydrophilic or amphiphilic carrier matrix that is distributed over the inner surface of the hollow shell, a flotation agent, and an optional osmotic agent, wherein the microcapsule is capable of floating in a simulateddigestive fluid for a period of from 24 to 96 hours. The microcapsules are prepared by a modified double emulsion (water / oil / water) solvent evaporation method. The microcapsule formulation may provide a sustained-release delivery system for treating chronic diseases such as Parkinson's disease, diabetes and tuberculosis, all of which require multiple drug combination therapies. The aim is to reduce dosing frequency and pill burden, thus improving patient medication compliance. In a specific embodiment, the hollow shell is formed from a mixture of Poly-L-lactide (PLLA) and poly(E-caprolactone)(PCL); and the amphiphilic carrier matrix is casein.
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Description

technical field

[0001] The present invention relates to gastric floating microcapsules for trapping one or more, preferably multiple, drugs and methods for their manufacture. Background technique

[0002] The listing or discussion in this specification of a document which is apparently prior published does not necessarily constitute an admission that the document is part of the prior art or is common general knowledge.

[0003] Parkinson's disease (PD) is a degenerative disorder of the central nervous system that causes asymmetric episodes of bradykinesia, resting tremor, muscle rigidity, and postural instability. It is more common in older adults, with most cases occurring after the age of 50. Early signs and symptoms may be mild and may go unnoticed at first, but the symptoms of this motor degenerative disease stem from the death of dopamine-producing cells in the substantia nigra — an area of ​​the midbrain.

[0004] Although the etiology of Parkinson's disease remains ...

Claims

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