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Method for synthesizing MoO3-X antibacterial material with dual mimic enzyme activity

A synthesis method and technology of antibacterial materials, which are applied in the field of synthesizing MoO3-X antibacterial materials with dual enzymatic activity, can solve the problems of no enzymatic activity, carbonization of reductant, and reduction of water solubility, etc., to improve yield and Biocompatibility, easy sterilization, large contact area effect

Pending Publication Date: 2020-04-17
QINGDAO UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, reduced molybdenum oxide MoO synthesized by existing methods 3-x Only have photothermal and photosensitive properties (ACS Appl. Mater. Interfaces, 2018, 10 (49), 42088-42101; Nanoscale, 2018, 10, 1517; Nanoscale, 2018, 10, 5997; Sensors and Actuators B, 2018, 259, 59 -63), without mimic enzyme catalytic activity
Currently MoO 3-x Usually by ultrasonic MoS 2 Nanosheets or high-temperature hydrothermal reduction of molybdate (Small 2018, 14, 1801523; Sensors and Actuators B: Chemical, 2019, 296, 126517; Applied Catalysis B: Environmental, 2018, 224, 671-680), the yield of the ultrasonic method is low, High-temperature hydrothermal is easy to carbonize the reducing agent and reduce its water solubility, these problems limit the MoO 3-x biological applications

Method used

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  • Method for synthesizing MoO3-X antibacterial material with dual mimic enzyme activity
  • Method for synthesizing MoO3-X antibacterial material with dual mimic enzyme activity
  • Method for synthesizing MoO3-X antibacterial material with dual mimic enzyme activity

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Embodiment 1

[0034] A kind of synthetic method of the molybdenum oxide antibacterial material with double imitating enzyme activity provided in this embodiment, comprises the following steps:

[0035] S1. Dissolving glucose in water, stirring to dissolve, adding molybdate, and continuing to stir until the molybdate is completely dissolved to obtain a mixed solution;

[0036] S2, adding hydrochloric acid to the mixed solution prepared in S1, adjusting the pH of the mixed solution to be acidic;

[0037] S3. Pour the uniformly stirred mixed solution in S2 into a reaction kettle with a tetrafluoroethylene liner, seal it, and heat it to obtain a blue solution;

[0038] S4. Dialyze the blue solution with a dialysis bag, and freeze-dry the remaining material after dialysis to obtain nano-MoO 3-X Antibacterial material, sealed and stored away from light.

[0039] Preferably, the mass volume ratio of glucose to water in this embodiment S1 is 0.3-2.0 g: 30 mL.

[0040] Preferably, the mass ratio ...

Embodiment 2

[0047] S1. Dissolve 1.5g glucose and 0.5g ammonium molybdate in 30mL water, stir for 20 minutes until completely dissolved;

[0048] S2. Add hydrochloric acid dropwise to the mixed solution, adjust the pH of the solution to be 4, and then stir for 5 minutes;

[0049] S3, pour the mixed solution into a tetrafluoroethylene reactor and seal it, and heat it at 80 degrees for 12 hours;

[0050] S4. The crude product is poured into a dialysis bag (10Kda dialysis membrane), dialyzed for 48 hours, then freeze-dried, sealed and stored away from light.

Embodiment 3

[0052] Basically the same as embodiment 2, the difference is:

[0053] In the step S1, the mass volume ratio of glucose to water is 1.2g:30mL;

[0054] Described, the mass ratio of glucose and sodium molybdate is 3:1;

[0055] In the step S2, the mixed solution has a pH of 1 and is stirred for 15 minutes;

[0056] In the step S3, the hydrothermal reaction temperature is 80 degrees, and the reaction is carried out for 6 hours.

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Abstract

The invention belongs to the field of combination of inorganic nano material preparation and mimic enzyme technology, and relates to a preparation method of an antibacterial material, particularly toa method for synthesizing a MoO3-X antibacterial material with dual mimic enzyme activity. The preparation process comprises the following steps: completely dissolving glucose powder in water, and adding an acid to adjust and dissolve so as to achieve an acidic pH value; sealing and heating to obtain a dark blue solution; and carrying out dialysis on the dark blue solution, and carrying out freezedrying to obtain the nano MoO3-X material. According to the invention, the reduction-state molybdenum oxide nano material prepared by the invention is applied to double mimic enzyme catalytically-synergetic drug-resistant bacterial resistance; according to the severe situation of drug-resistant bacteria and biological membrane treatment, the key technical problem of preparation of the nano MoO3-Xantibacterial agent with high yield, good biocompatibility, high near-infrared photothermal conversion efficiency and high dual-enzyme-imitating activity is solved through the environment-friendly, simple and efficient one-step hydrothermal method; and the application environment is friendly and the market prospect is wide.

Description

Technical field: [0001] The invention belongs to the field of combining inorganic nanomaterial preparation and imitation enzyme technology, and relates to a preparation method of an antibacterial material, in particular to a method for synthesizing MoO with double imitation enzyme activity 3-X Methods for antimicrobial materials. Background technique: [0002] With the development of nanotechnology, the study of nano-mimetic enzymes has gradually become a research hotspot. Compared with natural enzymes, nanozymes have the characteristics of stability, economy, high catalytic efficiency and large-scale preparation. Since Fe3O4 was first reported to have peroxidase properties in 2007, more and more inorganic nanoparticles have been found to have enzyme-mimicking properties, such as gold, silver, carbon nanotubes, quantum dots, manganese dioxide Wait. The discovery of these mimic enzymes has greatly expanded the scope of application of enzymes. At present, more researches a...

Claims

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Application Information

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IPC IPC(8): C01G39/02B82Y30/00B82Y40/00A61K41/00A61K33/24A61K33/40A61P31/04
CPCC01G39/02A61K41/0052A61K41/0057A61K33/40A61K33/24A61P31/04B82Y30/00B82Y40/00A61K2300/00
Inventor 李爱华许元红马伟帅
Owner QINGDAO UNIV
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