Biological cascade reaction type photodynamic integrated biopolymer, preparation method and applications thereof

Abstract

The invention relates to a biological cascade reaction type photodynamic integrated biopolymer, a preparation method and applications thereof, and belongs to the field of medicine preparation. According to the biological cascade reaction type photodynamic integrated biopolymer (PEG4000-CDM-ZnPc-S-S-HA), a photosensitizer zinc phthalocyanine (ZnPc) and PEG 4000 are combined through a pH-acid responsive maleic acid amide linker; and the combined material is immobilized on a hyaluronic acid (HA) chain by using a disulfide linker capable of being cracked by oxidation reduction, wherein the PEG segment can enhance the blood circulation of a molecular carrier after intravenous administration to fall off after reaching an acidic tumor microenvironment, so that the residual ZnPc-S-S-HA is self-assembled into a large cluster in situ so as to avoid reverse diffusion and improve the tumor retention rate, and due to hydrophilicity, degradability and the capacity of specifically combining with CD44overexpressed on a tumor cell membrane, HA is used as a carrier substrate and a tumor targeting ligand.

Description

Technical field [0001] The invention belongs to the field of medicine preparation, and specifically relates to a biological cascade reaction type photodynamic integrated biopolymer and a preparation method and application thereof. Background technique [0002] The size of nanomaterials is a key factor in determining the mode of interaction between nanomaterials and the biological environment, and may fundamentally affect their functional performance in clinical applications. From a clinical point of view, large-size nanoparticles (20-200nm) usually show better tumor aggregation effects due to the enhanced penetration and retention (EPR) effect, while small-size nanoparticles ( <10nm) Due to better diffusion fluidity, it often has a strong tumor penetration ability. The emergence of supramolecular nanotechnology provides new opportunities to combine the advantages of large and small nano-biological materials, the most common of which is to use the self-assembly of nanoparticles...

AI Technical Summary

Problems solved by technology

However, its clinical translation is hampered by a series of issues related to the delivery and actuation of light-activated photosensitizers (PS), which are usually highly hydrophobic and tend to aggregate in aqueous environments, leading to rapid clearance and self-quenching; An optimal PDT nanoformulation strategy should be highly tumor-specific during systemic redistribution while being able to deliver PS molecules in a single-molecule manner after tumor uptake.

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