High-biosafety heart stent and manufacturing method thereof

A biosafety and heart stent technology, which is applied in pharmaceutical formulation, drug delivery, medical science, etc., can solve problems affecting the blood compatibility of the stent, insufficient biosafety, and insufficient strength of the stent, so as to improve blood compatibility , Improve the strength and hydrophilicity, and the effect of excellent degradation performance
CN111110929AActive Publication Date: 2020-05-08SHENZHEN MEDOO MEDICAL TECH
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
SHENZHEN MEDOO MEDICAL TECH
Publication Date
2020-05-08

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Abstract

The invention discloses a high-biosafety heart stent and a manufacturing method thereof. The method comprises the following steps: preparing polylactic acid by a lactide ring-opening polymerization approach, mixing and sintering nano calcium phosphate and magnesium oxide to prepare an inorganic filler, blending polylactic acid, polyethylene glycol and the inorganic filler to prepare printing slurry, forming a heart stent structure through 3D printing, and carrying out freeze drying and dipping drug loading to obtain the heart stent with high biosafety. According to the method, the molecular weight of the polylactic acid can be adjusted, so that the polylactic acid has excellent mechanical property and degradation property at the same time; the strength of the prepared heart stent is effectively improved by utilizing the synergistic effect of polylactic acid, inorganic filler and polyethylene glycol, and the heart stent has a proper degradation rate and relatively high biological safety. In addition, the prepared high-biosafety heart stent has high radial strength, proper porosity and degradation time, and can meet the requirements of practical application.
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Description

Technical field

[0001] The invention relates to the technical field of heart stents, in particular to a heart stent with high biological safety and a manufacturing method thereof. Background technique

[0002] Cardiac stents are commonly used medical devices in cardiac interventional operations, which have the function of dredging arteries and are often used in the treatment of coronary heart disease. At present, heart stents are mainly divided into three types: metal stents, drug-coated stents and bioabsorbable stents. Among them, traditional metal stents and drug-coated stents cannot be completely degraded and will permanently exist in the blood vessel, which is likely to cause chronic damage to the blood vessel and intimal hyperplasia, and the risk of intrastent thrombosis and restenosis in the stent increases. High; and the bioabsorbable stent can dissolve in the body after the stent function is completed and be absorbed by the body, thereby avoiding the adverse consequences...

Claims

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