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Preparation method of modified starch and application

A modification and starch technology, which is applied in the directions of biochemical equipment and methods, applications, and medical preparations containing active ingredients, etc. problems, to achieve the ideal hypoglycemic effect, regulate body weight and blood lipids, and achieve the effect of high content

Inactive Publication Date: 2020-05-19
QILU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The acid hydrolysis method is likely to cause environmental pollution due to the use of a large amount of acid and alkali, and the yield of resistant starch prepared by the autoclave method is low. The existing enzymatic hydrolysis method usually only uses pullulanase to remove the branched chain structure of the starch, and a limited amount can be obtained. The linear chain of the longer chain segment, and then prepare the resistant starch by cooling the entanglement between the molecular chains, the yield is not high, and the content of the resistant starch drops to even lower after cooking, suggesting that the growth rate cannot be satisfied. industrial production requirements

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  • Preparation method of modified starch and application
  • Preparation method of modified starch and application
  • Preparation method of modified starch and application

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preparation example Construction

[0034] The invention provides a method for preparing modified starch: adding β-amylase to the starch gelatinization solution for modification, adding branching enzyme to continue the modification after deactivating the enzyme, adding pullulan enzyme to continue the modification after deactivating the enzyme, and deactivating the enzyme Afterwards, the enzymatic hydrolyzate is precipitated with alcohol, and the precipitate is dried to obtain modified starch.

[0035] The source of starch gelatinization liquid can be edible starch such as rice starch, potato starch, yam starch, banana starch. β-amylase from barley (BA, EC 3.2.1.2), branching enzyme from Rhodothermus obamensis (BE, EC 2.4.1.18) and pullulanase from Pullulan solutes nagano (PUL, EC 3.2.1.41 ) to modify the molecular chain structure of starch, and other reagents are commercially available.

[0036] The RS content of natural rice starch is extremely low, but Chinese people eat it more often. Using the rice starch t...

Embodiment 4

[0071] 200mg resistant starch, 36mg GSPA S , 135mg microcrystalline cellulose, 4mg magnesium stearate, and 20mg cross-linked polyvinylpyrrolidone are fully mixed, and the 10% polyvinylpyrrolidone solution prepared in 50% ethanol solution is used as a binder to make a soft material. Experience "Hold it into a ball, pinch it and break it";

[0072] Granulation: sieve the soft materials to make wet granules;

[0073] Dry the wet granules, set the drying temperature to 45°C, gradually raise the temperature to 60°C, and dry until the moisture content of the granules is 2%;

[0074] Grain sizing: the dried granules are sieved to obtain granules with suitable particle size;

[0075] Tablet compression: After granulation, add 2-4% magnesium stearate to the granules by external addition method, mix evenly, adjust the pressure of the tablet machine, fill the granules into the tablet mold for tablet compression;

[0076] Inspection: Check the tablet appearance, tablet weight differenc...

Embodiment 5

[0079] 150mg resistant starch, 30mg GSPA S , 150mg microcrystalline cellulose, 8mg magnesium stearate, and 25mg cross-linked polyvinylpyrrolidone are fully mixed, and 15% polyvinylpyrrolidone solution prepared in 50% ethanol solution is used as a binder to make a soft material. Experience "Hold it into a ball, pinch it and break it";

[0080] Granulation: sieve the soft materials to make wet granules;

[0081] Dry the wet granules, set the drying temperature to 45°C, gradually raise the temperature to 60°C, and dry until the moisture content of the granules is 3%;

[0082] Grain sizing: the dried granules are sieved to obtain granules with suitable particle size;

[0083] Tablet compression: After granulation, add 2-4% magnesium stearate to the granules by external addition method, mix evenly, adjust the pressure of the tablet machine, fill the granules into the tablet mold for tablet compression;

[0084] Inspection: Check the tablet appearance, tablet weight difference, h...

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Abstract

The invention discloses a preparation method of modified starch and an application, and relates to the technical field of starch preparation. The method comprises the steps as follows: beta-amylase ismodified, branching enzyme is added for continuous modification after enzyme inactivation, pullulanase is added for continuous modification after enzyme inactivation, an enzymolysis liquid is subjected to ethanol precipitation after enzyme deactivation, a precipitate is dried, and the modified starch is obtained. Starch is modified remarkably, the number of DP6-11 linear chains in the starch chain is greatly increased, and thus, the content of resistant starch in the modified starch can be significantly increased, and the starch can be conveniently applied to food and medicines.

Description

technical field [0001] The invention discloses a preparation method and application of modified starch, and relates to the technical field of starch preparation. Background technique [0002] In recent years, the incidence of diabetes and various complications has increased dramatically. The current method of controlling hyperglycemia is to inhibit the activity of α-glucosidase, and α-glucosidase inhibitors have been used to regulate postprandial hyperglycemia to achieve therapeutic purposes. However, it is reported that α-glucosidase chemical drug inhibitors can easily cause gastrointestinal diseases in patients with diabetes, such as abdominal pain, gastrointestinal and diarrhea, etc., so chemical drug inhibitors are not conducive to long-term use of diabetic patients, especially gastrointestinal dysfunction Good diabetic use, while chemical drug inhibitors also have potential other risks. [0003] Resistant starch (RS), also known as enzyme-resistant starch and indigest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12P19/22C12P19/16C12P19/04A23L33/125A61K31/718A61K31/352A61P3/10
CPCC12P19/22C12P19/16C12P19/04A23L33/125A61K31/718A61K31/352A61P3/10A23V2002/00A23V2200/328A23V2250/5118A61K2300/00C12Y302/01041C12Y302/01002A61K9/2013A61K9/2059A61K9/2054A61K9/2027C12Y204/01018A61K9/0056A61K36/87
Inventor 郭丽李慧李家豪桂一凡崔波
Owner QILU UNIV OF TECH
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