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Preparation method of flos lonicerae volatile oil soft capsule and vaporization inhalation type therapy method of soft capsule

A honeysuckle and inhalation technology, applied in the field of preparation of honeysuckle volatile oil soft capsules, can solve problems such as failure to function, gastrointestinal tract irritation, antibiotic resistance, etc., to avoid liver first-pass effect, reduce irritation, and reduce irritation Effect

Inactive Publication Date: 2020-07-03
YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are the following deficiencies in the treatment of acute tonsillitis: first, a large number of antibiotics are used to produce drug resistance; second, the oral or injection of drugs can stimulate the gastrointestinal tract and liver damage; Therapeutic volatile components are lost and fail to exert their effects

Method used

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  • Preparation method of flos lonicerae volatile oil soft capsule and vaporization inhalation type therapy method of soft capsule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] 1. Extraction of Honeysuckle Essential Oil

[0030] A method for preparing honeysuckle volatile oil soft capsules and its vaporization inhalation therapy. The honeysuckle volatile oil is extracted by steam distillation, and the steps are as follows: Weigh 300g of dried honeysuckle flower buds, cut them into pieces and place them in a round-bottomed flask Add 3000ml of distilled water, soak at room temperature for 12 hours, then sonicate for 30 minutes, and heat and distill for 5 hours. When there are no more oil droplets on the condenser tube, it means that the distillation is complete. Put the obtained product into a separatory funnel, add an appropriate amount of petroleum ether, shake well and extract. After standing still, take the upper layer, absorb excess water with anhydrous sodium sulfate, transfer to a distillation flask, and evaporate in a vacuum rotary at 45°C. After the petroleum ether evaporates completely, honeysuckle volatile oil is obtained, weighed, an...

Embodiment 2

[0038] Example 2 In vitro bacteriostasis of honeysuckle volatile oil

[0039] 1. Materials

[0040] Bacteria tested: Streptococcus pneumoniae, Bacillus subtilis, Escherichia coli, Staphylococcus aureus.

[0041] 2. Method

[0042] The inhibitory effect of the honeysuckle volatile oil extracted in Example 1 on the growth of the tested bacteria was measured by the cup and saucer method and the double-layer plate method. Invert the bottom plate first, then absorb 10 mL of the prepared bacterial solution, and mix it into 90 mL of culture medium cooled to about 45°C, so that the final concentration of the bacterial solution is 10 6 ~10 7 cfu / mL to prepare the upper plate with bacteria. After solidification, place sterile Oxford cups symmetrically on the plate, add 100 μL honeysuckle volatile oil to the Oxford cups, and carry out three parallel experiments, using sterile water as the blank control. Incubate at 37°C for 24-36 hours, measure the size of the inhibition zone by the...

Embodiment 3

[0048] Example 3 Anti-inflammatory effect of honeysuckle volatile oil

[0049] 1. Experimental grouping

[0050] Blank control group: 0.5% Tween-80 saline, orally administered at a dose of 20ml / kg.

[0051] Administration group: take the honeysuckle volatile oil extracted in Example 1, and administer it by intragastric administration at a low dose of 0.1 ml / kg and a high dose of 3 ml / kg.

[0052] Positive control group: dexamethasone, administered orally at a dose of 5 mg / kg.

[0053] 2. Method

[0054] Take 40 mice weighing 22.0±1.0 g, half male and half male, 10 mice in each group. On the basis of normal feeding, the blank control group was given intragastric administration of 0.5% Tween-80 normal saline (20ml / kg), and the treatment group was given intragastric administration once a day (low dose 0.1ml / kg, high dose 3ml / kg) , the positive control group was administered dexamethasone (5 mg / kg) for 5 consecutive days. One hour after the last administration, each mouse in ...

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Abstract

The invention discloses a preparation method of a flos lonicerae volatile oil soft capsule and a vaporization inhalation type therapy method of the soft capsule. Flos lonicerae is one of commonly usedand valuable Chinese medicinal materials determined by the State Council and is always very popular. The flos lonicerae medical material volatile oil has the functions of clearing heat and removing toxicity, diminishing inflammation, and resisting bacteria and viruses; and in order to improve the stability of the flos lonicerae volatile oil, a soft capsule dosage form of the flos lonicerae volatile oil is prepared. According to the vaporization inhalation type therapy method provided by the invention, an electronic heater is used as a drug delivery tool, the mechanical structure of the heateris used to destroy the flos lonicerae volatile oil soft capsule to slowly release the volatile oil contained in the soft capsule, the volatile oil is vaporized by means of electric heating and is inhaled into a respiratory tract through a mouth and nose, and pharmacodynamic molecules can directly reach a lesion site and quickly play a role. As a directional drug delivery route for respiratory diseases, the therapy method has an obvious quick-acting effect and localization effect, uses a local application manner, has a fast medicine effect and a small dose, and has an obvious curative effect on treatment of acute tonsillitis.

Description

technical field [0001] The invention belongs to the field of natural medicines, and in particular relates to a preparation method of honeysuckle volatile oil soft capsules and vaporization inhalation therapy thereof. Background technique [0002] Acute tonsillitis is a non-specific acute inflammation of the palatine tonsils, often accompanied by a certain degree of acute inflammation of the pharyngeal mucosa and pharyngeal lymphoid tissue, and often occurs in children and adolescents. The main clinical manifestations are: enlarged tonsils, obvious sore throat, especially when swallowing, diffuse hyperemia of the pharyngeal mucosa, aversion to cold, high fever and other symptoms. [0003] Modern medicine believes that the most common pathogenic bacteria causing acute tonsillitis is beta-hemolytic streptococcus, followed by Staphylococcus aureus, Streptococcus pneumoniae and Haemophilus influenzae. Tonsillitis is also associated with viral infections such as adenovirus and Co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/355A61K9/48A61K47/44A61K47/42A61P11/04
CPCA61K9/007A61K9/4808A61K9/4825A61K9/4858A61K36/355A61K2236/331A61P11/04
Inventor 刘胜贵王钲霖薛红芬付彬彬李智高孔令羽蒋永昌马海悦
Owner YUNNAN LVXIN BIOLOGICAL PHARMA CO LTD
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