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Preparation and application of hydroxyethyl cellulose-sodium alginate hydrogel

A technology of hydroxyethyl cellulose and sodium alginate, which is applied in the field of medicine, can solve the problems of short effective concentration maintenance time and inability to meet clinical treatment, and achieve the effects of improving the effect and time, low biological toxicity, and reducing blood in the stool

Inactive Publication Date: 2020-07-03
广州古泉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Usually traditional dosage forms, such as injections, tablets, capsules, etc., have been unable to meet the needs of clinical treatment due to the short duration of effective concentration.

Method used

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  • Preparation and application of hydroxyethyl cellulose-sodium alginate hydrogel
  • Preparation and application of hydroxyethyl cellulose-sodium alginate hydrogel
  • Preparation and application of hydroxyethyl cellulose-sodium alginate hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The synthetic method of hydroxyethyl cellulose-sodium alginate hydrogel:

[0040] (1) Formula (III) (8.41g, 40mmol), formula (II) (1.93g, 5mmol) and 4-dimethylaminopyridine (0.0386g, 0.316mmol) were weighed and dissolved in 20mL of anhydrous tetrahydrofuran. Then, dicyclohexylcarbodiimide (3.09 g, 15 mmol) was added into anhydrous tetrahydrofuran (5 mL), and dropped into an ice bath. The resulting mixture was stirred at 30 °C for 10 h, the reactant was filtered, the solvent was removed by rotary evaporation, and the product was purified by recrystallization from ethyl acetate to obtain the product formula (IV);

[0041] (2) Weigh 2 g of formula (Ⅳ) (3.5 mmol) and 1.32 g of EDC (6.9 mmol) and dissolve them in 20 mL of absolute ethanol, and stir for 50 minutes to activate the carboxyl group; formula (Ⅴ) (3.0 mmol) and 0.8 g of NHS (6.9 mmol) was dissolved in 20 mL of deionized water to activate the hydroxyl group, and the activated formula (Ⅴ) (3.0 mmol) was slowly added...

Embodiment 2

[0043] Preparation of Nedaplatin-loaded Hydroxyethyl Cellulose-Sodium Alginate Hydrogel

[0044]Nedaplatin was encapsulated into the crosslinked network of hydroxyethylcellulose-sodium alginate hydrogel. 50mg hydroxyethylcellulose-sodium alginate hydrogel hydrogel, 10mg nedaplatin dissolved in the system of dimethyl sulfoxide / water with a volume ratio of 1:9, after desalting at room temperature for 24 hours, the It was slowly added dropwise to a large amount of ultrapure water (500 mL), followed by rapid stirring at room temperature for 1 hour. The solution was dialyzed against ultrapure water and filtered through a 0.45 μm needle filter to obtain nedaplatin-loaded hydrogel.

Embodiment 3

[0046] Drug loading capacity (DLC) and drug loading efficiency (DLE) of nedaplatin-loaded hydroxyethylcellulose-sodium alginate hydrogel

[0047] Morphology: A drop of hydrogel solution was evenly dropped on a copper grid with a carbon film, and then after it was dried at room temperature, a TEM was used to capture the morphology of the micelles. Particle size: The average size and size distribution of the micelles were determined by DLS. figure 1 The topography pictures of hydroxyethyl cellulose-sodium alginate hydrogels loaded with nedaplatin were captured by TEM, figure 2 Size distribution profile of nedaplatin-loaded hydroxyethylcellulose-sodium alginate hydrogel determined by DLS.

[0048] Drug Loading Capacity (DLC) and Drug Loading Efficiency (DLE): The nedaplatin-loaded hydroxyethylcellulose-sodium alginate hydrogel was frozen to obtain a light yellow solid powder, and the powder was dissolved in methanol, and the preparation was repeated for 4 Hydroxyethylcellulose...

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Abstract

The invention provides preparation and application of hydroxyethyl cellulose-sodium alginate hydrogel. The provided hydroxyethyl cellulose-sodium alginate hydrogel is used as a medicine carrying carrier and has the characteristics of simple synthesis method and high encapsulation efficiency. The carrier hydrogel has a group having high affinity for a living body, has low biological toxicity, and is an oral hydrogel carrier. Drugs in the carrier hydrogel is prevented from being released under a acidic condition in the stomach, so that the drugs can target intestinal tumors, the treatment effectof the drugs can be slowly released, the repair function of intestinal mucosa and the like can be promoted, the side effects such as hematochezia caused by the intestinal tumors can be effectively reduced, and the hydrogel serving as a new drug carrier hydrogel has wide substantive application.

Description

technical field [0001] The invention relates to the preparation and application of a hydroxyethyl cellulose-sodium alginate hydrogel, which belongs to the field of medicine. Background technique [0002] Drug delivery systems refer to pharmaceutical preparations that improve the therapeutic effect of drugs through different administration forms. Usually traditional dosage forms, such as injections, tablets, capsules, etc., have been unable to meet the needs of clinical treatment due to the shortcoming of their effective concentration maintenance time. In order to overcome this defect, new drug delivery systems such as hydrogel drug loading have attracted widespread attention of researchers. The molecular weight of the product after degradation of the hydrogel polymer carrier is lower than the excretion limit of the kidney (<30kDa), and the safety is improved. Among them, sodium alginate is particularly noteworthy in its bio-affinity and bio-absorbability. When it is impl...

Claims

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Application Information

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IPC IPC(8): C08J3/075C08L5/04C08L1/28C08K5/372C08G81/00A61K9/06A61K45/00A61K47/36A61K47/38A61P35/00A61P35/02
CPCA61K9/06A61K45/00A61K47/36A61K47/38A61P35/00A61P35/02C08G81/00C08J3/075C08J2305/04C08J2401/28C08K5/372
Inventor 祝发顺
Owner 广州古泉生物科技有限公司
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