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Gel for infantile hemangioma and preparation method of gel

A technology for infant hemangioma and gel, which is applied in the directions of medical preparations with non-active ingredients, medical preparations containing active ingredients, and anti-tumor drugs, which can solve the problems of less research on infant hemangioma.

Active Publication Date: 2020-07-07
ZHENGZHOU CHILDRENS HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are few studies on the effective combination of the two to prepare a drug gel for the treatment of infantile hemangioma

Method used

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  • Gel for infantile hemangioma and preparation method of gel
  • Gel for infantile hemangioma and preparation method of gel
  • Gel for infantile hemangioma and preparation method of gel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of amphiphilic polymer NVP-maleic acid Guerbet alcohol monoester copolymer is carried out according to the following steps:

[0022] (1) Mix 15g of maleic anhydride and 60mL of 2-octyl-dodecane Guerbet alcohol, stir magnetically at 70°C, and freeze the product at 0°C after 6 hours of reaction. After solidification, use methanol and water according to Mixed solution 250mL with a volume ratio of 2:8, wash the reactant, remove excess unreacted maleic anhydride, dry to obtain Guerbet dodecyl monoester maleate;

[0023] (2) Take 0.2g of initiator lauroyl peroxide, 8g of N-vinylpyrrolidone and 2g of Guerbet dodecyl maleate monoester obtained in step (1), add 170mL of n-heptane, and protect it under 80 ℃, mechanical stirring, the white precipitate;

[0024] (3) Wash the white precipitate obtained in step (2) with 250 mL of n-heptane at 70°C for 4 times, filter it with suction, and dry it at room temperature for 36 hours to obtain the amphiphilic polymer NVP-Gu...

Embodiment 2

[0026] A preparation method for infantile hemangioma gel, according to the following steps:

[0027] (1) 5g of timolol maleate and 5g of propranolol were dissolved in 300mL of purified water to obtain a mixed solution;

[0028] (2) Add 0.1 g of NVP-Maleic acid Guerbet alcohol monoester copolymer obtained in Example 1, 10 g of sodium lauryl sulfate and 20 g of glycerin into 200 mL of purified water, heat to 85°C and stir for 2 hours , then cooled to room temperature, adding preservative ethylparaben 1g, to obtain a mixed solution;

[0029] (3) At 85°C, heat 20g of vaseline, 30g of liquid paraffin, and 10g of glyceryl monostearate until molten, and stir evenly to obtain an oil phase;

[0030] (4) Mix the mixed solution obtained in step (1) and step (2) together and stir well, slowly add the oil phase obtained in step (3) under constant stirring, then continue stirring until uniform, cool to room temperature to obtain a gel for infantile hemangioma.

[0031] Implementation col...

Embodiment 5

[0044] A preparation method for infantile hemangioma gel, according to the following steps:

[0045] (1) 5g of timolol maleate and 5g of propranolol were dissolved in 300mL of purified water to obtain a mixed solution;

[0046] (2) Add 10 g of sodium lauryl sulfate and 20 g of glycerin to 200 mL of purified water, heat to 85°C and stir for 2 hours, then cool to room temperature, add 1 g of preservative ethylparaben to obtain a mixed solution;

[0047] (3) At 85°C, heat 20g of vaseline, 30g of liquid paraffin, and 10g of glyceryl monostearate until molten, and stir evenly to obtain an oil phase;

[0048] (4) Mix the mixed solution obtained in step (1) and step (2) together and stir well, slowly add the oil phase obtained in step (3) under constant stirring, then continue stirring until uniform, cool to room temperature to obtain drug gel.

[0049] Implementation column 6

[0050] A preparation method for infantile hemangioma gel, according to the following steps:

[0051] (...

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Abstract

The invention provides gel for infantile hemangioma and a preparation method of the gel, and belongs to the technical field of pharmaceutical preparations. The gel for infantile hemangioma consists ofpropranolol, timolol maleate, NVP-Gelbert alcohol maleate monoester copolymer, vaseline, liquid paraffin, glycerin monostearate, lauryl sodium sulfate, glycerinum, ethylparaben and water. The gel forhemangioma has the advantages of being easy to prepare, convenient to use, capable of taking effect fast, long in acting time, remarkable in treatment effect and the like, the acting time of the drugis prolonged through the NVP-Guerbet alcohol maleate monoester copolymer, the biocompatibility of the drug is improved, and the advantage of controlled release is achieved. The gel for hemangioma issuitable for industrial large-scale production and used for treating infantile hemangioma.

Description

technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a gel for infantile hemangioma and a preparation method thereof. Background technique [0002] Infantile Henangiomas (IH) are the most common benign hemangiomas in childhood, with an incidence of about 4% to 5%. The incidence of infants under 1 year old is about 10%, and about 60% of them occur in the head and neck. , can also occur in the trunk, limbs, etc. Its typical clinical manifestations are rapid proliferation within 1 year of age and slow regression thereafter. Although the hemangioma can regress on its own, about 10% of the children still suffer from serious complications such as ulcers, infection, pain, and even blindness and suffocation. Because the hemangioma mostly occurs on the head and face, it becomes a serious psychological burden for the parents of the children. Currently available treatments include surgical resection, cryotherapy, radiati...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K47/34A61K31/138A61K31/5377A61P35/00
CPCA61K9/06A61K47/34A61K31/138A61K31/5377A61P35/00A61K2300/00Y02A50/30
Inventor 牛振喜狄奇胡靖刘景陈志平
Owner ZHENGZHOU CHILDRENS HOSPITAL
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