Application of penthorum chinense pursh in preparation of medicines for treating hyperproteinuria

An extract of C. chinensis and the technology of C. sativa, which are applied in the application field of C. chinensis in the preparation of drugs for the treatment of high proteinuria, can solve problems such as no treatment means, achieve broad application prospects, excellent therapeutic effect, and fast recovery Effect

Active Publication Date: 2020-07-14
北京致远伟业生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Glomerulosclerosis and tubulointerstitial fibrosis (renal fibrosis) are the pathological basis of chronic renal failure, and are also the common pathway for almost all renal diseases to progress to end-stage renal failure. However, there is currently no effective treatment. To slow down and treat the development of kidney disease, it is especially important to reduce proteinuria

Method used

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  • Application of penthorum chinense pursh in preparation of medicines for treating hyperproteinuria
  • Application of penthorum chinense pursh in preparation of medicines for treating hyperproteinuria
  • Application of penthorum chinense pursh in preparation of medicines for treating hyperproteinuria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Example 1 Drug efficacy experiment of Ganhuangcao extract in treating hyperalbuminuria

[0037] The doxorubicin nephropathy animal model is a widely used classical experimental nephropathy animal model, which has the characteristics of simplicity, high success rate, long and stable massive proteinuria, and stable lesions. The evolution process of kidney tissue damage in rats with doxorubicin nephropathy is similar to the chronic pathological process of human kidney disease and kidney damage, so doxorubicin-induced nephropathy can be used as a model of experimental nephropathy. This model has the characteristics of a large amount of proteinuria, and it is a commonly used clinical experimental kidney disease model to evaluate the degree of various kidney damage and the effect of drug treatment on hyperproteinuria. The present invention uses adriamycin-induced nephropathy as a model of experimental nephropathy. The main symptoms of the disease are: massive proteinuria, hy...

Embodiment 2

[0089] Example 2 Effects of Huangcao on urinary protein in rats with membranous nephropathy

[0090] 1. Materials and methods

[0091] (1) Material

[0092] The preparation of Huangcao extract is the same as in Example 1.

[0093] Animal experiments and ethics statement: Male Wistar and Sprague-Dawley rats and male New Zealand white rabbits were obtained from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences. All rats were housed under specific pathogen-free conditions and rabbits were housed in a clean-grade animal laboratory. All animal procedures were performed in accordance with the Animal Care and Use Protocol (2013-01-ZJP-19) approved by the Institutional Animal Care and Use Committee (IACUC) of Dongzhimen Hospital.

[0094] (2) Experimental model making

[0095]Fx1A antigen was prepared from the renal cortex of male Wistar rats, and then male New Zealand white rabbits were immunized with Fx1A antigen to prepare rabbit antiserum (see "Chen Zh...

Embodiment 3

[0105] Example 3 The effect of chamomile grass on the renal function of rats with diabetic nephropathy

[0106] 1. Materials and methods

[0107] (1) Material

[0108] The preparation of C. chinensis preparation is the same as in Example 1, and the source of Sprague-Dawley rats is the same as in Example 2.

[0109] (2) Experimental model making

[0110] After adaptive feeding of rats for 1 week, 5 rats were randomly selected as normal group, and the rest were model group. Urinary protein was determined, and after negative results, pentobarbital sodium was injected intraperitoneally for anesthesia, routine skin preparation and disinfection, left nephrectomy was performed through the back incision, and gentamicin was dripped at the wound to prevent infection. Two weeks later, the model group was given a single injection of 1% streptozotocin solution (prepared on ice with 0.1mol / L lemon buffer, pH 4.2-4.5) 55 mg / kg into the left lower abdominal cavity, and the blank group was ...

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Abstract

The invention discloses application of penthorum chinense pursh in preparation of medicines for treating hyperproteinuria. Based on the inventor, the penthorum chinense pursh has good curative effectson a large amount of proteinuria, hypoproteinemia, lipid metabolism disorder and different degrees of edema caused by hyperproteinuria. The penthorum chinense pursh has the effect of protecting the liver, so that the penthorum chinense pursh is higher in safety in preparation of medicines for treating hyperproteinuria.

Description

technical field [0001] The invention relates to the application of a kind of Miao medicine, in particular to the application of C. chinensis in the preparation of medicine for treating hyperalbuminuria. Background technique [0002] Catch yellow grass, also known as root vegetable, water willow and water euphemum, is the dry aerial part of the perennial herbaceous plant Penthorum chinense Pursh (Penthorum chinense Pursh). Chamomile grass was first recorded in "Rescue Famine Materia Medica" in the Ming Dynasty. It has the effects of clearing away heat and detoxification, reducing yellowness and dampness, promoting blood circulation and dispelling blood stasis, diuresis and swelling. It is an empirical prescription for the prevention and treatment of liver diseases of the Miao people. It is mainly distributed in the humid area at an altitude of about 1000m in the Wumeng Mountains. It is an authentic medicinal material in Gulin County, Sichuan Province. The chemical constituen...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P13/12A61P13/00
CPCA61K36/185A61P13/12A61P13/00A61K2236/331A61K2236/39A61K2236/53
Inventor 刘玉宁聂红刘伟敬汤丹贾奇柴晓猛
Owner 北京致远伟业生物科技有限公司
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