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Preparation method of degradable membrane rich in stem cells for wound repair

A wound repair and stem cell technology, applied in medical science, prosthesis, etc., can solve the problems of insufficient fibrin membrane strength, limited wide use, high price, etc., achieves good degradability and biocompatibility, and simple and easy preparation method. The effect of high performance and mechanical strength

Inactive Publication Date: 2020-07-17
CHENGDU ZHIA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, fibrin membranes are not strong enough, degrade too quickly, and are expensive, limiting their widespread use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A method for preparing a degradable film rich in stem cells for wound repair, comprising the steps of:

[0030] Step S1, preparation of aloin D / D-allylglycine / limonene-1 2-epoxide copolymer: aloin D, D-allylglycine, limonene-1 2-epoxide, Azobisisobutyronitrile was added to dimethyl sulfoxide, stirred and reacted under nitrogen atmosphere at 70°C for 3 hours, then dimethyl sulfoxide was removed by rotary evaporation, the product was dissolved in water, insoluble matter was removed by filtration, and water was removed by rotary evaporation again. Place in a vacuum drying oven at 80°C and dry to constant weight to obtain aloin D / D-allylglycine / limonene-1 2-epoxide copolymer; the aloin D, D-allylglycine, The mass ratio of limonene-1 2-epoxide, azobisisobutyronitrile and dimethylsulfoxide is 2:1:0.2:0.03:10;

[0031]Step S2, preparation of degradable membrane material: aloin D / D-allylglycine / limonene-1 2-epoxide copolymer, sodium sulfobutylbeta cyclodextrin, Chitosan quate...

Embodiment 2

[0035] A method for preparing a degradable film rich in stem cells for wound repair, comprising the steps of:

[0036] Step S1, preparation of aloin D / D-allylglycine / limonene-1 2-epoxide copolymer: aloin D, D-allylglycine, limonene-1 2-epoxide, Azobisisoheptanonitrile was added to N,N-dimethylformamide, stirred and reacted for 3.5 hours under a helium atmosphere at 72°C, and N,N-dimethylformamide was removed by rotary evaporation, and the product was dissolved in water and filtered Remove the insoluble matter, then remove the water by rotary evaporation, and then place it in a vacuum drying oven at 80-90°C to dry to constant weight to obtain the aloin D / D-allylglycine / limonene-1 2-epoxide copolymer; The mass ratio of aloin D, D-allylglycine, limonene-12-epoxide, azobisisoheptanonitrile, N, N-dimethylformamide is 2:1:0.23:0.035: 12;

[0037] Step S2, preparation of degradable membrane material: aloin D / D-allylglycine / limonene-1 2-epoxide copolymer, sodium sulfobutylbeta cyclo...

Embodiment 3

[0041] A method for preparing a degradable film rich in stem cells for wound repair, comprising the steps of:

[0042] Step S1, preparation of aloin D / D-allylglycine / limonene-1 2-epoxide copolymer: aloin D, D-allylglycine, limonene-1 2-epoxide, Azobisisobutyronitrile was added to N,N-dimethylacetamide, stirred and reacted at 75°C for 4 hours in a neon atmosphere, then rotary evaporated to remove N,N-dimethylacetamide, dissolved in water, and filtered Remove the insoluble matter, then remove the water by rotary evaporation, and then place it in a vacuum drying oven at 85°C to dry to constant weight to obtain the aloin D / D-allylglycine / limonene-1 2-epoxide copolymer; the aloe The mass ratio of neoglycoside D, D-allylglycine, limonene-1 2-epoxide, azobisisobutyronitrile, and N,N-dimethylacetamide is 2:1:0.25:0.04:13;

[0043] Step S2, preparation of degradable membrane material: aloin D / D-allylglycine / limonene-1 2-epoxide copolymer, sodium sulfobutylbeta cyclodextrin, Chitosan ...

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PUM

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Abstract

The invention discloses a preparation method of a degradable membrane rich in stem cells for wound repair. The preparation method is characterized by comprising the following steps: S1, preparing an aloeresin D / D-allyl glycine / limonene-1,2-epoxide copolymer; S2, preparing a degradable membrane material; and S3, performing radiation crosslinking. The invention also provides the degradable membranerich in stem cells for wound repair, wherein the degradable membrane is prepared according to the preparation method of the degradable membrane rich in stem cells for wound repair. The degradable membrane rich in stem cells for wound repair has the advantages of good wound repair effect, good degradability and biocompatibility, high mechanical strength and excellent anti-infection and anti-inflammatory performance.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a method for preparing a degradable membrane rich in stem cells for wound repair. Background technique [0002] Skin is an important tissue organ that covers and protects the body surface. Skin defects and abnormalities are often caused by inflammation, ulcers, trauma, burns, postoperative tumors, and congenital deformities. Clinically, skin damage can easily lead to tissue inflammation and ulcers, and severe cases can lead to amputation and life-threatening. Therefore, it is necessary to use biofilm materials for wound skin care, so as to promote wound repair, prevent wound infection, and cause other complications. [0003] For exposed skin wounds, gauze is traditionally used the most. Gauze is mostly processed from cotton, burlap and linen, and is an inert material that does not directly promote wound healing. With the in-depth research on wound healing, it is r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/60A61L27/50A61L27/38A61L27/54A61L27/16A61L27/20
CPCA61L27/16A61L27/20A61L27/3834A61L27/50A61L27/54A61L27/60A61L2300/214A61L2300/404A61L2300/41A61L2300/412A61L2300/45C08L47/00C08L5/16C08L5/02C08L5/08
Inventor 向兴力
Owner CHENGDU ZHIA TECH CO LTD
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