A kind of water-in-oil type whitening skin care lotion and preparation method thereof
A water-in-oil, skin care lotion technology, applied in skin care preparations, pharmaceutical formulations, cosmetic preparations, etc., can solve problems such as reducing ultraviolet intensity and poor whitening effect, and achieve sterilization and anti-inflammatory, reduce burden, and inhibit bacteria. breeding effect
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Embodiment 1
[0024] The concrete preparation process of antioxidant whitening agent is as follows:
[0025] Step 1: Weigh 11g of resorcinol and add it to 200mL ethanol solution, stir and dissolve, adjust the pH of the reaction solution to 1 with hydrochloric acid, then add 2.3g of paraformaldehyde into the reaction vessel, stir and dissolve, then heat up to 70-80°C, Then add 25g of sulfadiazine to the reaction vessel, stir and dissolve, then react at a constant temperature for 4-5h, then cool down to room temperature, dropwise add a sodium hydroxide solution with a mass concentration of 1% to the product until precipitation occurs and stop adding , and then filter, wash and dry to obtain product A, and the reaction structure is as follows;
[0026]
[0027]Step 2: Add 10g of the product A prepared in step 1 into the reaction vessel, then add 4.3g of p-hydroxyphenylacetic acid, 21.6g of aluminum chloride and 150mL of ethyl acetate, heat up to 70-75°C and stir until the solid dissolves, ...
Embodiment 2
[0032] The specific preparation process of the antioxidant whitening agent is as follows: Weigh 11g of resorcinol and add it to 200mL of ethanol solution and stir to dissolve, adjust the pH of the reaction solution to 1 with hydrochloric acid, then add 4.5g of paraformaldehyde to the reaction vessel, stir to dissolve and then heat up to 70-80° C., then add 55 g of sulfadiazine to the reaction vessel, stir and dissolve, then react at a constant temperature for 4-5 hours, then cool down to room temperature, and dropwise add a sodium hydroxide solution with a mass concentration of 1% to the product until If there is precipitation, stop the dropwise addition, and then filter, wash and dry to obtain product A, which is an antioxidant whitening agent. The reaction structure is as follows;
[0033]
Embodiment 3
[0035] The concrete preparation process of antioxidant whitening agent is as follows:
[0036] Step 1: Add 10g of resorcinol to the reaction vessel, then add 8.6g of p-hydroxyphenylacetic acid, 41.6g of aluminum chloride and 250mL of ethyl acetate to it, heat up to 70-75°C and stir until the solid dissolves, then react at constant temperature 2-2.5h, then the solvent is recovered by distillation under reduced pressure, then a certain amount of hydrochloric acid solution with a mass concentration of 8% will be added to the reaction vessel, and after stirring and reacting for 30-40min, filter, wash and dry to obtain product A. The reaction structure is as follows Show;
[0037]
[0038] Step 2: 10g of the product A prepared in step 1 and 95mL N, N-dimethylformamide were added to the reaction vessel at the same time, then 42g of hexahydropyridine was added thereto, stirred and dissolved, and 21g of trihydropyridine was added dropwise to the reaction vessel. Phosphorus chlorid...
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