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Preparation method and application of ion co-doped hydroxyapatite transparent ceramics

A technology of hydroxyapatite and transparent ceramics, applied in the field of medical devices, can solve the problems of long reaction time, inability to carry out mass production, and few types of doping ions, etc.

Active Publication Date: 2020-10-23
SUZHOU DINGAN ELECTRONICS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, ion-doped hydroxyapatite powder is mostly prepared by hydrothermal synthesis method, which requires high equipment, difficult investment and operation, long reaction time, and cannot be mass-produced in batches
The types of doping ions in the existing multi-ion doped hydroxyapatite powder are relatively small, and the ceramics sintered with hydroxyapatite with fewer doping ions have high crystallinity, and the crystallinity cannot be controlled, and transparent ions cannot be obtained. doped hydroxyapatite ceramics

Method used

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  • Preparation method and application of ion co-doped hydroxyapatite transparent ceramics
  • Preparation method and application of ion co-doped hydroxyapatite transparent ceramics
  • Preparation method and application of ion co-doped hydroxyapatite transparent ceramics

Examples

Experimental program
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Effect test

Embodiment 1

[0037] [Ca 10 (PO 4 ) 6 (OH) 2 ]Transparent ceramic microspheres

[0038] Weigh 826.53g of calcium nitrate in a reaction kettle, add 10L of deionized water to prepare a calcium nitrate solution, and adjust the pH value of the calcium nitrate solution to 13; weigh 277.33g of diammonium hydrogen phosphate in a container, add 2L of deionized water to prepare a Diammonium hydrogen phosphate solution; add the diammonium hydrogen phosphate solution to the reaction kettle at a speed of 5ml / min for reaction, and react in a water bath at 30°C for 24 hours. After the reaction, the reactant slurry is obtained; remove excess liquid in the reactant slurry by suction filtration , control the solid content of the reactant slurry to 40% to obtain the precursor slurry; carry out the spray granulation process of the precursor slurry (process conditions: feeding speed 10ml / min, inlet air temperature 180~200°C, outlet air temperature 110~120°C, the speed of the nozzle is 250rpm) to obtain th...

Embodiment 2

[0044] [Ca 8 K 2 ](PO 4 ) 6 [(OH)F] transparent ceramics

[0045] Weigh 619.89g of calcium nitrate, 70.77g of potassium nitrate, and 13.664g of calcium fluoride in a reaction kettle, add 8L of deionized water to make a mixed solution, adjust the pH of the mixed solution to 12; weigh 277.33g of diammonium hydrogen phosphate in a container , add 2L of deionized water to prepare a diammonium hydrogen phosphate solution; add the diammonium hydrogen phosphate solution to the mixed solution in the reaction kettle at a rate of 8ml / min for reaction, and react in a water bath at 40°C for 18h. After the reaction is completed, a reaction slurry is obtained Remove excess liquid in the reaction slurry by suction filtration, control the solid content of the reaction slurry to be 85%, and obtain the precursor slurry; the precursor slurry is made into a cylindrical green body (diameter 0.5 ~ 1.5mm, length 1~3mm), the cylindrical ceramic green body was subjected to microwave sintering (sin...

Embodiment 3

[0052] [Ca 8 KNa](PO 4 ) 6 [(OH)F] transparent ceramics

[0053]Weigh 619.89g of calcium nitrate, 35.77g of potassium nitrate, 36.37g of sodium nitrate, and 13.664g of calcium fluoride in a reaction kettle, add 8L of deionized water to form a mixed solution, adjust the pH value of the mixed solution to 12; weigh 277.33g of hydrogen phosphate Put diammonium in the container, add 2L deionized water to make diammonium hydrogen phosphate solution; add the diammonium hydrogen phosphate solution into the mixed solution in the reaction kettle at a speed of 10ml / min for reaction, react in a water bath at 40°C for 18h, after the reaction The reaction slurry is obtained; the excess liquid in the reaction slurry is removed by suction filtration, and the solid content of the reaction slurry is controlled to be 85% to obtain the precursor slurry; the precursor slurry is made into a cylindrical green body (diameter 0.5~1.0 mm, length 1~2mm), the cylindrical green body was sintered by inf...

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Abstract

The invention relates to a preparation method and application of ion-co-doped hydroxyapatite transparent ceramics. The general formula of ion-co-doped hydroxyapatite transparent ceramics is [Ca 10‑x m x ][(PO 4 ) 6‑y (SiO 4 ) y ][(OH) 2‑z N z ], M is selected from one or more of K ions, Na ions, Mg ions, Al ions, Zn ions, Sr ions, Mn ions, Co ions, Ag ions, Cu ions, Fe ions; N is F ions, Cl ion, CO 3 2‑ One or more of the ions; 0≤x<10, 0≤y<6, 0≤z<2; the preparation method disclosed in the present invention adopts the chemical precipitation method to obtain the precursor slurry, and controls its solid content, The ion-co-doped hydroxyapatite transparent ceramics can be obtained by molding, microwave or infrared sintering, which can be used in the field of repairing hard tissue defects such as teeth, jaws, spine and joints.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a preparation method and application of ion co-doped hydroxyapatite transparent ceramics. Background technique [0002] As the main inorganic component of natural bone tissue, hydroxyapatite (Hydroxyaptite) has excellent biocompatibility (Biocompatibility) and osteoconductivity (Osteoconduction), and can form chemical bonds with living bone tissue. Biological hard tissue filling, repairing and replacement materials have been widely used in clinical practice. However, pure hydroxyapatite still has defects in biodegradation and new bone growth, matching of elastic modulus and host bone modulus, as well as vascularization, osseointegration ability and ability to induce bone regeneration. Therefore, the clinical application of hydroxyapatite is restricted to a certain extent. Element-doped hydroxyapatite is to use functional elements to replace specific positions in the hyd...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/10A61L27/50A61L27/54C04B35/447C04B35/22C04B35/195C04B35/20C04B35/16
CPCA61L27/12A61L27/10A61L27/50A61L27/54C04B35/447C04B35/22C04B35/195C04B35/20C04B35/16A61L2430/12A61L2430/02A61L2430/24A61L2430/38A61L2300/104A61L2300/102A61L2300/404C04B2235/9653C04B2235/443C04B2235/442C04B2235/449C04B2235/3201C04B2235/3206C04B2235/444C04B2235/445C04B2235/3427C04B2235/483C04B2235/6562C04B2235/6567C04B2235/667C04B2235/785C04B2235/96C04B2235/95
Inventor 徐传艳朱阳光李亚东李亚军
Owner SUZHOU DINGAN ELECTRONICS TECH