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Preparation method of chitosan microsphere material

A technology of chitosan microspheres and chitosan, which is applied in the field of natural polymers and polymer materials, and can solve problems such as high equipment requirements and difficult industrial production

Active Publication Date: 2020-08-11
WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The freezing-thawing process consumes a lot of energy and requires high equipment, which is a major problem for industrial production
[0006] At present, there is no report on the preparation of chitosan microspheres by dissolving chitosan in a weakly alkaline aqueous solution.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] Shrimp shells are soaked in lye to remove protein, soaked in acid solution to remove inorganic salts, and decolorized with hydrogen peroxide solution to obtain purified chitin. Chitin at a concentration of 12.5mol·kg -1 Heating in sodium hydroxide aqueous solution for 1 h to carry out deacetylation reaction, to obtain chitosan with a degree of deacetylation of about 70%. The pre-prepared concentration is 0.2mol kg -1 Lithium bicarbonate—0.6mol·kg -1 Add 3 g of chitosan to 97 g of urea aqueous solution, stir at 10° C. for 3 h, and obtain a transparent chitosan solution after centrifugal defoaming. . Chitosan stock solution and oil phase of 2 times the volume ratio (containing 0.5% Span 80 in liquid paraffin), chitosan monomer and epoxy chlorohydrin with a molar ratio of epoxy group of 1:10 are mixed, and the rotating speed is 800rpm Microspheres formed after stirring for 1 h. The obtained microspheres are poured into 90 wt% ethanol aqueous solution for regeneration,...

Embodiment 2

[0053] Crab shells are soaked in lye to remove protein, soaked in acid solution to remove inorganic salts, and decolorized with hydrogen peroxide solution to obtain purified chitin. Chitin at a concentration of 8.0mol·kg -1 Heating in potassium hydroxide aqueous solution for 2 hours to carry out deacetylation reaction to obtain chitosan with a degree of deacetylation of about 60%. The pre-prepared concentration is 0.2mol kg -1 Sodium bicarbonate—0.6mol·kg -1 Add 3 g of chitosan to 97 g of urea aqueous solution, stir at 20° C. for 60 min, and obtain a transparent chitosan solution after centrifugal defoaming. The hydrophobic membrane with a pore size of 4.7 microns is soaked in the lipophilic substance, so that the porous membrane is fully wetted to ensure that the hydrophobic links on the membrane are completely stretched out. Add Span 85 into 1L of the mixed oil phase of liquid paraffin and petroleum ether, stir until completely dissolved as the oil phase (the volume ratio...

Embodiment 3

[0055] The squid bones are soaked in lye to remove protein, and soaked in acid to remove inorganic salts to obtain purified chitin. Chitin at a concentration of 10.0mol·kg -1 Heating in potassium hydroxide aqueous solution for 2 hours to carry out deacetylation reaction to obtain chitosan with a degree of deacetylation of about 60%. The pre-prepared concentration is 0.2mol kg -1 Potassium bicarbonate—0.6mol kg -1 Add 3 g of chitosan to 97 g of urea aqueous solution, stir at 30° C. for 180 min, and obtain a transparent chitosan solution after centrifugal degassing. The hydrophobic membrane with a pore size of 13 microns is soaked in the lipophilic substance, so that the porous membrane is fully wetted to ensure that the hydrophobic links on the membrane are completely stretched out. Add the oil-soluble emulsifier to 1L of the mixed oil phase of liquid paraffin and petroleum ether, stir until completely dissolved as the oil phase (the volume ratio of liquid paraffin and petro...

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PUM

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Abstract

The invention discloses a preparation method of a chitosan microsphere material. The preparation method comprises the following steps: firstly, adding chitosan into an aqueous solution of bicarbonate,and directly stirring to dissolve chitosan; or dissolving chitosan with dilute acid, neutralizing with alkali without separation, continuing to add bicarbonate, and stirring to dissolve chitosan; adding chitosan into an aqueous solution of alkali liquor or carbonate, and introducing carbon dioxide to generate bicarbonate to dissolve chitosan; carrying out deacetylation reaction on chitin to generate chitosan, adjusting the concentration of alkali liquor, and introducing carbon dioxide to generate bicarbonate to dissolve chitosan; and the addition of the stabilizer is beneficial to enhancing the dissolving capacity; taking a chitosan solution as a water phase, obtaining chitosan emulsion droplets by utilizing a membrane emulsifier, microfluidic equipment and a conventional stirring deviceunder the assistance of an oil phase, and curing the emulsion droplets to obtain the chitosan gel microspheres. According to the method, degradation of chitosan under acidic or strong alkaline conditions is avoided, and the stability of the chitosan solution in the processing process is guaranteed.

Description

technical field [0001] The invention belongs to the field of natural macromolecules and macromolecular materials, and in particular relates to a preparation method of chitosan microsphere materials. Background technique [0002] Chitosan is the product of deacetylation of chitin. When the N-deacetylation degree of chitin is above 55%, chitin is transformed into chitosan. The reserves of chitin and chitosan in nature are a class of natural polymers second only to cellulose. [0003] Chitosan microsphere material is a multifunctional polymer material with chitosan as the main raw material, which forms emulsion droplets after dissolution and emulsification, and forms microspheres after chemical crosslinking or physical crosslinking. Chitosan microsphere material not only has good biocompatibility and biodegradability, but also has antibacterial properties, can promote wound healing, has hemostatic effect, and has a wide range of applications in the fields of biomedicine and dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/16C08L5/08
CPCC08J3/16C08J2305/08
Inventor 蔡杰钟奕张俐娜
Owner WUHAN UNIV
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