Tetrahydroxy phthalocyanine zinc-reduced graphene oxide nano-composite as well as electrochemical sensor prepared from the same and application thereof

A nanocomposite, zinc hydroxyphthalocyanine technology, applied in the field of electrochemistry and nanomaterials, to achieve good conductivity, good reproducibility, and improved dispersion

Active Publication Date: 2020-08-11
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the construction of a new type of electrochemical sensor using water-soluble tetrahydroxyphthalocyanine-reduced graphene oxide as an electrode sensitive material for the detection of acetaminophen

Method used

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  • Tetrahydroxy phthalocyanine zinc-reduced graphene oxide nano-composite as well as electrochemical sensor prepared from the same and application thereof
  • Tetrahydroxy phthalocyanine zinc-reduced graphene oxide nano-composite as well as electrochemical sensor prepared from the same and application thereof
  • Tetrahydroxy phthalocyanine zinc-reduced graphene oxide nano-composite as well as electrochemical sensor prepared from the same and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: Preparation of zinc tetrahydroxyphthalocyanine-reduced graphene oxide nanocomposite

[0035] (1) Preparation of 4-hydroxyphthalonitrile:

[0036] Weigh 0.1mol 4-nitrophthalonitrile, 0.1mol sodium nitrite and 0.1mol anhydrous potassium carbonate in a round bottom flask, add 40mL N,N-dimethylformamide (DMF) to dissolve, and Nitrogen was introduced for 1 h while stirring, and under the protection of nitrogen, it was placed on a constant temperature magnetic stirrer and heated to 120 ° C for 24 h. After the reaction was completed, it was cooled to room temperature, and then filtered under reduced pressure. At this time, the solution was reddish orange, and then poured into the filtrate Add concentrated hydrochloric acid to the solution, adjust the pH to between 2-3, seal the filtrate and place it at 4°C for 2-3 days, a large number of flocculent precipitates appear in the solution, filter under reduced pressure, and wash the precipitate with water to neutral , d...

Embodiment 2

[0041] Example 2: Characterization of zinc tetrahydroxyphthalocyanine

[0042] The prepared zinc tetrahydroxyphthalocyanine was characterized by ultraviolet absorption spectrum, fluorescence spectrum, infrared spectrum and hydrogen nuclear magnetic resonance spectrum. The results are as follows: figure 1 shown. From the UV absorption spectrum, it can be seen that ( figure 1 A), the characteristic absorption peak of phthalocyanine appeared at 680nm, and the fluorescence spectrum shows ( figure 1 B), 4-hydroxyphthalonitrile has no fluorescence emission peak, while tetrahydroxyphthalocyanine zinc has a typical fluorescence emission peak of phthalocyanine ring at 692nm, indicating that a complete phthalocyanine ring is formed. It can be seen from the infrared spectrum that ( figure 1 C), in the infrared spectrum of 4-nitrophthalonitrile (4-nitrophthalonitrile), at 1539cm -1 and 1356cm -1 There are two stretching vibration peaks of nitro, in 4-hydroxyphthalonitrile (4-hydroxyp...

Embodiment 3

[0043] Embodiment 3: the preparation of electrochemical sensor

[0044] (1) Glassy carbon electrode pretreatment: using 0.3 and 0.05 μM Al respectively 2 o 3 Polished glassy carbon electrode (GCE), ultrasonically cleaned with absolute ethanol and ultrapure water in turn, and dried at room temperature for later use;

[0045] (2) Mix the ZnPc-rGO nanocomposite solution with a 0.5% Nafion solution (Nafion D-520 dispersion) at a volume ratio of 1:1, and apply 5 μL of the mixed solution onto the surface of the pretreated glassy carbon electrode. Dry at room temperature to obtain a ZnPc-rGO nanocomposite modified glassy carbon electrode, which is the ZnPc-rGO electrochemical sensor prepared in the present invention.

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Abstract

The invention discloses a tetrahydroxy phthalocyanine zinc-reduced graphene oxide nano-composite as well as an electrochemical sensor prepared from the tetrahydroxy phthalocyanine zinc-reduced graphene oxide nano-composite and application of the tetrahydroxy phthalocyanine zinc-reduced graphene oxide nano-composite. The tetrahydroxy zinc phthalocyanine-reduced graphene oxide nano composite is formed by combining water-soluble tetrahydroxy zinc phthalocyanine and reduced graphene oxide large pi bonds through non-covalent bonds. The combination of the two improves the disadvantage of poor dispersibility of the two while giving consideration to the advantages of the two, and has the advantages of large specific surface area, good conductivity, strong stability, easy availability, no toxicityand environmental friendliness. The Nafion tetrahydroxy phthalocyanine zinc-reduced graphene oxide nanocomposite is directly coated on the surface of a glassy carbon electrode through a one-step dispensing method, and the method has the advantages of being rapid and simple to operate, good in reproducibility and the like. The prepared sensor is low in cost, good in stability and selectivity, capable of achieving accurate, rapid and high-sensitivity detection of acetaminophen and wide in detection range, the detection limit is as low as 10 nmol / L, and the sensor has potential application valuein the fields of clinical diagnosis, drug analysis and the like.

Description

technical field [0001] The invention relates to a water-soluble zinc tetrahydroxyphthalocyanine-reduced graphene oxide nanocomposite and an electrochemical sensor prepared therefrom and its application, belonging to the technical field of electrochemistry and nanometer materials. Background technique [0002] Acetaminophen (AC) is a commonly used antipyretic and analgesic drug, which is widely used in clinical treatment. It is relatively safe to take normal doses of drugs, but excessive application can lead to severe liver toxicity and nephrotoxicity and even death. At the same time, long-term and extensive use and abuse, metabolized into the environment will also cause certain pollution to water sources. [0003] At present, the detection methods of acetaminophen mainly include liquid chromatography, gas chromatography, liquid chromatography-mass spectrometry and other technologies, but these technical methods are relatively time-consuming and laborious, the operation is c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/30
CPCG01N27/308
Inventor 史艳梅胡锴张俊霞晁利芹陈志红曹明卓
Owner HENAN UNIV OF CHINESE MEDICINE
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