Preparation method and applications of base self-assembly based strong-toughness self-repairing adhesive hydrogel material

A hydrogel and self-assembly technology, applied in applications, pharmaceutical formulations, surgical adhesives, etc., can solve structural instability and other problems, and achieve the effects of excellent adhesion performance, large output, and wide sources

Active Publication Date: 2020-09-04
湖北康晟医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, there are relatively few literatures on the hydrogels formed by base-pair hydrogen bond assembly, and most of the hydrogels with base-pair hydrogen bond interaction in the literature are the introduction of bases into the ends of polymer chains. , the gel is formed through the directional arrangement and stacking between the segments, and its structure is unstable

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  • Preparation method and applications of base self-assembly based strong-toughness self-repairing adhesive hydrogel material

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preparation example Construction

[0033] A method for preparing a strong and tough self-repairing tissue adhesion hydrogel material based on base self-assembly, including the following steps:

[0034] S1 uses 2-acrylamide-2-methylpropanesulfonic acid, AIBN, and DMSO to react to prepare poly(2-acrylamide-2-methylpropanesulfonic acid) (PAMPS);

[0035] S2 After the prepolymer obtained in step S1 is heated to 60°C, CDI is added to react for 3 hours, and finally adenine A is added to react for 5 hours respectively, the resulting products are subjected to dialysis treatment, and the resulting products are vacuum dried at 70°C for use;

[0036] S3 Add photoinitiator and crosslinking agent to the mixed solution of polymer containing different base units, 2% NaCl solution and cationic monomer methacryloxyethyltrimethylammonium chloride obtained in step S2, and ultrasonic Dissolve it completely, let it stand for a few minutes after argon gas, and finally transfer it to the PTFE template;

[0037] S4 Place the plastic sheet on ...

Embodiment 1

[0055] Step 1: The molar mass of AIBN is 2% of the molar mass of monomer AMPS, the solvent is DMSO, and the solid content is 10%. The calculated amount of 2-acrylamide-2-methylpropanesulfonic acid and 90g DMSO are added to the three-necked flask and stirred The temperature was increased to 75°C, nitrogen was added and half of the calculated amount of AIBN was added, and the reaction was carried out for 6 hours. After 6 hours of reaction, add a quarter of the calculated amount of AIBN and react for 3 hours. After reacting for 3 hours, add the calculated amount of remaining AIBN to react for 3 hours. After the reaction is completed, the obtained poly(2-acrylamide-2-methylpropanesulfonic acid) is collected for use;

[0056] Step 2: Poly(2-acrylamide-2-methylpropanesulfonic acid): carbonyl diimidazole (CDI): A(T) is 10:1.1:1. The calculated amount of 2-acrylamide-2-methylpropanesulfonic acid solution was added to the three-necked flask, the temperature was raised to 60°C, the calcu...

Embodiment 2

[0059] Step 1: The molar mass of AIBN is 2% of the molar mass of monomer AMPS, the solvent is DMSO, and the solid content is 10%. The calculated amount of 2-acrylamide-2-methylpropanesulfonic acid and 90g DMSO are added to the three-necked flask and stirred The temperature was increased to 75°C, nitrogen was added and half of the calculated amount of AIBN was added, and the reaction was carried out for 6 hours. After 6 hours of reaction, add a quarter of the calculated amount of AIBN and react for 3 hours. After reacting for 3 hours, add the calculated amount of remaining AIBN to react for 3 hours. After the reaction is completed, the obtained poly(2-acrylamide-2-methylpropanesulfonic acid) is collected for use;

[0060] Step 2: Poly(2-acrylamide-2-methylpropanesulfonic acid): carbonyl diimidazole (CDI): A(T) is 10:2.2:2. The calculated amount of 2-acrylamide-2-methylpropanesulfonic acid solution was added to the three-necked flask, the temperature was raised to 60°C, the calcu...

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Abstract

The invention discloses a base self-assembly based strong-toughness self-repairing adhesive hydrogel material. Strong-toughness self-repairing adhesive hydrogel is successfully synthesized by the method of free radical copolymerization initiated by ultraviolet. The hydrogel material obtained by a preparation method has excellent mechanical properties, self-repairing properties and adhesion properties. Through the introduction of base pairs, the hydrogel can be good in tissue adhesion; the mechanical properties of the hydrogel can be enhanced by regulating the effects and content of different base pairs; and the self-repairing properties of the hydrogel material can be realized through base pair hydrogen bond cross-linking and dissociation mechanism. The tensile strength of the prepared hydrogel material is 144 kPa, and the elongation at break is 293.3%; and the hydrogel material has significant adhesion properties on almost all kinds of materials and biological tissue including timber,iron, aluminum, poly(tetrafluoroethylene), plastic, glass, and the hearts, livers, spleens, lungs and kidneys of mice, and has 70% of self-healing properties under mild conditions.

Description

Technical field [0001] The invention relates to the field of hydrogels, in particular to a preparation method and application of a strong and tough self-repairing tissue adhesion hydrogel material based on base self-assembly. Background technique [0002] Hydrogel refers to a kind of crosslinked polymer with hydrophilic group, which can be swelled by water but is insoluble in water and has a three-dimensional network structure. The hydrogel material has soft properties, high water content and biocompatibility. It is widely used in cosmetics, ophthalmic materials, biomedicine and other fields. However, traditional polymer hydrogels are formed by covalent cross-linking of natural polymers or synthetic polymer monomers through simple chemical bonds. In the covalently cross-linked network structure, due to the uneven distribution of cross-linked links, The mechanical properties of the hydrogel are relatively poor. As the application of hydrogels becomes more and more widespread, si...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L26/00A61L24/06A61L24/00C08F265/10C08F220/34C08F222/38C08F2/48
CPCA61L26/0014A61L26/008A61L26/0061A61L24/06A61L24/0031A61L24/001C08F265/10C08F2/48A61L2400/04C08L51/003C08F220/34
Inventor 张全元张浩谢壮徐祖顺
Owner 湖北康晟医药有限公司
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