Composite probiotic composition for inhibiting helicobacter pylori and application of composite probiotic composition

A technology of Helicobacter pylori and compound probiotics, which is applied in the field of biomedicine to achieve the effect of increasing the eradication rate and enhancing the ability to resist Hp

Pending Publication Date: 2020-09-08
上海利康精准医疗技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] And about the compound probiotic preparation of the present invention, there is no report yet

Method used

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  • Composite probiotic composition for inhibiting helicobacter pylori and application of composite probiotic composition
  • Composite probiotic composition for inhibiting helicobacter pylori and application of composite probiotic composition
  • Composite probiotic composition for inhibiting helicobacter pylori and application of composite probiotic composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] This embodiment provides a compound probiotic composition for inhibiting Helicobacter pylori, the formula is:

[0037]

[0038]

[0039] Among them, the preparation method of the licorice extract is as follows: crush the licorice raw material, pass through a 40-mesh sieve, add a volume fraction of 75% ethanol to soak for 8 hours according to the ratio of material to liquid 1:10, filter, add 8 times the amount of 75% ethanol to the filter residue for reflux extraction, and filter . The filtrates were combined, concentrated under reduced pressure, and dried at 60°C until the crude drug content was 0.5 g / mg.

[0040] The preparation method of strawberry extract is as follows: fresh strawberries are beaten into a paste with a blender, and the volume fraction of 80% ethanol is added according to the ratio of material to liquid 1:10, and the volume fraction is refluxed for 2 hours, and a total of two extractions are made. Down drying until the crude drug content is 0.5...

Embodiment 2

[0042] This embodiment provides a compound probiotic composition for inhibiting Helicobacter pylori, the formula is:

[0043] components content fructooligosaccharide 160mg resistant dextrin 400mg Galactooligosaccharides 300mg Licorice Extract 12mg strawberry extract 4mg Maltodextrin 1067.34mg Lactobacillus reuteri powder 16.66mg, of which the number of viable bacteria is 2×10 10 CFU

Lactobacillus johnsonii powder 40mg, of which the number of live bacteria is 8×10 10 CFU

total weight 2g

[0044] Among them, the preparation method of the licorice extract is as follows: crush the licorice raw material, pass through a 40-mesh sieve, add a volume fraction of 75% ethanol to soak for 8 hours according to the ratio of material to liquid 1:10, filter, add 8 times the amount of 75% ethanol to the filter residue for reflux extraction, and filter . The filtrates were combined, concentrated under reduced ...

Embodiment 3

[0047] This embodiment provides a compound probiotic composition for inhibiting Helicobacter pylori, the formula is:

[0048] components content fructooligosaccharide 80mg resistant dextrin 500mg Galactooligosaccharides 300mg Licorice Extract 8mg strawberry extract 6mg Maltodextrin 1037.67mg Lactobacillus reuteri powder 33.33mg, of which the number of viable bacteria is 4×10 10 CFU

Lactobacillus johnsonii powder 35mg, of which the number of live bacteria is 7×10 10 CFU

total weight 2g

[0049] Among them, the preparation method of the licorice extract is as follows: crush the licorice raw material, pass through a 40-mesh sieve, add a volume fraction of 75% ethanol to soak for 8 hours according to the ratio of material to liquid 1:10, filter, add 8 times the amount of 75% ethanol to the filter residue for reflux extraction, and filter . The filtrates were combined, concentrated under reduced pr...

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Abstract

The invention provides a composite probiotic composition for inhibiting helicobacter pylori and an application of the composite probiotic composition. The composite probiotic composition comprises lactobacillus reuteri with a viable count of 1-2*10<10> CFU/g and lactobacillus johnsonii with a viable count of 3-4*10<10> CFU/g, and comprises the following other components in parts by weight: 80 to 160 parts of fructo-oligosaccharide, 400 to 600 parts of resistant dextrin, 200 to 400 parts of galactooligosaccharide, 8 to 12 parts of a liquorice root extract, 4 to 6 parts of a strawberry extract,and the balance of maltodextrin, wherein the total amount of the composition is 2000 parts. Probiotics contained in the composite probiotic composition are high in helicobacter pylori inhibiting capacity, the added components are beneficial to field planting of the probiotics and improvement of activity of the probiotics, and the stomach environment can be remarkably improved, so that helicobacterpylori can be effectively eradicated, and the composite probiotic composition has great application potential in the aspect of treating diseases caused by helicobacter pylori.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a compound probiotic composition for inhibiting Helicobacter pylori and its application. Background technique [0002] Helicobacter pylori is closely related to diseases such as chronic gastritis, peptic ulcer, gastric cancer and gastric mucosa-associated lymphoid tissue lymphoma. In the list of carcinogens published by the International Agency for Research on Cancer of the World Health Organization, Hp is listed as I carcinogens. For the first-line treatment of Hp, from triple therapy to today’s quadruple therapy, antibiotics are unavoidably needed, which can easily lead to an imbalance of normal gastrointestinal flora, and patients have adverse reactions such as nausea, diarrhea, and abdominal pain. Use also induces the generation of drug-resistant bacteria. [0003] Compared with antibiotics, probiotics have obvious advantages in the treatment of Hp. Existing studies have shown t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P1/04A61P31/04A61P35/00A61K31/702A61K31/715A61K31/733A61K35/747
CPCA61K35/747A61K31/702A61K31/715A61K31/733A61K36/484A61K36/73A61P31/04A61P1/04A61P35/00A61K2300/00
Inventor 毛丹丹傅咏南卞雪莲王校
Owner 上海利康精准医疗技术有限公司
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