Surface-enhanced Raman spectrum substrate based on unilateral multi-window capillary tube as well as preparation method and application thereof

A surface-enhanced Raman and capillary technology, which is applied in the field of sensitive detection and analysis, can solve problems such as the order of magnitude decrease in detection signal intensity, interference with the normal detection of target molecules, and enhancement of capillary Raman signals. It achieves convenient assembly and sampling, removal of randomness and Uncertainty, the effect of improving the detection effect of SERS

Inactive Publication Date: 2020-09-18
陈简一
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the problem that the signal acquisition of the surface-enhanced Raman spectroscopy substrate of the capillary needs to pass through the side wall of the capillary twice, the optical signal is greatly attenuated, resulting in an order of magnitude decrease in the detection signal intensity; and the background pull of the capillary itself is greatly enhanced. Mann signal, while interfering with the normal detection of target molecules and other issues

Method used

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  • Surface-enhanced Raman spectrum substrate based on unilateral multi-window capillary tube as well as preparation method and application thereof
  • Surface-enhanced Raman spectrum substrate based on unilateral multi-window capillary tube as well as preparation method and application thereof
  • Surface-enhanced Raman spectrum substrate based on unilateral multi-window capillary tube as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] like figure 1 As shown, a surface-enhanced Raman spectroscopy substrate based on a single-sided multi-window capillary includes a capillary 1, a window 2 is opened on the side wall of the capillary 1, and a noble metal nanoparticle layer is decorated on the inner side wall of the capillary.

[0042] The details are as follows: select capillaries with inner diameters of 0.3mm, 0.5mm, 0.9mm, 1.2mm, etc., and use laser to drill holes on the side to form 3-9 windows with a diameter of 0.01mm-3mm. The spacing is 3-5mm. The capillary is far ultraviolet optical quartz glass, ultraviolet optical quartz glass, infrared optical quartz glass.

[0043]According to the window size range, it is divided into small holes: 1.00-3.00mm; secondary small holes: 0.40-1.00mm; super small holes: 0.1-0.40mm; micro holes: 0.01-0.10mm; you can choose the laser according to the size of the window diameter Pulse energy, pulse width, defocus amount, pulse laser repetition frequency, etc. For exa...

Embodiment 2

[0054] A method for preparing a surface-enhanced Raman spectroscopy substrate based on a single-sided multi-window capillary, the steps are as follows:

[0055] (1) Select a capillary with an inner diameter of 0.3mm, use a laser to drill holes on its side to form 3 windows, the diameter of the window is 0.01mm, and the distance between adjacent windows is 3; the capillary is made of far-ultraviolet optical quartz glass;

[0056] (2) Wrap 2 layers of parafilm around the window along the radial direction of the capillary to seal the window;

[0057] (3) The capillary after the treatment in step (2) is subjected to rich amination treatment; after the capillary is washed with ultrapure water and absolute ethanol for 3 times, the capillary is soaked in 3-aminopropyltrimethoxysilane (APTMS) solution, modify the inner wall of the capillary with a large number of amino groups, and finally drain the 3-aminopropyltrimethoxysilane solution;

[0058] (4) Use the capillary force of the ca...

Embodiment 3

[0060] A method for preparing a surface-enhanced Raman spectroscopy substrate based on a single-sided multi-window capillary, the steps are as follows:

[0061] (1) Select a capillary with an inner diameter of 0.9 mm, and use a laser to drill holes on its side to form 5 windows with a diameter of 1 mm and a distance between adjacent windows of 4 mm. The capillary is ultraviolet optical quartz glass;

[0062] (2) Use polyvinyl chloride film to wrap 2 layers around the window along the radial direction of the capillary to seal the window;

[0063] (3) The capillary after the treatment in step (2) is subjected to rich amination treatment; after the capillary is washed with ultrapure water and absolute ethanol for 3 times, the capillary is soaked in 3-aminopropyltrimethoxysilane (APTMS) solution, modify the inner wall of the capillary with a large number of amino groups, and finally drain the 3-aminopropyltrimethoxysilane solution;

[0064] (4) Use the capillary force of the cap...

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Abstract

The invention provides a single-side multi-window capillary surface enhanced Raman spectrum substrate which comprises a capillary, windows are formed in the side wall of the capillary, and the inner side wall of the capillary is modified with a noble metal nanoparticle layer. Meanwhile, the invention further discloses a preparation method and application of the surface enhanced Raman spectrum substrate, and detection of drug poisons, pesticide residues, pigments, environmental pollutants, illegal additives and the like can be achieved. According to the surface-enhanced Raman spectrum substrateof the unilateral multi-window capillary tube, light loss is greatly reduced, and a local electric field generated by incident light on the surface is enhanced to the maximum extent under the actionof planarization of the single-layer noble metal nanoparticles and coverage of signals of the capillary tube, so that efficient Raman signals can be obtained. Therefore, the sensitivity and the stability of SERS detection are ensured.

Description

technical field [0001] The invention belongs to the technical field of sensitive detection and analysis, and in particular relates to a surface-enhanced Raman spectrum substrate of a single-sided multi-window capillary, a preparation method and an application. Background technique [0002] As a traditional detection method, spectral detection has been widely used in actual detection. Raman spectroscopy is not only used for laboratory detection of drugs, but in recent years, the development of small Raman spectroscopy detectors has also been widely used for rapid on-site detection. Raman spectroscopy is a kind of scattering spectrum. By analyzing the scattering spectrum of different incident light frequencies, the molecular vibration and rotation information can be obtained for molecular structure research, but the signal is too weak, which will affect the detection results. Surface-enhanced Raman spectroscopy (SERS) technology is an important means of trace analysis and dete...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 陈简一
Owner 陈简一
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