Extraction method of piceatannol in rhubarb medicinal materials, microcapsule molecular embedding method and application of piceatannol in cosmetics

A technology of piceatanol and its extraction method, which is applied in the direction of cosmetics, microcapsule preparations, cosmetic preparations, etc., can solve the problems of easy oxidative discoloration, affecting the absorption effect of the human body, and poor water solubility of molecules, so as to achieve protection and oxidative discoloration, and improve Effect of embedding rate, water solubility, and low skin sensitization

Inactive Publication Date: 2020-09-25
昆明翔昊科技有限公司
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Problems solved by technology

[0006] This application provides an extraction method of piceatanol in rhubarb medicinal materials, a microcapsule molecular embedding method and its application in cosmetics, which are used to solve the problem of poor water solubility of existing natural piceatanol molecules, which are used for When used in food and cosmetic products, it is easy to oxidize, change color, separate out, and affect the technical problems of human body's absorption effect

Method used

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  • Extraction method of piceatannol in rhubarb medicinal materials, microcapsule molecular embedding method and application of piceatannol in cosmetics
  • Extraction method of piceatannol in rhubarb medicinal materials, microcapsule molecular embedding method and application of piceatannol in cosmetics
  • Extraction method of piceatannol in rhubarb medicinal materials, microcapsule molecular embedding method and application of piceatannol in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1 extracts picetanol crystals from rhubarb in Lhasa

[0046] First, crush 1000 carats rhubarb dried rhizomes into 20-mesh granules, weigh 15 grams of cellulase, 10 grams of amylase, 5 grams of pectinase and 100 grams of warm water at 42°C, mix the above three enzymes with water, and stir Spray it evenly on the plant material, and keep it in a 42°C incubator for 36 hours to carry out enzymatic treatment.

[0047] The aforementioned enzymolysis-treated plant material was taken out, sprayed with 10% sodium carbonate solution to adjust the pH of the material to 10, added 12 kg of 73% (v / v) alcohol, and used a microwave extraction process (microwave power 650W, extraction time 180s,) to The material is extracted at room temperature (25-30°C).

[0048] After filtering the extract, add an appropriate amount of 5% lactic acid aqueous solution to adjust the pH=7, concentrate under reduced pressure to form an extract, add 10 times of pure water to dissolve back to obt...

Embodiment 2

[0049] Example 2 Preparation of Microcapsule Molecular Embedding Body by Picetanol Crystals

[0050] 1. Preparation of glucosyl-β-cyclodextrin (Glu-β-CD):

[0051] Step 1. Mix 20% maltose syrup and β-cyclodextrin powder according to 4:1 to form a homogeneous slurry, add 1-3% (w / w) pullulanase by total weight, and 38°C, 60% relative humidity in a constant temperature and humidity box for 72 hours, then put the prepared sample in a 50°C constant temperature box for 2 hours to stop the enzyme conversion, and obtain an intermediate product: glucosyl-β-cyclodextrin slurry .

[0052] Step 2. Add 1-3% (w / w) glucoamylase to the glucosyl-β-cyclodextrin slurry material, stir and mix evenly, keep stirring in a constant temperature and humidity box at 40°C and a relative humidity of 60% for 48 hours , Glucosyl-β-cyclodextrin is hydrolyzed under the action of glucoamylase to generate glucose and glucosyl-β-cyclodextrin.

[0053] Step 3: UF4050 ultrafiltration membrane is used to purify ...

Embodiment 3

[0059] Example 3 Picetanol Microcapsule Molecular Embedding Body Made Face Cream

[0060] Face cream product containing natural picatanol microcapsule molecular embedding body microcapsule molecular embedding body and preparation method

[0061]

[0062]

[0063]

[0064] Evaluation of application effect: In view of the poor solubility of picetanol in water (0.3 g / liter of picetanol), in embodiment 1, picetanol is no longer added in the traditional way, but adopts modified ring The dextrin is firstly prepared and embedded into molecular microcapsule molecular embedding body microcapsule molecular embedding body, and the microcapsule molecular embedding body is diluted with water first, and picetanol microcapsule molecular embedding body microencapsulation is added from the water phase. Capsule molecular embedding body, in the emulsification process of cosmetics, the oil phase is further encapsulated relative to the water phase, forming a binary embedding structure of ...

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Abstract

The invention discloses a method for extracting piceatannol from rhubarb medicinal materials, a microcapsule molecule embedding method and application of piceatannol in cosmetics. The method for extracting piceatannol from rhubarb medicinal materials comprises the following steps: with rhubarb medicinal material powder as a raw material, spraying a compound enzyme solution to the raw material, andthen carrying out enzymolysis to obtain an zymolyte; adding a sodium carbonate solution with a concentration of 10 wt% into the zymolyte to adjust a pH value to 10, adding ethanol to form an alcohol-water system solvent, carrying out microwave extraction at normal temperature, performing filtering to obtain a filtrate, adding lactic acid water with a concentration of 5 wt% into the filtrate, andadjusting the pH value to 7; and conducting concentrating under reduced pressure to obtain an extract, redissolving the extract to obtain a water-insoluble white precipitate, and carrying out water washing and recrystallization on the white precipitate 1-3 times to obtain a crystalline substance, wherein the piceatannol content of the crystalline substance is greater than or equal to 98% (w/w). According to the method, rheum officinale medicinal materials are used as raw materials, a pH value adjusting reagent which is non-irritant to skin and mild in performance is adopted, strong base and hydrochloric acid are not needed, the content of piceatannol in extracted crystals is larger than 98%, and the obtained substance is particularly applicable to substances in cosmetics.

Description

technical field [0001] The application relates to an extraction method of piceatanol in rhubarb medicinal materials, a microcapsule molecular embedding method and its application in cosmetics, belonging to the field of traditional Chinese medicinal materials and cosmetics. Background technique [0002] Rhei Radix et Rhizoma (Rhei Radix et Rhizoma) is a kind of folk Tibetan medicine that has been used in Tibetan areas for thousands of years. The two most important classical medical books in Tibet, "Si Bu Yi Dian" and "Jingzhu Materia Medica" make reference to the use of this medicine. recorded in detail. At the same time, this medicine is also a traditional Chinese medicinal material. Its medicinal records first appeared in "Shen Nong's Herbal Classic". There are about 45 species of rhubarb plants. In traditional Chinese medicine applications, it is mainly used in addition to the rhubarb palmatum ( Rheum palmutum L.), Tanguticum Rhubarb (R..tonguticum Maxim.ex Balf.) and Med...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C37/84C07C39/21C07C37/68A61K8/11A61K8/34A61K8/73A61K8/9789C08B37/16B01J13/02A61Q19/00
CPCC07C37/84C07C37/68A61K8/9789A61K8/347A61K8/738A61K8/11A61Q19/00C08B37/0012B01J13/02A61K2800/56A61K2800/805A61K2800/81A61K2800/10C07C39/21
Inventor 尹开云胡琳吴明一任杨帆胡群方震东
Owner 昆明翔昊科技有限公司
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