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Active bioglass-loaded skin regeneration material and preparation method thereof

A bioglass and skin regeneration technology, applied in medical science, non-woven fabrics, filament/thread forming, etc., can solve unfavorable wound cell adhesion, growth and differentiation, poor moisturizing effect, increase patient hospitalization time and infection risk, etc. question

Active Publication Date: 2020-10-27
李丹荣
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it also has certain limitations, such as: poor moisturizing effect, low antibacterial performance, easy to adhere to the wound, not conducive to cell attachment, growth and differentiation of the wound surface, etc.
[0006] In addition, the vascularization rate of skin regeneration products is slow, and it usually takes several weeks (2-4 weeks) for the implant to fully vascularize, increasing the patient's hospital stay and risk of infection

Method used

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  • Active bioglass-loaded skin regeneration material and preparation method thereof
  • Active bioglass-loaded skin regeneration material and preparation method thereof
  • Active bioglass-loaded skin regeneration material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～10

[0040] In Examples 1-10, the preparation method of the skin regeneration material comprises the following steps:

[0041] (1) Stir and mix silk fibroin, chitosan, polyvinyl alcohol, active biological glass and hexafluoroisopropanol at room temperature, and the stirring rate is 400rpm / 24h to obtain an electrospinning solution; the silk fibroin, The ratio of the quality of chitosan, polyvinyl alcohol and active biological glass is shown in Table 1, and the ratio of the sum of the quality of described silk fibroin, chitosan, polyvinyl alcohol and active biological glass to the volume of hexafluoroisopropanol is: 1:10;

[0042] (2) The electrospinning solution was spun with an electrospinning machine at a temperature of 40°C, a humidity of 35%, a voltage of 25kV, and a push rate of 2mL / h to prepare skin regeneration materials, and the spinning time was 4h. The skin regeneration material was obtained.

[0043] Wherein, the preparation method of silk fibroin comprises the followin...

Embodiment 5

[0054] Image 6 14 days after operation, the skin regeneration materials of different embodiments repair the rat wound. Depend on Image 6 It can be seen that after the skin regeneration material treatment of Example 4, the wound area has been greatly reduced, and the wound is almost completely repaired, which is the fastest recovery among the five experimental examples. However, in Example 5, there were still small wounds at the defect site. In contrast, in the experimental groups of Example 1, Example 2 and Example 3, the repair of the burn wound was relatively slow, the degree of wound healing was low and a small amount of pus was still visible at the wound.

[0055] Figure 7 with 8 14 days after operation, H&E and Masson staining of skin regeneration materials in different embodiments on rat wound repair. comprehensive Figure 7 with 8 It can be seen that 14 days after the operation, the levels of inflammatory cells in the tissues of Examples 4 and 5 were very low,...

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Abstract

The invention discloses a preparation method of an active bioglass-loaded skin regeneration material. The preparation method comprises the steps of uniformly mixing silk fibroin, chitosan, polyvinyl alcohol, active bioglass and hexafluoroisopropanol, and carrying out electrostatic spinning to obtain the skin regeneration material, wherein the mass ratio of the silk fibroin to the chitosan to the polyvinyl alcohol to the active bioglass is 1: 0.1: 0.1: 0.1; the ratio of the mass sum of the silk fibroin, the chitosan, the polyvinyl alcohol and the active bioglass to the volume of the hexafluoroisopropanol is 1: (8-12). The skin regeneration material prepared by the method disclosed by the invention has the mechanical properties of high tensile stress, high Young modulus, low elongation at break and the like and high water absorptivity, can promote vascularization of a wound surface and shorten the healing time of the wound surface, and is a skin substitute with good performance.

Description

technical field [0001] The invention relates to a biomedical material, in particular to a skin regeneration material loaded with active bioglass and a preparation method thereof. Background technique [0002] The skin is the largest organ of the human body, mainly composed of the epidermis, dermis and subcutaneous tissue, and is also rich in blood vessels and nerves. In daily life, due to various reasons such as trauma, burns, ulcers, surgery and congenital deformities, it is easy to cause skin defects. Although skin tissue has a strong regenerative ability, for large-area full-thickness skin defects, the regenerative ability of the skin is obviously insufficient due to the loss of the dermis. The key to treating full-thickness skin defects is to rebuild and regenerate dermal tissue, promote early wound closure, and avoid complications such as microbial invasion. So far, autologous skin grafting is still the most effective method for clinical treatment of full-thickness sk...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/60A61L27/54A61L27/10A61L27/22A61L27/16A61L27/50D01D5/00D04H1/728
CPCA61L27/10A61L27/16A61L27/227A61L27/50A61L27/54A61L27/60A61L2300/10A61L2300/232A61L2300/404A61L2300/412D01D5/003D01D5/0069D01D5/0092D04H1/728C08L89/00C08L29/04
Inventor 李丹荣
Owner 李丹荣
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