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Oral cavity washing liquid and preparation method thereof

A technology for washing liquid and oral cavity, which is applied in the field of oral washing liquid, can solve the problems of low compliance and inaccurate curative effect, etc., and achieves good market prospects, improves compliance, and reduces precipitation.

Active Publication Date: 2020-11-10
鲁可
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there have been reports on the treatment of oral diseases with Ainaxiang, but it has defects such as inaccurate curative effect and low compliance.

Method used

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  • Oral cavity washing liquid and preparation method thereof
  • Oral cavity washing liquid and preparation method thereof
  • Oral cavity washing liquid and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The impact of embodiment 1 bulk drug proportioning on antibacterial effect

[0023] The raw material ratio of each sample is shown in the table below:

[0024] The raw material formula of each sample of table 1

[0025]

[0026]

[0027] Weigh the medicinal material according to the above ratio, add 10 times the temperature of water and soak for 3 hours, filter, and the filtrate is rotary evaporated to dryness, then dissolved in glycerin, and prepared into a medicinal solution with a concentration of 25, 12.5, 6.25, 3.125, 1.5625 mg / ml by the ratio dilution method .

[0028] Dissolve Streptococcus mutans, Staphylococcus, and Candida albicans in broth culture solution respectively, and prepare a concentration of 10 8 cfu / ml bacterial suspension.

[0029] Pipette 0.5ml of different concentrations of the drug solution under each sample number into a 96-well microwell plate, add 0.1ml of bacterial suspension to each well, blow and mix with a pipette gun, and then p...

Embodiment 2

[0040] Embodiment 2 extraction solvent screening test

[0041] Ainaxiang 700g, skullcap leaves 1100g, philodendron leaves 500g

[0042] 1) Take Ainaxiang, scutellaria baicalensis leaves, and phobia leaves, add 15Kg of water, heat to 85°C and soak for 1.5 hours, filter, collect the extract, add 10Kg of water to the dregs, heat to 85°C, soak for 1.5 hours, filter , collect the extract, combine the two extracts and concentrate into a clear paste with a relative density of 1.25;

[0043] 2) Divide the clear ointment into 9 parts on average by weight, one of which is not subjected to any treatment as a blank control, and the remaining 8 parts are added with methanol, propylene glycol, n-butanol, ethyl acetate, tetrahydrofuran, ether, chloroform, and petroleum ether respectively. Extraction, separation of the organic phase and concentration into a clear paste with a relative density of 1.35;

[0044] 3) The clear paste was dried under pressure to constant weight, and the contents ...

Embodiment 3

[0050] Ainaxiang 700g, skullcap leaves 1100g, philodendron leaves 500g

[0051] 1) Take Ainaxiang, add 5Kg of water to distill for 8 hours, collect the essential oil and store it in another container for later use;

[0052] 2) Take Scutellaria baicalensis leaves and philodendron chinensis leaves, add them to the medicinal residues after distillation in step 1), add water and heat to 80°C for warm soaking and extracting 3 times, the amount of water added each time is 8Kg, the extraction time is 0.5 hours, filter and combine The three extractions are concentrated into a clear paste with a relative density of 1.25;

[0053] 3) adding tetrahydrofuran to the clear paste of step 2) for extraction, separating the organic phase and concentrating into a clear paste with a relative density of 1.35;

[0054] 4) add distilled water earlier in the clear paste of step 3), then add standby volatile oil and 0.05% (volume) Tween 80, 1% (volume) glycerin, 0.1% (weight) sodium benzoate, stirrin...

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Abstract

The invention discloses oral cavity washing liquid. The oral cavity washing liquid is prepared from three raw materials including blumea balsamifera herb, scutellaria baicalensis leaves and camptotheca acuminate leaves in a weight ratio of (4-12):(6-15):(2-8). The invention further discloses a preparation method of the oral cavity washing liquid. The washing liquid provided by the invention has arelatively good inhibition effect on common oral pathogenic bacteria such as streptococcus mutans, staphylococcus and candida albicans, can be used for preventing and treating diseases such as oral ulcer, stomatitis, caries and oral lichen, and has the effects of cleaning the oral cavity, inhibiting bacteria, removing odor, refreshing breath and the like.

Description

technical field [0001] The invention relates to an oral rinse, and also relates to a preparation method thereof. Background technique [0002] Due to the increasing consumption of tobacco, alcohol and spicy food, as well as the decline of autoimmunity caused by fatigue, irregular life and high pressure, the incidence of oral diseases such as oral ulcers, stomatitis, dental caries, oral moss and bad breath is increasing. The consumption of oral care products and medicines is also increasing year by year. Studies have shown that these oral diseases are closely related to the imbalance of microbial flora in the oral cavity. Most of the existing drugs play a role in treatment and health care by clearing away heat and detoxification, antibacterial and anti-inflammatory. [0003] Ainaxiang is a perennial herb or subshrub of the genus Ainaxiang in the family Asteraceae. The whole herb is used as medicine. It has various pharmacological effects such as sweating and eliminating phle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/9789A61Q11/00
CPCA61K8/9789A61Q11/00
Inventor 鲁可
Owner 鲁可
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