Preparation method of fructose sodium diphosphate powder injection

A technology of sodium fructose diphosphate and powder injection, which is applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc. It can solve the problems of high equipment requirements, poor absorbability, poor stability, etc., and achieve improved yield and quality Stability, economical production process, and the effect of reducing allergenicity
CN112110964AInactive Publication Date: 2020-12-22HAINAN HUALON PHARM
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Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Applications(China)
Current Assignee / Owner
HAINAN HUALON PHARM
Publication Date
2020-12-22
Estimated Expiration
Not applicable ยท inactive patent

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Abstract

The invention discloses a preparation method of a fructose sodium diphosphate powder injection. According to the method, the yield and quality stability of fructose sodium diphosphate are effectivelyimproved by adopting the modes such as accurately proportioning a ratio of a solute and a solvent, adjusting an addition amount of ethanol, and controlling crystallization temperature and stirring speed in the preparation process. According to the preparation method, seed crystals do not need to be added in the recrystallization process, and the preparation method has the advantages of simple andconvenient operations and simplified production steps. The purity of fructose sodium diphosphate produced by the preparation method is also improved, and the sensitization of fructose sodium diphosphate is reduced.
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Description

Technical field

[0001] The present invention belongs to the field of pharmacy. More specifically, the present invention relates to a method for refining crude sodium fructose diphosphate, which can be used to prepare sodium fructose diphosphate powder injection.Background technique

[0002] Fructose 1,6-diphosphate (FDP) is a cellular metabolite that exists in the human body and can regulate the activity of various enzymes in glucose metabolism. Exogenous fructose diphosphate can increase the concentration of adenosine triphosphate and creatine phosphate in cells, promote potassium influx, increase the content of diphosphoglycerate in red blood cells, inhibit oxygen free radicals and histamine release and other pharmacological effects, and can reduce The damage of the body caused by ischemia and hypoxia, especially for ischemic heart disease, shows a good protective effect. Both fructose diphosphate and glucose have the effect of directly supplying heat energy, replenishing body fluids an...

Claims

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