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Composition for female cleansers comprising natural extract

A technology of composition and cleaning agent, which is applied in the direction of drug combination, medical preparations containing active ingredients, skin care preparations, etc. It can solve the problems of rising total iodine value, hypothyroidism, difficult to expect therapeutic and preventive effects, etc.

Pending Publication Date: 2021-01-19
INVENTAGE LAB INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is known that the chemically synthesized disinfectant povidone-iodine has effects on the prevention and treatment of candida vaginitis, trichomonas vaginitis and other vaginal infection inflammations, but it may cause allergic symptoms such as iodine or due to mucous membrane Itching, burning sensation, skin ulcers, contact dermatitis, etc. caused by injury, the increase in the value of inorganic iodine in the vagina or the total iodine in the blood will induce hypothyroidism
[0007] The prior art for eliminating the side effects caused by the use of antiseptics as pharmaceuticals as described above is based on the secretion of lactic acid by beneficial microorganisms in the vagina in healthy women to maintain the acidity in the vagina at pH 3.2, at this low acidity , which inhibits proliferation or kills most harmful bacteria, proposes a pH 3.5 buffer solution preparation containing lactic acid as the main component and adding whey (lactoserum) extracted from milk, but instead of calling it feminine cleansing It is better to say that it is a suitable acidity maintenance agent in the vagina that keeps the pH of the vagina in a normal state, and it is difficult to expect fundamental therapeutic and preventive effects.

Method used

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  • Composition for female cleansers comprising natural extract
  • Composition for female cleansers comprising natural extract
  • Composition for female cleansers comprising natural extract

Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0079] [Preparation Example: Preparation of Composition for Feminine Cleanser]

[0080] 1. Preparation of composition for feminine cleanser

[0081] Pulverize propolis, collagen peptide, black yeast, chitosan, angelica extract, centella asiatica extract and grapefruit seed extract with a mixer, and sieve it with a 30 mesh (mesh) sieve to prepare the first mixture, and will serve as excipients SMCC90, starch Starch1500, microcrystalline cellulose PH102, mannitol 160C, ascorbic acid as a water-soluble vitamin, and crospovidone CL-SF as a disintegrant were put into a 30-mesh sieve to prepare the second mixture.

[0082] The prepared first mixture and the second mixture were mixed, and 0.89% by weight of magnesium stearate was added as a lubricant, mixed and tabletted to prepare a composition for feminine cleanser.

[0083] The preparation is carried out according to the more specific contents shown in Table 1 below.

[0084] 【Table 1】

[0085]

[0086] (unit: % by weight,...

experiment example 1

[0092] [Experimental example 1: Evaluation of antibacterial power against Candida albicans]

[0093] Each 100 μl of pre-cultured Candida albicans (Candida albicans) was subpackaged on the plate medium (Sabouraud Dextrose Agar.Difco.USA) for disc diffusion method detection and smeared, and the prepared The compositions for feminine cleansers of the test numbers IV1 to 10 and IT1 to 6 were dropped on the samples in a paper plate at a concentration of 5 mg / disk, and then placed on the culture medium.

[0094] As a control group, itraconazole (Itraconazol), which is an antifungal agent, was dropped on the sample on the paper sheet at a concentration of 100 μg / sheet, and then placed on the medium. After culturing the plate medium at 28° C. for 48 hours, the size of the growth inhibition zone (Clean Zone: clean zone) was measured. The results are shown in Table 3.

[0095] As shown in Table 3 below, the feminine cleansing composition of the present invention exhibited a strong gro...

experiment example 2

[0101] [Experimental example 2: Itching reduction effect experiment]

[0102] Select 80 women aged 20 to 40 who feel itching, and divide them into 16 groups, 5 people in each group, let them use the feminine cleanser composition of Experiment Nos. IV1 to 10 and IT1 to 6 diluted in water for 10 days , the anti-itching effect was evaluated, and the results are shown in Table 4. The score ranges from 10 to 1, and a higher score indicates a better anti-itch effect.

[0103] 【Table 4】

[0104]

[0105]

[0106] As shown in the above-mentioned Table 4, it was confirmed that IT1 to IT6 further containing Angelica dahurica extract, Seombadi extract, and Euphorbia extract were excellent in reducing itching, and IT3 to IT6 showed the most excellent reducing itching effect.

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PUM

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Abstract

The present invention relates to a composition for female cleansers comprising a natural extract. The composition for female cleansers comprising the natural extract comprises propolis, collagen peptide, black yeast, chitosan, the natural extract selected from the group consisting of an angelica sinensis extract, a centella asiatica extract, a grapefruit seed extract, and mixtures thereof; and a water-soluble vitamin. The composition has excellent effects of preventing and treating vaginal diseases, contains the natural extract, is hardly irritated during use, can provide a healthier environment, and has excellent antibacterial activity.

Description

technical field [0001] The present invention relates to feminine cleansing compositions comprising natural extracts. More specifically, it relates to a composition for a feminine cleanser for preventing and treating vaginal-related diseases in women, containing a natural extract as a main component. Background technique [0002] The female vagina is the connecting passage between the vulva and the uterus, and is the most humid and warm place in the female body. Since the environment is suitable for the bacteria and molds that are the main cause of vaginitis, the possibility of disease from this is high. Under normal conditions, there are a large number of lactic acid bacteria inhabiting the inside of the vagina to make the inside of the vagina weakly acidic, thereby inhibiting the proliferation of pathogenic bacteria or molds, but due to long-term use of antibiotics or contraceptives, use of tampons or contraceptive rings, or pregnancy or childbirth When the balance of fem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61K36/752A61K35/644A61K36/064A61K36/23A61K36/232A61K47/36A61K47/38A61P15/02A61P31/04A61P31/10A61K31/375A61K31/4188A61K31/4415A61K31/455A61K31/51A61K31/519A61K31/525A61K31/714A61K31/722
CPCA61K35/644A61K38/39A61K36/064A61K31/722A61K36/232A61K36/23A61K36/752A61K31/375A61K31/51A61K31/525A61K31/455A61K31/4415A61K31/714A61K31/519A61K31/4188A61K47/38A61K47/36A61P15/02A61P31/10A61P31/04A61K2300/00A61K8/988A61K8/65A61K8/9728A61K8/736A61K8/9789A61K8/676A61K8/673A61Q19/10A61Q17/005A61K36/062A61K9/0034A61K9/20A61K2800/5922
Inventor 金株希柳忠昊金世延
Owner INVENTAGE LAB INC
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