Targeted nano-vaccine preparation based on metal-polyphenol network structure and product of targeted nano-vaccine preparation

A network structure and nano-vaccine technology, applied in the field of targeted nano-vaccine preparation and its products, nano-vaccine preparation and its products, can solve the weak response of antigen-specific cytotoxic T lymphocytes and increase the escape function of nano-particle lysosomes , affecting biocompatibility and in vivo safety and other issues, to achieve the effects of enhancing cellular uptake, improving targeting and lysosomal escape efficiency, and improving vaccine delivery efficiency
CN112245407AInactive Publication Date: 2021-01-22SHANDONG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANDONG UNIV
Publication Date
2021-01-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a preparation method of a targeted nano vaccine based on a metal-polyphenol network structure. The preparation method comprises the following steps that mesoporous silica nanoparticles loaded with ovalbumin OVA are prepared, mannose-modified tannic acid molecules are synthesized, and the surfaces of the mesoporous silica nanoparticles loaded with the ovalbumin OVA are coated with metal-polyphenol network coatings, so that the mesoporous silica nanoparticles loaded with the OVA and with the surfaces coated with the metal-polyphenol network coatings are obtained, therefore the targeted nano-vaccine based on the metal-polyphenol network structures is obtained, and the targeted nano-vaccine is named as MS@OVA@MPN@Man. According to the preparation method, the surfaces are coated with the metal-polyphenol network coatings, so that leakage of OVA is prevented, and the lysosome escape function of the nanoparticles is increased; and meanwhile, mannose is modified on thesurface to target a mannose receptor on the surface of an immune cell, so that the uptake capacity of the cell to the mannose receptor is enhanced to improve the vaccine delivery efficiency, and the problems of targeting of the nano vaccine and lysosome escape efficiency are solved.
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Description

technical field

[0001] The invention relates to a preparation of a nano-vaccine and its product, in particular to a preparation of a targeted nano-vaccine based on a metal-polyphenol network structure and its product, and belongs to the technical field of nano-materials and biomedicine. Background technique

[0002] Nanotechnology is the commanding height of scientific and technological development in the 21st century and the leading technology of the new industrial revolution. Due to their unique structural, magnetic, mechanical and size effects, nanoparticles are widely used in fields including biosensing, drug delivery, bioimaging, catalysis, nanofabrication, lubrication, electronics, textiles, etc. One of the current research hotspots is to study and explore various nanoparticle systems used in the biomedical field, especially nanoparticles used in tumor therapy, including mesoporous silica, metal nanoparticles, magnetic oxides, and quantum dots. and other inorganic nan...

Claims

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