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Preparation method of subminiature magnetic ferroferric oxide nanoparticles

A technology of ferroferric oxide and nanoparticles, applied in the direction of iron oxide/hydroxide, nanotechnology, nanotechnology, etc., can solve the problems of difficult control of nucleation and growth process, and achieve low raw material cost, easy control, size uniform effect

Active Publication Date: 2021-04-16
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the problem that the nucleation and growth process of the reported ultra-small magnetic iron ferric oxide nanoparticles is difficult to control, the present invention provides a method for preparing ultra-small magnetic iron ferric oxide nanoparticles
This method overcomes the difficulty of controlling the nucleation and growth process existing in the existing preparation methods, and can realize large-scale production, and has a wide range of applications in the field of biomedicine

Method used

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  • Preparation method of subminiature magnetic ferroferric oxide nanoparticles
  • Preparation method of subminiature magnetic ferroferric oxide nanoparticles
  • Preparation method of subminiature magnetic ferroferric oxide nanoparticles

Examples

Experimental program
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Embodiment 1

[0028] (1) Dissolve 5mmol ferric chloride in 25mL deionized water in beaker A.

[0029] (2) Dissolve 15mmol sodium hydroxide in 25mL deionized water in beaker B.

[0030] (3) Add the solution in the B beaker to the A beaker under the condition of magnetic stirring, and stir for 30 minutes to obtain brown ferrihydrite precipitation.

[0031] (4) Centrifuge the ferrihydrite precipitate, wash once with deionized water and absolute ethanol, pour off the supernatant, mix well with 50mL ethylene glycol, then transfer to a 250mL three-necked round-bottomed flask, and heat to boiling , and then keep boiling and refluxing for 12 hours, stop the reaction, and cool to room temperature to obtain a reaction solution containing ultra-small magnetic iron ferric oxide nanoparticles. Ultra-small magnetic iron ferric oxide nanoparticles are obtained through solid-liquid separation.

[0032] figure 1 Shown is the X-ray diffraction pattern (XRD) of ferrihydrite obtained in this embodiment, it ...

Embodiment 2

[0034] The difference between this embodiment and embodiment 1 is that the boiling reflux time in the step (4) is 30 minutes. Other method steps are identical with embodiment 1.

[0035] Image 6 Shown is a transmission electron microscope (TEM) image of the ultra-small magnetic iron ferric oxide nanoparticles obtained in this embodiment. It can be seen from the figure that the obtained iron ferric oxide nanoparticles are uniform in size, with an average particle diameter of about 2.5 nm.

Embodiment 3

[0037] The difference between this embodiment and embodiment 1 is that the boiling reflux time in the step (4) is 1 hour. Other method steps are identical with embodiment 1.

[0038] Figure 7Shown is a transmission electron microscope (TEM) image of the ultra-small magnetic iron ferric oxide nanoparticles obtained in this example. It can be seen from the figure that the obtained iron ferric oxide nanoparticles are uniform in size, with an average particle diameter of about 3.8 nm.

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Abstract

The invention discloses a preparation method of subminiature magnetic ferroferric oxide nano particles with the size smaller than 8nm, and relates to the technical field of nano material preparation. In order to overcome the defect that the nucleation and growth processes of the subminiature magnetic ferroferric oxide nanoparticles prepared by the existing method are difficult to control, ferrihydrite with a nano structure is used as a precursor, and is heated and reacted in polyhydric alcohols; and then the ultra-small magnetic ferroferric oxide nanoparticles which are uniform in size, controllable in particle size, good in crystallinity, high in purity and easy to dissolve in water are obtained. The preparation method comprises the following steps: 1) reacting ferric iron salt with an alkaline substance in an aqueous solution to obtain ferrihydrite precipitate; and 2) mixing the ferrihydrite precipitate with polyol, and heating to obtain the subminiature magnetic ferroferric oxide nanoparticles. The method has the advantages of readily available raw materials, low cost, simple process and suitability for large-scale production, and the obtained subminiature magnetic ferroferric oxide nanoparticles have wide application in the field of biomedicine.

Description

technical field [0001] The invention belongs to the technical field of nanomaterial preparation, and in particular relates to a preparation method of ultra-small magnetic iron ferric oxide nanoparticles. Background technique [0002] Magnetic iron ferric oxide nanoparticles have unique magnetic properties and good biocompatibility, and have a wide range of biomedical fields such as cell separation, targeted drug delivery, gene delivery, magnetic resonance imaging (MRI), and tumor magnetic hyperthermia. use. The magnetic properties and biological effects of Fe3O4 nanoparticles are closely related to the particle size and surface structure. The preparation of magnetic Fe3O4 nanoparticles with different sizes and surface structures is a necessary condition for various biomedical applications. Recent studies have shown that ultra-small magnetic ferric oxide nanoparticles with a size of less than 8nm have good T 1 The performance of magnetic resonance imaging has great applicat...

Claims

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Application Information

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IPC IPC(8): C01G49/08B82Y30/00B82Y40/00
Inventor 万家齐王宇飞张娇王镇张博雅陈克正
Owner QINGDAO UNIV OF SCI & TECH
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