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Application of cardamom in preparation of medicine for treating and delaying intervertebral disc degenerative change

A degenerative disease and intervertebral disc technology, which is applied in the field of application of cardamomin in the preparation of drugs for treating and delaying intervertebral disc degeneration, can solve the problems of no intervertebral disc degeneration, achieve obvious anti-inflammatory and anti-oxidation effects, The effect of low dose and inhibition of inflammatory response of nucleus pulposus cells

Active Publication Date: 2021-04-30
THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no clinically available drug for the treatment of intervertebral disc degeneration

Method used

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  • Application of cardamom in preparation of medicine for treating and delaying intervertebral disc degenerative change
  • Application of cardamom in preparation of medicine for treating and delaying intervertebral disc degenerative change
  • Application of cardamom in preparation of medicine for treating and delaying intervertebral disc degenerative change

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Embodiment 1

[0037] 1. Materials and reagents

[0038] Cell culture reagents (products of Life technologies): DMEM / F12 cell basal medium (10567-014, Gibco, Invitrogen, Grand Island, NY), fetal bovine serum, trypsin, 100U / ml penicillin / streptomycin (double antibody) . Other cell culture reagents: collagenase type II (Gibco).

[0039] Histological reagents (Beijing Suolaibao): hematoxylin, eosin; paraformaldehyde, paraffin, absolute ethanol, xylene, neutral resin. Cell Proliferation Detection Kit Cell Couming KIT-8 (CCK-8, Dojindo Laboratories, Kumamoto, Japan).

[0040] Western blotting and immunofluorescence reagents: Aggrecan, Collagen II, ADAMTS5, GAPDH and Lamin B1 (Abcam, Cambrige, UK), inos, COX-2, IκBα, p65, Nrf2, HO-1 and MMP13 were purchased from ProteinTech (Wuhan, China) , DAPI Fluoromount-GTM anti-fluorescence quenching mounting medium (Zhongshan Jinqiao), Goat anti-rabbit (Alexa Fluor488, Invitrogen), protein quantification kit BCAProtein Assay Kit), immunohistochemical endo...

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Abstract

The invention relates to application of cardamom in preparation of a medicine for treating and delaying intervertebral disc degenerative change. Amomum cardamomum is a plant extract with good biological activity, and it is found that Amomum cardamomum has the efficacy of inhibiting nucleus pulposus inflammatory response by up-regulating Nrf2, and has the characteristics of low dosage and obvious anti-inflammatory and antioxidant effects. Compared with western medicines, the cardamom serves as a traditional Chinese medicine, the anti-inflammatory effect of the cardamom is relatively mild, and an alternative treatment medicine can be provided for comprehensive treatment of the intervertebral disc degeneration disease.

Description

technical field [0001] The invention relates to the application of cardamomin in the preparation of medicines for treating and delaying degeneration of intervertebral discs. Background technique [0002] Low back pain (LBP) is a common clinical disease. Epidemiological data show that nearly 80% of humans experience at least one episode of LBP in their lifetime, and IVDD is considered to be the main cause. However, there is currently no clinically available drug for the treatment of intervertebral disc degeneration. [0003] Intervertebral disc degeneration is a multifactorial process, such as abnormal stress, local nutrient deficiency, and congenital genetic abnormalities, etc., and inflammation is one of the important pathogenesis of intervertebral disc degeneration, in which the extracellular matrix of nucleus pulposus cells mediated by inflammatory factors ( Extracellular matrix (ECM) anabolic disorder is a critical link in the process of intervertebral disc degeneration...

Claims

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Application Information

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IPC IPC(8): A61K31/12A61P19/08A61P29/00A61K36/9064
CPCA61K31/12A61K36/9064A61P19/08A61P29/00
Inventor 谢成龙王向阳张小磊黄其杉胡孙理吴弘强郑刚马海伟施益锋
Owner THE SECOND HOSPITAL AFFILIATED TO WENZHOU MEDICAL COLLEGE
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