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Method for rapidly synthesizing high-fluorescence sulfur quantum dots

A sulfur quantum and fluorescence technology, applied in fluorescence/phosphorescence, chemical instruments and methods, sulfur preparation/purification, etc., can solve the problems of complicated operation steps, time-consuming sulfur quantum dots, low fluorescence quantum yield, etc. Application prospect, high yield, good photostabilization effect

Active Publication Date: 2021-05-28
CENT SOUTH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Based on the defects existing in the prior art, the object of the present invention is to provide a preparation method and application of sulfur quantum dots. The raw materials of the preparation method are easy to obtain, the price is low, and the preparation method is simple, which can solve the problem of the preparation of sulfur quantum dots in the prior art. The time is long, the operation steps are loaded down with trivial details, the problems such as low fluorescent quantum yield; The advantage of the present invention is to provide green economy, fast preparation, easy operation, high fluorescent quantum yield and has wide application potential

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  • Method for rapidly synthesizing high-fluorescence sulfur quantum dots
  • Method for rapidly synthesizing high-fluorescence sulfur quantum dots
  • Method for rapidly synthesizing high-fluorescence sulfur quantum dots

Examples

Experimental program
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Embodiment 1

[0033] At room temperature, 1g sulfur powder, 5g Na 2 S and 0.1 g BSA, 50 mL H 2 0 was placed in a round-bottomed flask and sonicated for 10 min;

[0034] (2) The reaction temperature was set to 90°C, the reaction time was 5h, and after the reaction was completed, it was naturally cooled to room temperature.

[0035] (3) Perform centrifugation, and take the supernatant. In order to obtain pure sulfur quantum dots with uniform size distribution and removal of impurities such as unreacted raw materials, the supernatant after centrifugation was filtered three times through a microporous membrane or placed in a dialysis bag for dialysis. The filtrate or dialysate is heated, concentrated and dried in a vacuum drying box, and the obtained solid sulfur quantum dots are soluble in water and other solvents to meet the needs of different applications.

[0036] figure 1 TEM image of the sulfur quantum dots prepared in Example 1. Depend on figure 1 It can be seen that the particle s...

Embodiment 2

[0042] The sulfur quantum dots prepared in Example 1 were subjected to surface modification treatment. The specific method is:

[0043] At room temperature, 100 μL of hydrazine hydrate was added to 20 mL of sulfur quantum dot solution, and the reaction was stirred for 1 h. The optical properties of the obtained surface-modified sulfur quantum dots were characterized, which proved that they had the ability of biological imaging.

[0044] The modified sulfur quantum dots are used for cell fluorescence imaging. Due to their high fluorescence quantum yield and good biocompatibility, they show brighter fluorescence signals in cells.

Embodiment 3

[0046] The sulfur quantum dots prepared in Example 1 were subjected to surface modification treatment. The specific method is:

[0047] At room temperature, 10 μL of 0.1M glucose oxidase (GOx) was added to 20 mL of sulfur quantum dot solution, and the reaction was stirred for 1 h, and the obtained sulfur quantum dots were used for tumor treatment.

[0048] Loaded GOx can consume glucose in the body to produce H 2 O 2 , resulting in the effect of starvation healing.

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Abstract

The invention provides a method for rapidly synthesizing strong fluorescence sulfur quantum dots. The preparation method comprises the following steps: adding powdered sulfur and metal sulfide into a dispersion system to obtain dispersion liquid, wherein the dispersion system comprises protein and water; introducing oxidizing gas into the system, and carrying out stirring reaction under a heating condition; and after the reaction is finished, cooling to room temperature, and carrying out purification treatment through centrifugation, filtration and dialysis to obtain the sulfur quantum dots. According to the invention, the method for preparing the sulfur quantum dots through oxidation of the oxidizing gas has the advantages of being short in reaction time, high in fluorescence quantum yield, rich in surface functional groups, relatively uniform in particle size distribution, good in water solubility and biocompatibility, high in stability and the like, and has great application potential and significance in numerous fields.

Description

technical field [0001] The invention belongs to the technical field of nanomaterials, and relates to a synthesis method for preparing strong fluorescent sulfur quantum dots by utilizing oxidative gas oxidation and protein passivation. Background technique [0002] Sulfur quantum dots are dispersed spherical fluorescent sulfur nanoparticles with a size in the nanometer scale. Sulfur quantum dots prepared from sulfur powder and protein exhibit good chemiluminescence properties such as high fluorescence intensity, high photostability, resistance to photobleaching, and low toxicity, and can be used in various fields such as detection, catalysis, imaging, and therapy. [0003] At present, cheap and easily available, green and environmentally friendly synthetic raw materials, simple and fast preparation methods, and sulfur quantum dots with high quantum yield and red / near-infrared emission need to be further developed and studied. However, so far, there have been only a few studi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/56C09K11/02B82Y20/00B82Y40/00G01N21/64C01B17/027C01B17/06A61K38/44A61K41/00A61K47/55A61K47/64A61K49/00A61P35/00
CPCC09K11/56C09K11/025B82Y20/00B82Y40/00G01N21/643C01B17/027C01B17/06A61K49/0067A61K38/443A61K47/64A61K47/55A61K41/0052C12Y101/03004A61P35/00G01N2021/6432
Inventor 蓝敏焕李香草赵少静
Owner CENT SOUTH UNIV
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