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Preparation method of hollow mesoporous silica double-drug sustained release microspheres for osteoporosis treatment

A technology of hollow mesoporous silica, which is applied in drug combination, drug delivery, and pharmaceutical formulations, can solve the problems of easy drug resistance in the body, low drug load, and affect the therapeutic effect, so as to promote osteocyte Proliferation, promote efficient bone repair and regeneration, and improve the effect of treatment

Active Publication Date: 2021-06-22
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The prevention and treatment strategy of osteoporosis aims to inhibit excessive bone resorption and increase bone formation, but the traditional oral or injection methods have disadvantages such as low drug availability, easy drug resistance, gastrointestinal diseases, and renal toxicity.
Therefore, the use of microspheres as the slow-release carrier of drugs can increase drug availability and reduce adverse effects on the body, but this method still has low drug load, too fast drug release, and the body is prone to drug resistance. Sex and other problems, affecting the treatment effect

Method used

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  • Preparation method of hollow mesoporous silica double-drug sustained release microspheres for osteoporosis treatment
  • Preparation method of hollow mesoporous silica double-drug sustained release microspheres for osteoporosis treatment
  • Preparation method of hollow mesoporous silica double-drug sustained release microspheres for osteoporosis treatment

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Embodiment 1

[0036] A method for preparing hollow mesoporous silicon dioxide double-drug slow-release microspheres for osteoporosis treatment, comprising the steps of:

[0037] 1) Prepare a mixed solution with water, ethanol, resorcinol and formaldehyde according to the volume ratio of 40:15:0.2:0.5, specifically, dissolve resorcinol and formaldehyde in the mixed solvent of water and ethanol according to the above ratio , reacted at 40°C, 200r / min mechanical stirring conditions for 12h, then continued to react at 200°C for 24h by hydrothermal method, cooled, centrifuged, washed and dried to obtain nano-phenolic resin microspheres as templates, The microscopic morphology of the microspheres is figure 1 shown by figure 1 It can be seen that the surface of the microspheres is smooth and the size is uniform;

[0038]2) Mix the nano-phenolic resin microspheres and cetyltrimethylammonium bromide as template agent according to the mass ratio of 1:1, disperse them in the mixed solvent of water a...

Embodiment 2

[0046] A method for preparing hollow mesoporous silicon dioxide double-drug slow-release microspheres for osteoporosis treatment, comprising the steps of:

[0047] 1) Prepare a mixed solution with water, ethanol, resorcinol and formaldehyde according to the volume ratio of 40:15:0.2:0.5, specifically, dissolve resorcinol and formaldehyde in the mixed solvent of water and ethanol according to the above ratio , reacted at 40°C, 200r / min mechanical stirring conditions for 12h, and then continued to react at 200°C for 24h by hydrothermal method, cooled, centrifuged, washed and dried, and used as template nano-phenolic resin microspheres;

[0048] 2) Mix the nano-phenolic resin microspheres and cetyltrimethylammonium bromide as template agent according to the mass ratio of 1:1, disperse them in the mixed solvent of water and ethanol, stir and add tetraethyl orthosilicate and Ammonia, wherein the volume ratio of water, ethanol, tetraethyl orthosilicate and ammonia is 30:10:0.3:0.8, ...

Embodiment 3

[0058] A method for preparing hollow mesoporous silicon dioxide double-drug slow-release microspheres for osteoporosis treatment, comprising the steps of:

[0059] 1) Prepare a mixed solution with water, ethanol, resorcinol and formaldehyde according to the volume ratio of 40:15:0.1:0.4, specifically, dissolve resorcinol and formaldehyde in the mixed solvent of water and ethanol according to the above ratio , reacted at 40°C and 200r / min mechanical stirring for 12h, then continued to react at 220°C for 24h by hydrothermal method, cooled, centrifuged, washed and dried, and prepared nano-phenolic resin microspheres as a template ;

[0060] 2) Mix nano-phenolic resin microspheres and cetyltrimethylammonium bromide as a template agent according to a mass ratio of 1:2, disperse them in a mixed solvent of water and ethanol, stir and add tetraethyl orthosilicate and Ammonia, wherein the volume ratio of water, ethanol, tetraethyl orthosilicate and ammonia is 30:10:0.3:0.8, react at 4...

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Abstract

The invention provides a preparation method of hollow mesoporous silica double-drug sustained release microspheres for osteoporosis treatment. The preparation method comprises the following steps: preparing phenolic resin microspheres with uniform particle size in advance by using a hydrothermal method, and then coating the surface with shell silica through hydrolysis-polycondensation by using the phenolic resin microspheres as a template to obtain the core-shell structure microspheres with phenolic resin microsphere as the core and silicon dioxide as the shell; then removing the phenolic resin microspheres as the core through calcination to obtain hollow mesoporous silicon dioxide microspheres, activating hydroxyl groups on the surfaces of the hollow mesoporous silicon dioxide microspheres so as to graft an osteoporosis treatment drug, and loading another drug in the inner cavity of the microspheres. The surface-activated hollow mesoporous silica microspheres are used for a drug carrier, and have the advantages of controllable drug release rate, good biocompatibility, high drug loading rate and encapsulation efficiency, long-acting sustained release of drugs and the like; through combined application of the two medicines, bone formation can be promoted while the activity and function of osteoclast are effectively inhibited, drug resistance of the body can be avoided, and the treatment effect is improved.

Description

technical field [0001] The invention relates to the technical field of preparation of biomedical materials, in particular to a method for preparing hollow mesoporous silicon dioxide double-drug sustained-release microspheres for osteoporosis treatment. Background technique [0002] Osteoporosis is a systemic skeletal disease characterized by loss of bone mass and destruction of bone microstructure, which eventually leads to increased bone fragility and susceptibility to fracture. It mainly includes primary osteoporosis, secondary osteoporosis and idiopathic osteoporosis. The clinical manifestations are pain, spinal deformation, fragility fracture, etc. It is one of the epidemics in the 21st century, causing huge medical and social economic burden. [0003] The prevention and treatment strategy of osteoporosis aims to inhibit excessive bone resorption and increase bone formation, but the traditional oral or injection methods have disadvantages such as low drug availability, ...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K9/16A61K47/04A61K31/663A61K38/29A61K31/381A61K31/7048A61P19/10
CPCA61K47/6923A61K9/1611A61P19/10A61K31/663A61K38/29A61K31/381A61K31/7048A61K2300/00
Inventor 戴红莲赵雅楠庄彭真刘家玮郭嘉欣
Owner WUHAN UNIV OF TECH
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