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Fibroin polylactic acid porous nanofiber composite material as well as preparation method and application thereof

A nanofiber and composite material technology, applied in silk fiber production, fiber processing, hollow filament manufacturing, etc., can solve the problems of uneven separation of nanofibers, inability to achieve single fiber surface structure, improvement, etc. Specific surface area and roughness, favorable adhesion and proliferation, short production cycle effects

Active Publication Date: 2021-06-29
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing direct ultrasound of silk fibers will cause uneven fiber splitting of nanofibers; there are also applications of ultrasound in the preparation of hydrogels, but the preparation cycle is very long; currently there are reports that ultrasound is applied to electrospinning, such as ultrasonic treatment The influence of the pore size of polylactic acid / silk fibroin composite nanofiber membrane (Journal of Zhejiang Sci-tech University (Natural Science Edition), Volume 33, Issue 6, November 2015), the literature reported that the membrane obtained by electrospinning Ultrasonic treatment of the composite membrane makes the nanofibers more loosely packed and the pore size increases, but its main purpose is to disperse between fibers and increase the pore size between fibers, but it is impossible to improve the structure of the surface of a single fiber

Method used

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  • Fibroin polylactic acid porous nanofiber composite material as well as preparation method and application thereof
  • Fibroin polylactic acid porous nanofiber composite material as well as preparation method and application thereof
  • Fibroin polylactic acid porous nanofiber composite material as well as preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] 1. Set the temperature at 25°C and the humidity at 30% RH. After removing the pupae and impurities from the silkworm cocoon, cut the cocoon shell into pieces.

[0044] 2. Weigh 5g of shredded silkworm cocoons, put them into 2L of 0.21wt% sodium bicarbonate boiling aqueous solution for degumming treatment for 30min, wash them repeatedly with deionized water for 3 times, and then move them to a ventilated place to dry naturally. Degummed silkworm silk can be obtained.

[0045] 3. Configure a calcium chloride-formic acid solution with a calcium chloride concentration of 4wt%, weigh 23g of the solution, place it in a 50mL centrifuge tube, and then add 2g of degummed silkworm silk to the solution for dissolution in stages to obtain the mass Fraction 8% silkworm silk protein solution.

[0046] 4. Filter the silkworm silk protein solution with a PTFE microporous filter membrane with a pore size of 0.45 μm, and collect the filtrate in a new centrifuge tube for subsequent use. ...

Embodiment 2

[0078] 1. Set the temperature at 20°C and the humidity at 15% RH. After removing the pupa and impurities from the silkworm cocoon, cut the cocoon shell into pieces.

[0079] 2. Weigh 5g of shredded silkworm cocoons, put them into 2L of 0.21wt% sodium bicarbonate boiling aqueous solution for degumming treatment for 40min, wash them repeatedly with deionized water for 3 times, and then move them to a ventilated place to dry naturally. Degummed silkworm silk can be obtained.

[0080] 3. Prepare a calcium chloride-formic acid solution with a calcium chloride concentration of 2wt%, weigh 20g of the solution, place it in a 50mL centrifuge tube, and then dissolve 0.2g of degummed silkworm silk in the solution to obtain the mass fraction 1% silkworm silk protein solution.

[0081] 4. Filter the silkworm silk protein solution with a PTFE microporous filter membrane with a pore size of 0.45 μm, and collect the filtrate in a new centrifuge tube for subsequent use.

[0082] 5. Weigh 0.2...

Embodiment 3

[0086] 1. Set the temperature at 35°C and the humidity at 40% RH. After removing the pupa and impurities from the silkworm cocoon, cut the cocoon shell into pieces.

[0087] 2. Weigh 5g of shredded silkworm cocoons, put them into 2L of 0.21wt% sodium bicarbonate boiling aqueous solution for degumming treatment for 40min, wash them repeatedly with deionized water for 3 times, and then move them to a ventilated place to dry naturally. Degummed silkworm silk can be obtained.

[0088] 3. Configure a calcium chloride-formic acid solution with a calcium chloride concentration of 35 wt%, weigh 30 g of the solution, place it in a 50 mL centrifuge tube, and then dissolve 5 g of degummed silkworm silk in the solution to obtain a mass fraction of 16.7 % silkworm silk protein solution.

[0089] 4. Filter the silkworm silk protein solution with a PTFE microporous filter membrane with a pore size of 2 μm, and collect the filtrate in a new centrifuge tube for subsequent use.

[0090] 5. We...

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Abstract

The invention discloses a fibroin polylactic acid porous nanofiber composite material and a preparation method and application thereof. The preparation method comprises the following steps: cutting cocoon shells into pieces to be subjected to degumming treatment, adding degummed domestic silkworm silk into a calcium chloride / formic acid solution to obtain a domestic silkworm silk protein solution, filtering the domestic silkworm silk protein solution, adding filtrate into a polylactic acid solution to be evenly mixed, and performing ultrasonic treatment; and performing electrospinning treatment on a fibroin polylactic acid solution subjected to ultrasonic treatment to obtain the fibroin polylactic acid porous nanofiber composite material. The preparation process is convenient to operate, low in production cost, short in production period and environmentally friendly, the prepared fibroin polylactic acid composite nanofiber membrane has a specific fiber morphology, and a specific hole structure and a secondary structure exist on a single fiber, and thus the requirements for different properties of materials are met; The fibroin polylactic acid porous nanofiber composite material can be applied to wound dressings, tissue engineering scaffold materials, and drug delivery and transfer materials.

Description

technical field [0001] The invention belongs to silk nanofibers, and relates to a silk polylactic acid porous nanofiber composite material and its preparation method and application. [0002] technical background [0003] With the progress of science and technology and society, new materials and nanotechnology have been developed rapidly. Since the fibers produced by traditional processes will cause a lot of waste of resources and environmental pollution, the topics of sustainable development, environmental protection and the use of renewable resources are attracting more and more attention. Silk fibroin derived from natural silk has broad application prospects in the fields of tissue engineering, food packaging, and environmental protection due to its good biocompatibility and degradability. However, regenerated silk fibroin has disadvantages such as poor mechanical properties, crosslinking and electrical conductivity. In order to overcome the defects and deficiencies of a...

Claims

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Application Information

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IPC IPC(8): D04H1/728D01D5/00D01B7/00D01C3/02D01F1/08D01F8/02D01F8/14A61L15/32A61L15/26A61L15/42A61L27/26A61L27/56A61K9/70A61K47/34A61K47/42
CPCD04H1/728D01D5/003D01B7/00D01C3/02D01F1/08D01F8/02D01F8/14A61L15/425A61L15/225A61L27/26A61L27/56A61K9/70A61K47/34A61K47/42D10B2509/06D10B2509/022A61L2400/12C08L89/00C08L67/04Y02W90/10
Inventor 王昉蔡博文刘浩
Owner NANJING NORMAL UNIVERSITY
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