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Weak acid cation resin for extracting vitamin B12 and synthesis method thereof

A cation resin, B12 technology, applied in the fields of medicine and chemical industry, can solve the problems of inability to guarantee the removal of specific impurities, incomplete elution, small adsorption capacity, etc., achieve good mechanical strength and anti-oxidation performance, low resin transformation expansion rate, The effect of large adsorption capacity

Active Publication Date: 2021-07-09
SHAANXI LANSHEN SPECIAL RESIN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Weak acid resin for water treatment on the market, VB 12 The adsorption capacity is small, the elution is not complete, and the removal of specific impurities cannot be guaranteed. Therefore, it is necessary to develop a 12 Special weak acid cation resin for purification requirements

Method used

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  • Weak acid cation resin for extracting vitamin B12 and synthesis method thereof

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preparation example Construction

[0033] A kind of weak acid cation resin for extracting vitamin B12 of the present invention and synthetic method thereof, comprises the following steps:

[0034] S1. Add the dispersant and the aqueous phase inhibitor to the saline, the mass volume ratio of the dispersant: the aqueous phase inhibitor: the saline = 0.05~0.50: 0.0005~0.0010: 100, and the density of the saline is d=1.15~ 1.18g / ml (NaCl content = 20% ~ 24%), heat up and stir to make a water phase; mix the monomer, porogen and initiator evenly to make an oil phase; add the oil phase to the water phase and let it stand After 15 minutes, after the oil phase and the water phase are completely separated, control the stirring speed to adjust the particle size of the oil phase, and then carry out segmental heat preservation operation to complete the polymerization reaction; after the reaction, extract and recover the porogen by water vapor, wash with water, and dry. Sieve to obtain the weak acid cation resin precursor-whi...

Embodiment 1

[0048] In a 3000ml three-necked bottle, add 1200ml of salt water (d=1.18g / ml), 60g of 5% hydroxyethyl cellulose solution, 12ml of 0.1% methylene blue aqueous solution, stir well, and heat up to 40°C for later use . Add 191.1g of methyl methacrylate, 127.5g of methyl acrylate, 34.2g of 63.0% divinylbenzene, 7.2g of TAIC, 7.2g of benzoyl peroxide, and 216g of 200# gasoline into a 1000ml beaker. After stirring evenly, add In the three-neck bottle, let it stand for 10 minutes. After the oil-water phase layering is stable, start stirring to beat the particle size, and control the particle size range to 0.38mm. Raise the temperature to 65°C at a rate of 2°C / 10 minutes, keep the temperature for 3 hours, raise the temperature to 75°C, keep the temperature for 3 hours, raise the temperature to 95°C, and keep the temperature for 6 hours. Cool down and wash the balls. Put the white balls into the water vapor extractor, pass through the water vapor at 105°C, blow off and recover the por...

Embodiment 2

[0052] In a 3000ml three-necked bottle, add 1200ml of salt water (d=1.15g / ml), 60g of 5% hydroxyethyl cellulose solution, 12ml of 0.1% methylene blue aqueous solution, stir well, and heat up to 40°C for later use . Add 16.2g of methyl methacrylate, 307.1g of methyl acrylate, 45.7g of 63.0% divinylbenzene, 7.2g of TAIC, 7.2g of benzoyl peroxide, 126g of 200# gasoline, and 72g of toluene into a 1000ml beaker, and stir well Finally, add it to the three-necked bottle and let it stand for 10 minutes. After the oil-water phase is separated and stabilized, start stirring to beat the particle size, and control the particle size range to 0.4mm. Raise the temperature to 65°C at a rate of 2°C / 10 minutes, keep the temperature for 3 hours, raise the temperature to 85°C, keep the temperature for 3 hours, raise the temperature to 95°C, and keep the temperature for 6 hours. Cool down and wash the balls. Put the white balls into the water vapor extractor, pass through the water vapor at 106°...

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Abstract

The invention discloses weak acid cation resin for extracting vitamin B12 and a synthesis method thereof. The synthesis method comprises the following steps: adding a dispersing agent and a water-phase polymerization inhibitor into salt water, heating and stirring to prepare a water phase; uniformly mixing a monomer, a pore-foaming agent and an initiator to prepare an oil phase; adding the oil phase into the water phase, adjusting the granularity of the oil phase after the oil phase and the water phase are completely layered, then carrying out sectional heat preservation, introducing water vapor to extract and recover the pore-foaming agent after the reaction is finished, and then sequentially washing with water, drying and screening to obtain a weak acid cation resin precursor; adding a NaOH solution into the weak acid cation resin precursor, heating to 95 DEG C in stages, cooling after heat preservation hydrolysis, carrying out suction filtration to recover alkali liquor, washing with water until the pH value is less than or equal to 9, neutralizing with an HCl solution until the pH value is less than or equal to 2, washing with water until the pH value is neutral, and washing with reverse osmosis pure water until the effluent COD is qualified to obtain the weak acid cation resin. The resin is low in transformation expansion rate, high in mechanical strength and good in oxidation resistance.

Description

technical field [0001] The invention belongs to the technical fields of chemical industry and medicine, and in particular relates to a weak acid cation resin for extracting vitamin B12 and a synthesis method thereof. Background technique [0002] Vitamin B 12 (referred to as VB 12 ) is a red crystalline powder, odorless and tasteless, soluble in water, ethanol and acetone, insoluble in chloroform and ether, easy to decompose in strong acid or alkaline solution, most stable under weak acid conditions (pH4.5~5.0), It has certain heat resistance under weakly acidic or neutral conditions. VB in nature 12 All are synthesized by microorganisms, and higher animals and plants cannot produce VB by themselves. 12 . VB 12 It can promote the development and maturation of red blood cells in the human body, maintain the body's hematopoietic function, and prevent pernicious anemia. It also maintains the health of the nervous system and promotes the metabolism of carbohydrates, fats,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30B01D15/08
CPCB01J20/264B01J20/28019B01D15/08
Inventor 张运梅昂冯志军张红攀刘耀龙孙冰杰
Owner SHAANXI LANSHEN SPECIAL RESIN
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