Medical dressing containing recombinant humanized collagen, and preparation method
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A technology of human collagen and raw materials, applied in medical science, bandages, etc., can solve the problems of unfavorable recovery of affected areas, skin irritation, inconvenient use, etc., and achieve the effect of reducing the chance of wound infection, reducing wound pain, and convenient use
Inactive Publication Date: 2021-07-16
山东慕驰生物医药科技有限公司
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[0004] The purpose of the present invention is to solve the problem that most of the existing dressings are fixed on the skin by coating medical glue on the fixed film, and the coating of medical glue on the fixed film is usually full-width coating, which is inconvenient to use. and other problems, and it has a certain irritation to the skin, especially some sensitive skins will cause allergies, which is not conducive to the recovery of the affected area, and a medical dressing containing recombinant human collagen and its preparation method are proposed.
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Embodiment 1
[0056] A medical dressing containing recombinant human collagen, consisting of the following raw materials in percentage by weight:
[0057] Recombinant human collagen 0.5%-1.5%
[0058] Ceramide 3%-7%
[0059] Niacinamide 2%-6%
[0060] Medical Chitosan 0.6%-1%
[0061] Ginseng Extract 0.5%-1.5%
[0062] Chamomile Extract 0.2%-0.6%
[0063] Purslane Extract 0.3%-0.7%
[0064] Aloe Vera Extract 0.1%-0.5%
[0065] Natural Lactic Acid 0.1%-0.3%
[0066] Polyhexamethylene biguanide 0.1‰-0.5‰
[0067] Carbomer 0.3%-0.7%
[0068] Propylene Glycol 3%-7%
[0069] Glycerin 1%-5%
[0070] Triethanolamine 0.05%-0.15%
[0071] The remaining purified water.
[0072]In the present invention, recombinant human collagen is reverse-transcribed human collagen mRNA into cDNA through bioengineering technology, and a section of gene recombination after enzyme digestion and high-density fermentation, separation, renaturation, and purification processes in Escherichia coli A kind of hi...
Embodiment 2
[0075] A medical dressing containing recombinant human collagen, consisting of the following raw materials in percentage by weight:
[0076] In the present invention, the recombinant human collagen 1% is reverse-transcribed human collagen mRNA into cDNA through bioengineering technology, and a section of gene recombination after enzyme digestion and high-density fermentation in E.coli (Escherichia coli) , separation, renaturation, and purification process to produce a high-molecular-weight biological protein. The molecular weight of collagen is 1500-3000 Daltons, which is easier to be absorbed by the human body. Among them, collagen with a molecular weight of about 2000 Daltons is the most stable and easily absorbed. Absorbed by the human body, 5 leading advantages of recombinant human collagen: high repairability: promote the growth of fibroblasts; high safety: the results of genetic engineering research, no virus hidden dangers, no rejection; high moisture retention: soluble ...
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Abstract
The invention discloses a medical dressing containing recombinant humanized collagen. The medical dressing consists of the following raw materials in parts by weight: 0.5-1.5% of recombinant humanized collagen, 3-7% of ceramide, 2-6% of nicotinamide, 0.6-1% of medical chitosan, 0.5-1.5% of ginseng radix extracts, 0.2-0.6% of chamomilla extract, 0.3-0.7% of herba portulacae extract, 0.1-0.5% of aloe extract, 0.1-0.3% of natural lactic acid, 0.01-0.05% of polyhexamethylene guanidine, 0.3-0.7% of Carbomer, 3-7% of propylene glycol, 1-5% of glycerol, 0.05-0.15% of triethanolamine and the balance of purified water. The invention also puts forward a preparation method of the medical dressing containing the recombinant humanized collagen. The medical dressing disclosed by the invention has the performance of bacteria resistance, repairing, high biocompatibility and high cell affinity, has the excellent functions of water permeation, ventilation, moisture absorption, wound surface infection reduction and quick lightening of wound pain, has the efficacy of wound surface repairing, aging skin firming and senility resisting, water replenishing, allergy resisting and skin beautifying for the skin of the human body, also can be used for bacteria resisting, cleaning and anti-aging repairing of the female vulva and vagina and is used for accelerating vagina health.
Description
technical field [0001] The invention relates to the technical field of medical dressings, in particular to a medical dressing containing recombinant human collagen and a preparation method thereof. Background technique [0002] Medical dressings in the traditional concept refer to medical materials used to cover sores, wounds or other skin injuries. After the skin is injured by trauma, burns, abscesses, etc., it will cause a series of problems in the body, such as bacterial infection, moisture and protein. Excessive loss, endocrine and immune dysfunction, etc., may be life-threatening in severe cases. Therefore, after skin damage, it is usually necessary to use a skin substitute medical dressing to protect the wound, prevent wound infection and severe dehydration, and provide a moist environment conducive to wound healing. , to promote wound healing. [0003] Clinically, most of the existing dressings are fixed on the skin by coating medical glue on the fixed film. Coating ...
Claims
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