A kind of hyaluronidase inhibitor and preparation method thereof

Abstract

The invention discloses a hyaluronidase inhibitor and a preparation method thereof. Adenosine heptapeptide MATGNAD is used to prepare hyaluronidase inhibitor, and the mass fraction of adenosine heptapeptide in hyaluronidase inhibitor is 90%. Scale industrial production. The hyaluronidase inhibitor has high inhibition efficiency against hyaluronidase, small side effects, high temperature resistance, high humidity resistance, and good stability, and can be used for preparing hyaluronic acid products, which are used in skin care products, feed additives, and biological veterinary drugs. , food additives and other aspects have broad application prospects.

Description

technical field [0001] The invention relates to a hyaluronidase inhibitor and a preparation method thereof, belonging to the fields of feed additives, biological veterinary drugs and cosmetic additives. [0002] technical background [0003] Hyaluronidase (HAase), also known as diffusion factor, is a hydrolase of hyaluronic acid, which can degrade hyaluronic acid in tissues, thereby improving the fluid permeability in tissues. There are two types of hyaluronidase in the human body: endogenous and exogenous. Endogenous hyaluronidase is mainly produced by the animal body itself. Endogenous hyaluronidase is a participant in allergic reactions. Hyaluronidase has a strong correlation with inflammation and allergy. Histamine released by various mast cells can regulate hyaluronidase activity, thereby increasing tissue permeability. Inflammation and allergic reactions are induced, so hyaluronidase is an important research object for anti-inflammatory and anti-allergic (Hu Guosheng, ...

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Problems solved by technology

Cactus celery extract, asiaticoside, vine tea flavonoids and irisin are several common hyaluronidase inhibitors, which can reduce the degradation of hyaluronic acid by inhibiting hyaluronidase activity and ensure the hyaluronic acid in the dermis The acid content, thereby improving the moisturizing effect of the skin, and has a corresponding effect on allergies, and has important applications in cosmetics, health products and medicines (Hu Guosheng, using an in vitro inflammatory response model to measure the anti-inflammatory effects of various Chinese herbal ingredients, Proceedings of the 2002 China Cosmetics Symposium; Sun Peidong, Liu Chao, Wang Xiaohong, Research on the inhibitory effect of irisin on hyaluronidase, Chemical Bulletin, 2013, 857-860; Wang Xiaohong, Sun Peidong, Yang Liuqing, etc. Inhibition of Hyaluronidase by Phytochemicals, Proceedings of the Ninth China Cosmetics Symposium, 2012; CN201710705705.7 A kind of irisin with anti-allergy and moisturizing activity and its preparation method and application), but these plant extracts Due to the constraints of different production areas, different seasons and other factors, the content of active ingredients in different batches varies greatly, the purity is not high, the inhibitory effect on hyaluronic acid is not strong, and the effect is unstable

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