New ganoderma lucidum strain ZL167 and new application thereof

A kind of Ganoderma lucidum, application technology, applied in Ganoderma lucidum new strain ZL167 and its application field

Active Publication Date: 2021-08-20
SICHUAN ACAD OF CHINESE MEDICINE SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although there are many studies on the immune-related mechanism of Ganoderma lucidum polysaccharides, there is no report on the promotion of T cell tumor infiltration by Ganoderma lucidum polysaccharides.

Method used

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  • New ganoderma lucidum strain ZL167 and new application thereof
  • New ganoderma lucidum strain ZL167 and new application thereof
  • New ganoderma lucidum strain ZL167 and new application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1 embodiment, the embodiment of the present invention strains of Ganoderma lucidum

[0033] Ganoderma species of the present invention is derived from a parent Emeishan a wild fungus (Ganoderma lucidum (Leyss.ex Fr.) Karst.). Which was isolated tissue, domestication and cultivation, high content screening of the medicinal ingredient Ganoderma species present invention ZL167, which is consistent with stable genetic traits, high yield fruiting body, excellent internal quality.

[0034] Main characteristics:

[0035] 1, appearance

[0036] With typical lucidum [Ganoderma lucidum (Leyss.ex Fr.) Karst.] Morphological characteristics. Fruiting body shape umbrella shaped, kidney-shaped cap, the diameter of 10-16cm, 1-2cm thick, rigid hull, reddish brown, shiny, with annular ribs clear, thin, flat truncated edge, ventral yellow-white, beige section .

[0037] Thick mycelium white, thick, having a lock-like joint, heterothallic binding.

[0038] Ganoderma spores oval to oval, long 9...

Embodiment 2

[0042] Preparation Example 2, Ganoderma lucidum polysaccharides embodiment of the present invention

[0043] After pulverizing Ganoderma lucidum Example 1, was added 20 volumes of distilled water, reflux extraction IH, filtered, and the filtrate was collected, residue extracted once repeated. Two filtrates were combined and concentrated under reduced pressure. Add 3 volumes of ethanol, 4 ℃ overnight, the precipitate was collected by centrifugation 10000rpm 10min. Precipitate was redissolved in distilled water, Sevag method employed to remove protein. The polysaccharide solution was added 3 volumes of absolute ethanol, 4 ℃ overnight, the precipitate was collected by centrifugation 10000rpm 10min. 50 ℃ dried, pulverized, Ganoderma lucidum polysaccharides, 4 ℃ stored for use. Sulfuric acid - anthrone method, the polysaccharide content of Ganoderma lucidum polysaccharides measurement sample prepared was 92.3%.

[0044] The beneficial effects of the present invention are demonstrated b...

experiment example 1

[0045] Experimental Example 1, a multi-point test results

[0046] Ganoderma lucidum No. 1 medicine (obtaining approval certificate Sichuan Crop Variety approval number: Chuan drug trial of Ganoderma species 2,009,005) for the control of Ganoderma strains ZL167 were varieties of multi-point test for two consecutive years and an annual production test.

[0047] 2015 and 2016, respectively, in the town of victory Emeishan City, Deyang City, the town of Tongji as a variety of comparative test results showed that:

[0048] 1, the production cycle: ZL167 production cycle of about 120 days, compared with the control drug 1 Ganoderma lucidum shortened compared to about 13 days.

[0049] 2, morphology: ZL167 hull hard, red-brown, shiny, with annular ribs clear, thin, flat truncated edge, ventral yellow-white, light brown section.

[0050] 3, Yield: planting the wood, ZL167 production are two ≥25g / kg of the wood (a tide), and the control drug species Ganoderma lucidum one equivalent.

[00...

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Abstract

The invention provides a new ganoderma lucidum strain ZL167 preserved in China General Microbiological Culture Collection Center (CGMCC), with a preservation number being CGMCC NO.22443. The invention further provides a new ganoderma lucidum polysaccharide extracted from the new ganoderma lucidum strain ZL167, and the ganoderma lucidum polysaccharide has the advantages that the expression of ICAM-1 in endothelial cells is increased by activating an NF-kappa B pathway; and T cell tumor infiltration can be further increased, thus playing a role of tumor inhibition. According to the invention, the ganoderma lucidum strain and the ganoderma lucidum polysaccharide have very excellent application value in the fields of food, health care products and medicines.

Description

Technical field [0001] The present invention belongs to the field of medicine, in particular to a new strain of Ganoderma ZL167 and uses thereof. Background technique [0002] Ganoderma (Ganoderma sp.) Belonging to Basidiomycetes (Basidiomycetes) polyporales (Polyporales) Polyporaceae (Polyporaceae) Ganoderma (of Ganoderma), is an important medicinal fungi, are widely used in traditional Chinese medicine, it pharmacological effects many expositions. "Shen Nong's Herbal Classic" records Ganoderma has vital essence, tonic, longevity and other effects of modern pharmacology and clinical trials further demonstrated Ganoderma lucidum has anti-aging, anti-viral, anti-oxidation, anti-tumor, enhance immunity, liver and so on . Ganoderma lucidum is one in which only two were included in the "People's Republic of China Pharmacopoeia." "People's Republic of China Pharmacopoeia" (2015 edition a) defined criteria: Moisture not more than 17.0%, total ash not more than 3.2%, extract of not less...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/14C08B37/00A23L31/00A23L33/125A61K31/715A61K36/074A61P35/00A61P37/04C12R1/645
CPCC08B37/0003A23L31/00A23L33/125A61K31/715A61K36/074A61P35/00A61P37/04A23V2002/00A23V2200/30A23V2200/324A23V2200/308A23V2250/51Y02A50/30
Inventor 罗霞余梦瑶贺黎铭李芳罗舒宋怡
Owner SICHUAN ACAD OF CHINESE MEDICINE SCI
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