Forming process method for high-strength functional PCL/HA porous bone scaffold

Abstract

The invention provides a forming process method for a high-strength functional PCL / HA porous bone scaffold. According to the forming process method, personalized manufacturing of the bone scaffold is realized by utilizing a 3DP process based on PCL / HA composite powder, and secondary curing of the bone scaffold is realized by utilizing secondary heating in combination with the characteristic of low melting point of PCL, so that the mechanical property of the scaffold is further improved; a high-energy post-treatment process is avoided while the strength of the scaffold is ensured so that functional substances can be synchronously compounded along with scaffold forming, and the functions of the scaffold are not influenced; by using the composite powder, the formed scaffold has high biological activity and high hardness endowed by HA, is beneficial to adhesion and proliferation of cells, and has high toughness and biodegradation characteristics endowed by PCL, so that stable transition between scaffold degradation and new bone formation is ensured, bone stability in the whole repair process is maintained, and enough redundancy is reserved for internal high porosity design; and in addition, the functional substances can be uniformly distributed on the whole scaffold instead of the surface of the scaffold, so that the prepared scaffold has better functions and bone repair and reconstruction effects.

Description

technical field [0001] The invention relates to the field of large-segment bone defect repair, in particular to a molding process method of a high-strength functional PCL / HA porous bone scaffold, belonging to the field of bone tissue engineering. Background technique [0002] Bone defects caused by trauma, tumors, etc. have always been the focus and difficulty of treatment. In clinical practice, autologous, allogeneic or xenogeneic bone grafts are usually used for repair. However, the source of autologous bone is insufficient, and there are many postoperative complications; the ability of allogeneic bone to combine with the host bone is weak, and it has antigenic properties, which may cause implantation failure due to severe immune rejection, and there is a possibility of disease transmission, and its clinical application is limited. . The development of bone tissue engineering provides a new solution, the core of which is to establish a space complex composed of cells / acti...

AI Technical Summary

Problems solved by technology

But at the same time, the content of PCL has a great influence on the forming accuracy of the stent. Excessive PCL will lead to serious shrinkage and deformation of the stent. If it is too small, the strength of the stent will be insufficient, and the performance improvement will not be obvious.

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