Dentin desensitization paste with bionic remineralization repair effect, and preparation process thereof

A technology of repairing and desensitizing paste, which is applied in the field of oral hygiene products, can solve the problems of incomplete closure of dentin tubules and easy dissociation of nano-hydroxyapatite particles, so as to alleviate the phenomenon of incomplete closure, improve the repair effect, strong adsorption effect

Pending Publication Date: 2021-08-27
陕西恒远生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, under the washing effect of saliva and deionized water, the nano-hydroxyapatite particles are easy to dissociate, resulting in incomplete closure of the dentinal tubules

Method used

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  • Dentin desensitization paste with bionic remineralization repair effect, and preparation process thereof
  • Dentin desensitization paste with bionic remineralization repair effect, and preparation process thereof
  • Dentin desensitization paste with bionic remineralization repair effect, and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] This embodiment provides a dentin desensitization paste with biomimetic remineralization repairing effect, in terms of mass percentage, comprising:

[0059] Silica 113 14.2%, glycerin 7.0%, polyethylene glycol 600 6.0%, xanthan gum 0.3%, sodium carboxymethylcellulose 0.6%, sorbitol 31.0%, potassium nitrate 4.0%, carboxy-modified dendritic Polyamidoamine 0.1%, 60nm Hydroxyapatite 2.0%, Isomaltooligosaccharide 1.0%, Xylitol 5.0%, Sodium Lauryl Sulfate 2.5%, Sodium Benzoate 0.2%, Titanium Dioxide 0.3%, Fragrance 0.8%, The balance is purified water.

[0060] The preparation process mainly includes the following steps:

[0061] 1) Dispersing xanthan gum and sodium carboxymethyl cellulose in glycerin, fully stirring to disperse it evenly, to obtain colloid A;

[0062] 2) Dissolving polyethylene glycol 600, sorbitol, potassium nitrate, isomaltooligosaccharide, xylitol, sodium benzoate, and carboxyl-modified dendritic polyamide-amine in purified water, and stirring until the ...

Embodiment 2

[0067] This embodiment provides a dentin desensitization paste with biomimetic remineralization repairing effect, in terms of mass percentage, comprising:

[0068] Silicon dioxide 113 12.2%, glycerin 6.0%, polyethylene glycol 600 6.0%, xanthan gum 0.3%, sodium carboxymethyl cellulose 0.6%, sorbitol 30.0%, potassium nitrate 4.0%, carboxyl modified dendrimer Amide-amine 0.1%, 60nm hydroxyapatite 5.0%, isomalto-oligosaccharide 1.0%, xylitol 5.0%, sodium lauryl sulfate 2.5%, sodium benzoate 0.2%, titanium dioxide 0.3%, essence 0.8%, excess The amount is purified water.

[0069] The preparation process mainly includes the following steps:

[0070] 1) Dispersing xanthan gum and sodium carboxymethyl cellulose in glycerin, fully stirring to disperse it evenly, to obtain colloid A;

[0071] 2) Dissolving polyethylene glycol 600, sorbitol, potassium nitrate, isomaltooligosaccharide, xylitol, sodium benzoate, and carboxyl-modified dendritic polyamide-amine in purified water, and stirri...

Embodiment 3

[0076] The present embodiment provides a dentin desensitization paste with biomimetic remineralization repairing effect, in terms of mass percentage, comprising:

[0077] Silica 113 9.0%, Glycerin 6.0%, Polyethylene Glycol 600 6.0%, Xanthan Gum 0.3%, Sodium Carboxymethyl Cellulose 0.6%, Sorbitol 28.2%, Potassium Nitrate 4.0%, Carboxyl Modified Dendritic Polyamidoamine 0.1%, 60nm Hydroxyapatite 8.0%, Isomaltooligosaccharide 1.0%, Xylitol 5.0%, Sodium Lauryl Sulfate 2.5%, Sodium Benzoate 0.2%, Titanium Dioxide 0.3%, Fragrance 0.8%, The balance is purified water.

[0078] The preparation process mainly includes the following steps:

[0079] 1) Dispersing xanthan gum and sodium carboxymethyl cellulose in glycerin, fully stirring to disperse it evenly, to obtain colloid A;

[0080]2) Dissolving polyethylene glycol 600, sorbitol, potassium nitrate, isomaltooligosaccharide, xylitol, sodium benzoate, and carboxyl-modified dendritic polyamide-amine in purified water, and stirring unt...

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Abstract

The invention provides a dentin desensitization paste with a bionic remineralization repair effect, and a preparation process thereof. The dentin desensitization paste comprises dendritic polyamide-amine and nano-hydroxyapatite, or a compound of the dendritic polyamide-amine and the nano-hydroxyapatite, water and auxiliary materials. The product can effectively block dentinal tubules, promote remineralization of dentin surfaces, repair demineralized dentin, treat hemodia symptoms and relieve the phenomenon of incomplete dentinal tubule sealing caused by saliva or deionized water flushing.

Description

technical field [0001] The invention belongs to the technical field of oral hygiene products, and in particular relates to a dentin desensitization paste with bionic remineralization repairing effect and a preparation process thereof. Background technique [0002] Dentin hypersensitivity refers to short-term, sharp discomfort or pain caused by mechanical, chemical, temperature, and osmotic stimulation of exposed dentin. The mechanism of dentin hypersensitivity is still in the theoretical state, and the current theory of hydrodynamics and nerve conduction is more consistent with clinical practice and accepted by most people. Based on this principle, most of the desensitizing materials currently used clinically exert anti-sensitizing effects by physically blocking and reducing nerve conduction. Occlusive desensitization materials mainly include inorganic filler type (such as fluoride, strontium salt), remineralization type (such as bioactive glass, casein phosphopeptide-amorp...

Claims

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Application Information

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IPC IPC(8): A61K6/54A61K6/60A61K6/69A61K6/75A61K6/838A61K6/891
CPCA61K6/54A61K6/75A61K6/891A61K6/838A61K6/60A61K6/69C08L79/08
Inventor 刘晓周斌李相文
Owner 陕西恒远生物科技有限公司
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