Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Construction and evaluation method of nano drug delivery system based on silica aerogel

A silicon aerogel, nano-drug loading technology, applied in nano-drug, nano-technology, nano-technology and other directions, to achieve the effect of good recovery, good specificity and high precision

Pending Publication Date: 2021-08-27
HARBIN UNIV OF COMMERCE
View PDF12 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The loaded target drugs are especially suitable for drugs that cannot penetrate the blood-brain barrier due to reasons such as strong water solubility, but the patent does not involve the solubility and release rate of insoluble drugs.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Construction and evaluation method of nano drug delivery system based on silica aerogel
  • Construction and evaluation method of nano drug delivery system based on silica aerogel
  • Construction and evaluation method of nano drug delivery system based on silica aerogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] A method for constructing a nanometer drug-carrying system based on silica airgel, comprising the following steps:

[0081] (1) Select insoluble drugs, and choose hydrophilic silica airgel as the carrier to carry insoluble drugs;

[0082] (2) The centrifugal impregnation method is used for drug loading, and the silicon airgel carrier is added after dissolving the drug powder in an organic solvent, and the ratio of the drug to the silicon airgel carrier is 4:1;

[0083] (3) Set drug loading parameters, mix under stirring conditions for drug loading, centrifuge at 5000r / min for 5min after drug loading, separate the precipitate, and dry the precipitate under reduced pressure to obtain sample powder.

[0084] The further optimized technical solution of this embodiment is that the hydrophilic silica airgel material is silica airgel.

[0085] The further optimized technical solution of this embodiment is that the poorly soluble drugs include BCS class II drugs. In this exam...

Embodiment 2

[0174] A kind of method for evaluating the silica airgel nano drug-carrying system that above-mentioned embodiment 1 builds, used test instrument and test material are as follows:

[0175] The experimental materials are as follows:

[0176]

[0177]

[0178] The experimental equipment is as follows:

[0179]

[0180] Specific evaluation methods for the constructed silica airgel nano-drug loading system, including morphology analysis of silica airgel, phase analysis of silica airgel, specific surface area and pore size analysis of silica airgel, silica airgel At least one of FT-IR spectroscopic analysis, thermal stability analysis of silicon aerogel, in vitro drug release determination, and gastrointestinal stability test.

[0181] The further optimized technical solution of this embodiment is that the morphology analysis of the silica airgel includes SEM analysis and TEM analysis.

[0182] Scanning electron microscopy can observe the shape characteristics and particle...

Embodiment 3

[0212] The construction and evaluation of a nano-drug loading system based on silica airgel is similar to Example 1, except that the insoluble drugs selected in step (1) are nifedipine, olanzapine, triamcinolone, naphthalene Any one of proxen, nevirapine, oxaprozin, phenazopyridine, and phenytoin.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
pore sizeaaaaaaaaaa
Login to View More

Abstract

The invention provides a construction and evaluation method of a nano drug loading system based on silica aerogel, and particularly relates to a method for preparing the drug silica aerogel nano drug loading system by taking two BCS II drugs (nimodipine and resveratrol) as indissolvable representative drugs, taking silica aerogel in the silica aerogel as a carrier and taking a centrifugal impregnation method as a drug loading method. The process for determining the optimal prescription comprises the following steps: dissolving medicine powder with absolute ethyl alcohol by adopting a centrifugal impregnation method, preparing a medicine ethanol solution with a certain concentration, weighing a proper amount of silica aerogel, adding the silica aerogel into an NMD ethanol solution, setting the medicine carrying temperature to be 25 DEG C, stirring at a medium speed for 24 hours, centrifuging for 5 minutes at the speed of 5000r / min, separating precipitates, and drying the precipitates under reduced pressure to obtain sample powder. Through test detection, the prepared silica aerogel nano drug loading system is obviously improved in the aspects of solubility and release rate of indissolvable drugs.

Description

technical field [0001] The invention relates to the technical field of chemical pharmacy, in particular to a method for constructing and evaluating a silicon airgel-based nanometer drug-carrying system. Background technique [0002] Oral administration is currently the preferred method of administration due to its advantages of safety, low cost, and strong patient compliance. With the application of various technologies in drug development, more and more candidate compounds have been designed, synthesized, and discovered, and a large number of active compounds have become candidate new drugs. However, statistics show that about 80% of candidate new drugs are insoluble in water, and about 40% of drugs on the market are also insoluble in water. Biopharmaceuticals (Biopharmaceutics Classification System, BCS) is divided into four categories according to the drug solubility and permeability, BCS class I with high solubility and high permeability; BCS class II with low solubilit...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/04A61K31/4422A61K31/05B82Y5/00B82Y40/00G01N5/00G01N21/33G01N21/3563G01N23/04G01N23/207G01N23/2251
CPCA61K47/02A61K31/4422A61K31/05B82Y5/00B82Y40/00G01N5/00G01N21/33G01N21/3563G01N23/04G01N23/207G01N23/2251
Inventor 吕春艳张文君
Owner HARBIN UNIV OF COMMERCE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com