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A kind of porous polyetheretherketone-hydroxyapatite composite material and its preparation method and application

A technology of hydroxyapatite and hydroxyapatite powder, which is applied in the fields of medical science, prosthesis, tissue regeneration, etc., can solve the problem of increasing osseointegration, reducing the mechanical properties of composite materials, and insufficient ability to induce osteoblast differentiation), etc. problem, to achieve the effect of improving biological activity and high biological activity

Active Publication Date: 2022-05-17
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent application CN110152068A discloses a polyether ether ketone / nano-hydroxyapatite composite material and its preparation method. The patent application uses a compound modification process of ball mill premixing combined with twin-screw extrusion to make the nano-hydroxyapatite uniform Dispersed in polyetheretherketone, which solves the technical problem of stress concentration caused by the agglomeration effect of nano-hydroxyapatite and ultimately leads to the reduction of the mechanical properties of the composite material, and further improves the bioactivity of polyetheretherketone / nano-hydroxy Mechanical properties of apatite composites
However, this method can only increase the specific surface area of ​​the PEEK material, thereby increasing the osseointegration of the material, and PEEK is a biologically inert material. The PEEK material treated by this method has the problem of insufficient osteoinduction (osteoblast differentiation) ability.
[0007] Although the current methods for improving the osseointegration (biological activity) of PEEK are mainly surface treatment (surface porous / completely porous) or adding biological particles, there is no combination of biological particles and penetrating porous structures in the prior art. Related reports of PEEK composite materials

Method used

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  • A kind of porous polyetheretherketone-hydroxyapatite composite material and its preparation method and application
  • A kind of porous polyetheretherketone-hydroxyapatite composite material and its preparation method and application
  • A kind of porous polyetheretherketone-hydroxyapatite composite material and its preparation method and application

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preparation example Construction

[0036] In a first aspect, the present invention provides a method for preparing a porous polyether ether ketone-hydroxyapatite composite material, for example, as figure 1 As shown, the method includes the following steps:

[0037] S1, powder filling (also referred to as powder filling): uniformly disperse polyetheretherketone powder (PEEK powder) and hydroxyapatite powder (HA powder), such as using a planetary ball mill to obtain a mixed powder (also referred to as PEEK powder) -HA powder); then the mixed powder (the melting point of the mixed powder is about 340°C) is filled into foamed aluminum and vibrated by a vibrator so that the mixed powder is filled in the pores of the foamed aluminum, Composite aluminum foam is obtained; in the present invention, the polyetheretherketone powder is preferably polyetheretherketone powder with an average particle diameter of 50-100 μm, and the hydroxyapatite powder is preferably polyether ether ketone powder with an average particle dia...

Embodiment 1

[0054] A new powder filling-hot pressing-alkali cleaning method was used to prepare P-PEEK-HA composite materials. The preparation process was as follows: figure 1 As shown, the specific process is as follows.

[0055] (1) Powder filling (powder filling): PEEK powder (average particle size: 75 μm; glass transition temperature (T g ): 153.40°C; melting temperature (T m): 347.55°C) and HA powder (average particle size: 20nm, purity ≥ 99.0%). The PEEK powder and HA powder are uniformly dispersed by a planetary ball mill (the model YXQM produced by Miter Instrument Equipment Co., Ltd. in Changsha, China) to obtain a uniform mixed powder. The mass of the HA powder contained in the mixed powder is The percentage content is 20wt%; when the polyether ether ketone powder and the hydroxyapatite powder are uniformly dispersed by a planetary ball mill, the weight ratio of the ball powder is set to 3:1, the rotating speed is set to 250 rpm, and the forward rotation time is set to 10 min...

Embodiment 2

[0072] Embodiment 2 is basically the same as Embodiment 1, the difference is:

[0073] Step (2) hot pressing is: place the composite foamed aluminum in a hot pressing mold and then put it into a hot press with a set temperature and pressure program to carry out the hot pressing; the hot pressing includes a heating stage, heat preservation stage, stage and cooling stage: the target temperature for heating in the heating stage is 380°C, and the hot pressing pressure applied in the heating stage is 2MPa; in the holding stage, the holding temperature is 380°C, the holding pressure is 2MPa, and the holding time is 50min; In the second stage, the pressure is maintained and the temperature is lowered. The pressure is 2MPa, the cooling rate is 1.5°C / min, and the temperature is lowered to room temperature (25°C).

[0074] During the hot pressing process of this embodiment, the aluminum foam was crushed and destroyed, and the melted PEEK-HA powder could not be filled into the pores of t...

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Abstract

The invention relates to a porous polyetheretherketone-hydroxyapatite composite material and its preparation method and application. The method is as follows: uniformly disperse polyether ether ketone powder and hydroxyapatite powder to obtain a mixed powder; then fill the mixed powder into foamed aluminum and vibrate with a vibrator so that the mixed powder is filled in the In the pores of the above-mentioned foamed aluminum, composite foamed aluminum is obtained; the composite foamed aluminum is placed in a hot-pressing mold and hot-pressed to obtain polyetheretherketone-hydroxyapatite-foamed aluminum composite material; the polyether ether The ketone-hydroxyapatite-aluminum foam composite material is cut and alkaline-cleaned with an alkaline solution to remove the aluminum foam to obtain a porous polyether ether ketone-hydroxyapatite composite material. The pores (continuously running through the porous structure) and HA in the porous polyether ether ketone-hydroxyapatite composite material prepared by the method of the present invention provide a connected network structure and biological activities of bone cell growth and body fluid transfer.

Description

technical field [0001] The invention belongs to the technical field of biological material preparation, and in particular relates to a porous polyether ether ketone-hydroxyapatite composite material and a preparation method and application thereof. Background technique [0002] As an emerging thermoplastic engineering material, polyetheretherketone (PEEK) has many excellent properties, such as elastic modulus relatively close to that of cortical bone, high temperature resistance, chemical stability, and chemical corrosion resistance. These properties are of great interest for a wide range of applications as a material for fixed and removable partial dentures, as well as for orthopedic implants, intervertebral fusions, and cranioplasty. [0003] However, due to its stable chemical structure and relatively low surface energy, PEEK has a hydrophobic surface, which makes its osseointegration and bioactivity poor. This shows that PEEK-based biomedical composites are facing great...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/46A61L27/56
CPCA61L27/46A61L27/56A61L2430/02C08L61/16
Inventor 王兵李帅李高胡记强王连超陈锐周振功
Owner HARBIN INST OF TECH