Method for preparing water-soluble nanogold

A nano-gold, water-soluble technology, applied in nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problems of impurity and inhomogeneity of nano-gold particles, and achieve easy implementation, high purity, The effect of high industrial application value

Pending Publication Date: 2021-09-07
NANJING UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the problems that the existing preparation methods need to use environmentally unfriendly organic solvents, strict operating conditions, and inhomogeneous and impure nano-gold particles, the purpose of the present invention is to provide a method for preparing water-soluble nano-gold, which has green , high efficiency, mild, controllable, high purity and stability, etc.

Method used

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  • Method for preparing water-soluble nanogold
  • Method for preparing water-soluble nanogold
  • Method for preparing water-soluble nanogold

Examples

Experimental program
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Effect test

Embodiment 1

[0046] Embodiment 1 dark reaction prepares water-soluble nano gold

[0047] Chlorauric acid (HAuCl 4 4H 2 (O) and the molar ratio of AA are set at 1:10, get 0.0625mL of chloroauric acid stock solution, 1.5mL of 5mMAA solution of 12mM, add volume and be in the glass colorimetric tube of 25mL, add ultrapure water and be diluted to the scale place, Oscillate evenly, that is, 0.03mM chloroauric acid, 0.3mMAA. Then wrap the colorimetric tube with tinfoil to ensure a dark environment, and place it for a period of time to obtain a uniform purple-red simple gold colloid mixture.

[0048] figure 1 It is the transmission electron microscope (TEM, JEOL, JEM-100S, Japan) images of the purple-red gold nanoparticles prepared in this example at different time points. It can be found that the AA system can be prepared by placing the AA system for 10 minutes in the absence of light. As the storage time increases, the particle size of the nano-gold gradually becomes larger, and the irregula...

Embodiment 2

[0049] Embodiment 2 photochemical reaction prepares water-soluble nano gold

[0050] Set the molar ratio of chloroauric acid and AA (or BD, BP, I-2959) at 1:3.3, take 0.625mL of 12mM chloroauric acid, 5mL of 5mMAA (or BD, BP, I-2959) solution, add In a glass colorimetric tube with a volume of 25mL, add ultrapure water to dilute to the mark, shake evenly, that is, 0.3mM chloroauric acid, 1.0mM AA or BD, BP, I-2959.

[0051] Then pour into a 25mL quartz photoreaction tube, and finally put the reaction tubes into the photoreactor one by one. Use a medium pressure mercury lamp with a light intensity of 7.5mW / cm 2 , respectively illuminate the corresponding AA solution for 4 minutes, and the solutions of BD, BP, and I-2959 for 30 minutes to prepare a mixture of simple gold colloids.

[0052] Centrifuge (10000~15000rpm, centrifuge 10~30min) after purplish red colloid mixed liquid, remove supernatant, add ultrapure water to wash and then centrifuge again, after so repeating three t...

Embodiment 3

[0059] The stability of the gold nanometer prepared by embodiment 3 UV / diketone method

[0060] The molar ratio of chloroauric acid and AA (or BD) is set at 1:2, and each 0.208mL and 1mL of 12mM chloroauric acid and 5mM AA (or BD) are added into a glass colorimetric tube with a volume of 25mL. Add ultrapure water to dilute to the mark, shake evenly, that is, a mixed solution of 0.1mM chloroauric acid and 0.2mMAA (or BD). The pH of the solution was adjusted to 3.3 with 0.1M perchloric acid and sodium hydroxide. Then pour into a 25mL quartz photoreaction tube, and finally put the reaction tubes into the photoreactor successively. Use a low-pressure mercury lamp to illuminate for 30 minutes, and the light intensity of the reaction is 1.4mW / cm 2 , the prepared nano-gold colloidal mixture was placed in a refrigerator at 4°C for storage. The UV-Vis spectrum of the solution was detected at regular intervals.

[0061] Figure 5 It is the change figure of the absorbance of the LSP...

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Abstract

The invention discloses a method for preparing water-soluble nanogold. The method comprises the following steps of: mixing a solution containing chloroauric acid radical ions with micromoleculardiketone to obtain a mixed solution, and standing to obtain a water-soluble nanogold solution. The solution containing the chloroauric acid radical ions comprises a sodium chloroauric acid solution, a potassium chloroauric acid solution or a chloroauric acid tetrahydrate solution and the like, and the micromolecular diketone comprises 2, 3-butanedione, 2, 3-pentanedione, 2, 4-pentanedione, 2, 5-hexanedione and the like. According to the method, homogeneous reaction is adopted, no surfactant or the like needs to be added, operation is easy and convenient, and energy consumption is low. The particle size range of the obtained nanogold is 15-45 nm, and the obtained nanogold is in the form of well-dispersed nanospherical and triangular particles. The nanogold has tunable localized surface plasma resonance (LSPR) and ultrahigh stability and has a good application prospect in the fields of biomedicine and electrodes such as plasmon biosensors.

Description

technical field [0001] The invention relates to the field of nanometer materials, in particular to a method for preparing water-soluble nanometer gold. Background technique [0002] In recent years, gold nanoparticles (Au NPs, nanogold) have been widely used in the fields of materials science, biotechnology, and organic chemistry due to their functions as molecular markers, diagnostic imaging, and catalysis (“Anisotropic gold nanoparticles: A survey of recent synthetic methodologies [J ].” Jose E. Ortiz-Castillo, Roberto C. Gallo-Villanueva, Marc J. Madou, et al, Coord. Chem. Rev., 2020, 425, 213489). The size of gold nanoparticles has an important impact on its application. At present, the preparation and size control technologies of gold nanomaterials include the following two types: 1) physical methods, such as pulsed laser ablation, arc discharge, high energy consumption, and expensive equipment. Not suitable for popularization and application; 2) chemical methods, such...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B22F9/24B22F1/00B82Y30/00B82Y40/00
CPCB22F9/24B82Y40/00B82Y30/00B22F2202/11
Inventor 张淑娟张丽甘永海吴兵党陈志豪韦霜霜
Owner NANJING UNIV
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