Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Pathological specimen sealing liquid and preparation and sealing methods thereof

A technique for specimens and pathology, which is applied in the field of pathological specimens’ mounting liquid and its preparation and sealing, can solve the problems that affect the needs of follow-up visits or scientific research, cannot meet the needs of use, and affect the health of operators, etc., to achieve the benefits of automated production, Improve the sealing efficiency and good environmental protection effect

Pending Publication Date: 2021-09-17
刘济忠
View PDF16 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the sealing machine has greatly improved the work efficiency and made the slice quality more standardized and standardized, the cost of sealing the film is high and the consumption is fast. At the same time, the solvent xylene should be used when sealing the film. Xylene is poisonous and has a pungent smell. Use can affect the health of the operator
In addition, in clinical practice, the specimens sealed with film will fade after a few years, which will affect the needs of follow-up visits or scientific research, and can no longer meet the needs of medical use.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pathological specimen sealing liquid and preparation and sealing methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] 1) Use 45 parts of polyester acrylic resin, 5 parts of isobornyl methacrylate, 20 parts of 1,6-hexanediol diacrylate, 15 parts of tripropylene glycol diacrylate, 10 parts of dipentaerythritol hexaacrylate, 1- 2 parts of hydroxycyclohexyl phenyl ketone, 2 parts of 2,4,6-trimethylbenzoyl-diphenylphosphine oxide, 0.5 part of leveling agent BYK333, 0.5 part of defoamer TEGO920, 1 part of coupling agent KH550 and 0.5 part of antioxidant 6026 were used to prepare pathological specimen mounting solution.

[0033] 2) Place the pre-treated specimen slide in a horizontal position, then coat the pathological specimen mounting solution, level it quickly, and irradiate with ultraviolet light to obtain the pathological specimen mounting liquid-sealed glass slide.

[0034] 3) Obtained pathological specimen mounting fluid sealing coating is smooth and flat, and the overall light transmittance is above 90%. Use a pencil hardness tester to test the hardness of the coating, a Chinese dra...

Embodiment 2

[0036] 1) Use 50 parts of polyurethane acrylic resin, 5 parts of isobornyl acrylate, 15 parts of tripropylene glycol diacrylate, 10 parts of trimethylolpropane triacrylate, 10 parts of pentaerythritol triacrylate, 2-hydroxy-2-methyl - 3 parts of 1-phenylacetone, 1 part of phenylbis(2,4,6-trimethylbenzoyl) phosphine oxide, 0.5 part of leveling agent BYK333, 0.5 part of defoamer TEGO920, 1 part of coupling agent KH560, 0.5 part of antioxidant 1010 to prepare pathological specimen mounting solution.

[0037] 2) Place the pre-treated specimen slide in a horizontal position, then coat the pathological specimen mounting solution, level it quickly, and irradiate with ultraviolet light to obtain the pathological specimen mounting liquid-sealed glass slide.

[0038] 3) Obtained pathological specimen mounting fluid sealing coating is smooth and flat, and the overall light transmittance is above 90%. Use a pencil hardness tester to test the hardness of the coating, a Chinese drawing pen...

Embodiment 3

[0040] 1) Use 55 parts of epoxy-modified acrylic resin, 8 parts of hydroxyethyl methacrylate, 10 parts of neopentyl glycol diacrylate, 12 parts of trimethylolpropane triacrylate, 10 parts of dipentaerythritol hexaacrylate, 3 parts of 2-methyl-2-(4-morpholinyl)-1-[4-(methylthio)phenyl]-1-propanone, 2 parts of 2-isopropylthioxanthone, 0.4 parts The pathological specimen mounting solution was prepared by leveling agent TEGO2100, 0.3 part of defoamer KS66, 1 part of coupling agent KH570, and 0.5 part of antioxidant 6026.

[0041] 2) Place the pre-treated specimen slide in a horizontal position, then coat the pathological specimen mounting solution, level it quickly, and irradiate with ultraviolet light to obtain the pathological specimen mounting liquid-sealed glass slide.

[0042] 3) The obtained pathological specimen mounting liquid sealing coating is smooth and flat, and the overall light transmittance is above 91%. Use a pencil hardness tester to test the hardness of the coat...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
wavelengthaaaaaaaaaa
Login to View More

Abstract

The invention discloses a pathological specimen sealing liquid and a preparation method and a sealing method thereof. The pathological specimen sealing liquid is prepared from the following raw materials: an oligomer, an active monomer, an initiator, a flatting agent, a de-foaming agent, a coupling agent and an antioxidant, the preparation method of the pathological specimen sealing liquid comprises the following steps: S1, weighing various raw materials according to the parts; S2, sequentially adding various raw materials into a container to obtain a mixed solution; S3, keeping the temperature in the container at 40-55 DEG C, and carrying out stirring; and S4, filtering the mixed solution by using a filter screen, then carrying out air extraction and defoaming treatment on the filtrate by using a vacuum air pump, and standing and cooling the filtrate. The sealing method of the pathological specimen sealing liquid comprises the following steps: step 1, placing a treated specimen glass slide at a horizontal position, and then coating the pathological specimen sealing liquid on the surface of the glass slide; and 2, after the pathological specimen sealing liquid is leveled on the surface of the glass slide, irradiating the pathological specimen sealing liquid by using ultraviolet light.

Description

technical field [0001] The invention relates to the field of experimental equipment, in particular to a pathological specimen mounting solution and a preparation and sealing method thereof. Background technique [0002] At present, the common form of specimens is glass slide-adhesive-cover glass, and there are two methods of production: manual and machine. [0003] The manual method has the following disadvantages: the cover glass is very thin, and it is easy to cut and leave fingerprints if it is held by hand, which will affect the observation under the microscope; if it is clamped with tweezers, it is easy to be cracked or broken; Operators have high requirements, and they must control the amount of adhesive (glue) required for each sheet to prevent glue leakage and overflow; and there are requirements for operating techniques to avoid the generation of air bubbles; in addition, it is necessary to control the strength of the cover pressure, Do not damage the sample and af...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/30G01N1/28A01N1/02
CPCG01N1/30G01N1/28A01N1/0231G01N2001/305
Inventor 刘济忠
Owner 刘济忠
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com