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A nitrogen-rich porous polymer biocompatible solid-phase microextraction probe and its application

A porous polymer and biocompatibility technology, applied in other chemical processes, preparation of test samples, solid adsorbent liquid separation, etc., can solve the problems of limited SPME application in vivo, unsatisfactory broad-spectrum extraction performance, and biocompatibility Poor compatibility and other problems, to achieve the effect of short extraction time, good biocompatibility and heat resistance, and low detection limit

Active Publication Date: 2022-04-01
INSTITUTE OF ANALYSIS GUANGDONG ACADEMY OF SCIENCES (CHINA NATIONAL ANALYTICAL CENTER GUANGZHOU)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although some coatings have been commercialized, these commercial probes have disadvantages such as high price (800-900 yuan a piece), unsatisfactory broad-spectrum extraction performance, and poor biocompatibility, which limit the application of in vivo SPME sampling technology.

Method used

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  • A nitrogen-rich porous polymer biocompatible solid-phase microextraction probe and its application
  • A nitrogen-rich porous polymer biocompatible solid-phase microextraction probe and its application
  • A nitrogen-rich porous polymer biocompatible solid-phase microextraction probe and its application

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Embodiment 1

[0023] Example 1: Preparation of nitrogen-rich porous polymer biocompatible solid-phase microextraction probe

[0024] 1. Preparation of nitrogen-rich porous polymer

[0025] (1) Preparation of p-phenylene di(melamine) (abbreviated as p-BzDAT monomer):

[0026]

[0027] Potassium hydroxide (1.68g, 30mmol), dicyandiamide (7.57g, 90mmol), and terephthalonitrile (2.56g, 20mmol) were added in 30mL of ethylene glycol methyl ether solvent respectively, and heated to React at 130°C for 48 hours, cool to room temperature after the reaction, collect the precipitate by filtration, wash the precipitate with hot water and ethanol respectively, and put the product in a vacuum drying oven at 80°C to dry for 20 hours to obtain a white powder of p-BzDAT monomer .

[0028] (2) Preparation of nitrogen-rich porous polymer:

[0029] Add p-BzDAT monomer and formamide into dimethyl sulfoxide (DMSO) solvent, heat the reaction under the protection of nitrogen atmosphere, the reaction temperatur...

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Abstract

The invention discloses a nitrogen-rich porous polymer biocompatible solid-phase microextraction probe and its application in the analysis of pesticide residues in living plants and the analysis of endogenous non-target metabolites. The nitrogen-rich porous polymer A biocompatible solid-phase microextraction probe, comprising a stainless steel wire and a surface coating coated on the stainless steel wire, the surface coating is made of nitrogen-rich porous polymer and biocompatible polydimethylsiloxane The prepared nitrogen-rich porous polymer biocompatible solid-phase microextraction probe has a good extraction effect on pesticides and plant endogenous metabolites, and the coating has good biocompatibility and tolerance High temperature fully meets the application requirements of living body sampling and thermal desorption instrument analysis, and the extraction effect is better than that of expensive commercial solid-phase microextraction probes on the market.

Description

Technical field: [0001] The invention relates to the field of solid-phase microextraction and the field of analysis, in particular to a nitrogen-rich porous polymer biocompatible solid-phase microextraction probe and its application. Background technique: [0002] Pesticides used in agricultural production can enter plants directly through plant roots or leaves, affecting the normal physiological and metabolic processes of plants, and threatening ecology and human health along the food chain. Elimination and the metabolic imbalance behavior and mechanism of plants under the stress of pesticide pollution are of great significance for in-depth assessment of the biological risk of pesticide pollution. It is very important to develop a sample pretreatment method that can effectively extract pesticide residues and disturbed metabolites with different properties in plants, so as to avoid the loss of target substances and metabolites in the pretreatment process as much as possible....

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D15/10B01J20/285G01N1/28
CPCB01D15/10B01J20/285G01N1/28
Inventor 刘舒芹吴锐向章敏黄毅权
Owner INSTITUTE OF ANALYSIS GUANGDONG ACADEMY OF SCIENCES (CHINA NATIONAL ANALYTICAL CENTER GUANGZHOU)
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