Magnetic bioactive glass as well as preparation method and application thereof

A bioactive glass, magnetic technology, applied in glass manufacturing equipment, glass molding, manufacturing tools and other directions, can solve the problems of the need to improve biological activity, expensive raw materials, lower calcination temperature, etc., to reduce synthesis cost, low cost, The effect of reducing the composition time

Active Publication Date: 2021-09-24
ZHONGNAN HOSPITAL OF WUHAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Traditional bioactive glass is calcined at a temperature above 1300°C by calcining oxides such as calcium oxide, silicon dioxide, phosphorus pentoxide, and sodium oxide, but it requires high equipment and the production process is relatively dangerous.
The preparation method of the second-generation bioglass is the gel method, which is obtained by hydrolyzing tetraethyl orthosilicate, triethyl phosphate, calcium nitrate, etc. under acid or alkali catalyzed conditions, and then aging, drying, and calcination. This method can greatly reduce the calcination temperature, but the required raw materials are more expensive and the synthesis cycle is longer
And the bioactivity of the bioactive glass in the prior art all needs to be improved

Method used

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  • Magnetic bioactive glass as well as preparation method and application thereof
  • Magnetic bioactive glass as well as preparation method and application thereof
  • Magnetic bioactive glass as well as preparation method and application thereof

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Embodiment approach

[0054] According to a typical embodiment of the present invention, a method for preparing magnetic bioactive glass is provided, the method comprising:

[0055] Step S1, preparing sodium metasilicate pentahydrate into sodium silicate transparent colloid sodium silicate transparent colloid;

[0056] As an optional implementation manner, the step S1 includes:

[0057] Add sodium metasilicate pentahydrate into pure water, and then add concentrated sulfuric acid dropwise until all solids disappear to form sodium silicate transparent glue; the concentration of the concentrated sulfuric acid is usually 25-35%; in other embodiments, Concentrated sulfuric acid is replaced by hydrochloric acid;

[0058] Step S2, adding iron ferric oxide and magnesium oxide to the sodium silicate transparent colloid, then adding concentrated sulfuric acid dropwise until the pH is 7-8, reacting at 50-70°C for 20-40 hours, and filtering to obtain black solid;

[0059] In the step S2, the concentration r...

Embodiment 1

[0083] The embodiment of the present invention provides a magnetic bioactive glass, the preparation method of which is as follows:

[0084] Add 39g sodium metasilicate pentahydrate to 20mL purified water, add 30% concentrated sulfuric acid dropwise until all solids disappear and form a transparent colloid;

[0085] Add 5g of ferric oxide and 1g of magnesium oxide to the transparent colloid, continue to slowly add 30% concentrated sulfuric acid dropwise until it is neutral, then treat it at 60°C for 30h, filter, wash and filter with purified water for 3 times, and then Dry to constant weight at 105°C to obtain a black solid powder;

[0086] Weigh 20g of calcium nitrate tetrahydrate to prepare a saturated solution, add black solid powder to the saturated solution, heat-treat at 120°C for 15 hours, and then place it in a muffle furnace for high-temperature calcination. The heating curve is: 8°C / min from 30°C Raise the temperature to 150°C, keep it for 1 hour, then raise the temp...

Embodiment 2

[0088] The embodiment of the present invention provides a magnetic bioactive glass, the preparation method of which is as follows:

[0089] Add 40g sodium metasilicate pentahydrate to 20mL purified water, add 30% concentrated sulfuric acid dropwise until all solids disappear and form a transparent colloid;

[0090] Add 8g ferric oxide and 1g magnesium oxide to the transparent colloid, continue to slowly add 30% concentrated sulfuric acid dropwise until the pH is neutral, then treat at 70°C for 20h, filter, wash and filter with purified water 3 times, Then dry to constant weight at 110°C to obtain a black solid powder;

[0091] Weigh 20g of calcium nitrate tetrahydrate to prepare a saturated solution, add black solid powder to the saturated solution, heat-treat at 130°C for 12 hours, and then place it in a muffle furnace for high-temperature calcination. The heating curve is: 5°C / min from 30°C Raise the temperature to 160°C, keep it for 1 hour, then raise it to 500°C at 10°C / m...

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Abstract

The invention discloses magnetic bioactive glass as well as a preparation method and application thereof. The magnetic bioactive glass is obtained by carrying out high-temperature calcination on glass with a core-shell structure, the glass with the core-shell structure is of the core-shell structure which takes ferroferric oxide as a core layer and takes silicon dioxide and calcium oxide as a shell layer to be coated on the core layer, and after high-temperature calcination, the ferroferric oxide is oxidized into magnetic gamma-ferric oxide. The method comprises the steps of adding ferroferric oxide and magnesium oxide into sodium silicate transparent colloid, dropwise adding concentrated sulfuric acid until the pH value is 7-8, reacting at the temperature of 50-70 DEG C, filtering, cleaning, filtering and drying to obtain black solid powder; and adding into a calcium nitrate tetrahydrate saturated solution for heat treatment, and then calcining at high temperature to obtain the magnetic bioactive glass. The method is simple in process, low in cost and relatively low in calcination temperature, the surface of the material has a microporous structure, the specific surface area is larger, mineralization of the material is facilitated, and the biological activity of the material is improved.

Description

technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a magnetic bioactive glass and its preparation method and application. Background technique [0002] Bioactive glass was invented by Professor Hench. Due to its special composition and structure, after implanted into the human body, a series of special surface reactions will occur in the biological environment, forming a mineralized layer on the surface, which is conducive to the combination with surrounding tissues. It is precisely because of the above-mentioned characteristics of bioactive glass that it has good bioactivity and tissue repair ability, and has a wide range of clinical applications. Bone tumors have always been a difficult problem in the field of orthopedics. After removing the lesion and implanting bone repair materials, it is still easy to recur, which brings great pain to patients. However, the heat resistance of tumor cells is poor, and when the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C03C3/062C03C3/085C03C4/00C03B19/12A61L27/02A61L27/10A61L27/54A61L27/56
CPCC03C3/062C03C3/085C03C4/00C03C4/0007C03B19/12A61L27/10A61L27/025A61L27/54A61L27/56A61L2430/02A61L2300/102A61L2300/412
Inventor 蔡林闫飞飞张铁雷清剑张梦雪
Owner ZHONGNAN HOSPITAL OF WUHAN UNIV
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