A kind of method for preparing β-haloether and β-halohydrin catalyzed by peroxidase

A technology of peroxidase and peroxidase is applied in the biological field to achieve the effects of being beneficial to large-scale production, simple raw materials and mild reaction conditions
CN113549659BActive Publication Date: 2022-07-26TIANJIN INST OF IND BIOTECH CHINESE ACADEMY OF SCI
0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN INST OF IND BIOTECH CHINESE ACADEMY OF SCI
Publication Date
2022-07-26

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a method for preparing β-halogenated ether and β-halogenated alcohol catalyzed by peroxidase. It includes the following steps: adding hydrogen peroxide, halogen salt, and alkene shown in formula III in the buffer solution, and finally adding peroxidase, and reacting to obtain the β-halohydrin shown in formula I; when the above reaction system When also adding the alcohol shown in formula IV, the β-halogenated ether shown in formula II is obtained; in formula I, formula II, formula III, and formula IV, R 1 is alkyl, phenyl, substituted phenyl, aryl or substituted aryl; R 2 is hydrogen, alkyl, phenyl, substituted phenyl, aryl or substituted aryl; wherein, also includes R 1 and R 2 linked as cycloalkyl; R 3 is alkyl, phenyl, substituted phenyl, aryl, or substituted aryl. The raw material of the invention is simple and easy to obtain, the reaction conditions are mild, and the operation is simple and convenient.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to a method for preparing beta-haloether and beta-halohydrin catalyzed by peroxidase, and belongs to the field of biotechnology. Background technique

[0002] Halogenated ether compounds are widely used. Several general anesthetics commonly used in the market today, such as sevoflurane and isoflurane, contain halogenated ether structural units. For example, sevoflurane is one of the most widely used general anesthesia drugs, which has the advantages of low metabolic rate, low stimulation and rapid elimination. In 1981, Coon Clifford L et al. used 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as raw material, reacted with paraformaldehyde in excess hydrogen fluoride gas and oleum. Synthesis of sevoflurane. In this reaction, hydrogen fluoride is a poisonous gas with a pungent odor, which is expensive and causes environmental pollution, and oleum is a hazardous chemical, which has strong irritating and corrosive effects on human skin, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More