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A medical metal material with a modified film with photothermal properties on its surface, its preparation method and application

A metal material and modification technology, which is applied in metal material coating technology, pharmaceutical formula, medical science, etc., can solve the problems of non-precious metal nano-metal particles being easily oxidized, the cost of nano-nickel is reduced, and the photothermal effect cannot be maintained for a long time.

Active Publication Date: 2022-08-02
HEBEI UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Compared with traditional noble metal photothermal materials, the cost of nano-nickel constructed in the present invention is significantly reduced, and at the same time, it effectively solves the problem that non-noble metal nano-metal particles are easily oxidized and the photothermal effect cannot be maintained for a long time

Method used

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  • A medical metal material with a modified film with photothermal properties on its surface, its preparation method and application
  • A medical metal material with a modified film with photothermal properties on its surface, its preparation method and application
  • A medical metal material with a modified film with photothermal properties on its surface, its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A nickel-titanium (atomic ratio 1:1, purity 99.99%) alloy disk with a diameter of 10 mm and a thickness of 1 mm was cleaned with alcohol, deionized water and ultrasonic waves in sequence for 15 minutes each time. Using a solution containing 3mM nickel chloride, 1mM titanium chloride, and 6.5g / L urea (ie, 108mM) as the hydrothermal medium, the samples were hydrothermally treated under airtight conditions. The hydrothermal temperature was 120°C and the time was 24h. The filling degree of the hydrothermal kettle is 35%. After hydrothermal treatment, rinse with a large amount of deionized water until the pH of the cleaning solution drops to 7. After drying, the samples were placed in a mixed atmosphere of argon / hydrogen for heat treatment. The flow rate of argon gas was 20 sccm, the flow rate of hydrogen gas was 5 sccm, the heat treatment temperature was 450 °C, and the heat treatment time was 1 h.

[0040] figure 1 It is a scanning electron microscope picture of the sur...

Embodiment 2

[0043] A nickel-titanium alloy (nickel-titanium atomic ratio of 1:1, purity 99.99%) with a diameter of 10 mm and a thickness of 1 mm was cleaned with alcohol, deionized water and ultrasonic waves in sequence for 15 minutes each time. The sample was hydrothermally treated with a solution containing 3 mM nickel chloride, 1 mM titanium chloride, and 6.5 g / L urea (108 mM) as the hydrothermal medium. The hydrothermal temperature was 120 °C and the time was 24 h. The filling degree of the hydrothermal kettle is 35%. After hydrothermal treatment, rinse with a large amount of deionized water until the pH of the cleaning solution drops to 7. After drying, the samples were placed in argon for heat treatment, the flow rate of argon was 20 sccm, the heat treatment temperature was 450 °C, and the heat treatment time was 1 h.

Embodiment 3

[0045] A nickel-titanium alloy (nickel-titanium atomic ratio of 1:1, purity 99.99%) with a diameter of 10 mm and a thickness of 1 mm was cleaned with alcohol, deionized water and ultrasonic waves in sequence for 15 minutes each time. The sample was hydrothermally treated with a solution containing 6mM nickel chloride, 4mM titanium chloride and 6.5g / L urea (108Mm) as the hydrothermal medium. The hydrothermal temperature was 120°C and the time was 24h. The filling degree of the hydrothermal kettle is 35%. After hydrothermal treatment, rinse with a large amount of deionized water until the pH of the cleaning solution drops to 7. After drying, the samples were placed in a mixed atmosphere of argon / hydrogen for heat treatment. The flow rate of argon gas was 20 sccm, the flow rate of hydrogen gas was 5 sccm, the heat treatment temperature was 450 °C, and the heat treatment time was 1 h.

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Abstract

The invention relates to a medical metal material with a modified film with photothermal properties on the surface, a preparation method and application thereof. The modified film is nickel-titanium oxide Ti inlaid with nano-nickel m Ni n O 2m+n . The nano-nickel is a simple substance, the shape is spherical, and the radius is 2-20 nm; the density of the nickel nanoparticles is 5-30 per square micron. The nickel-titanium oxide has a sheet-like structure, the length and width of the sheet layer are between 0.5-2 μm, and the thickness is 10-40 nm. In the preparation method, the nickel-titanium layered double hydroxide is first generated, and then reduced by heating to obtain a nickel-titanium oxide thin film inlaid with elemental nickel. The cost of the nano-nickel constructed by the invention is obviously reduced, and at the same time, it effectively solves the problem that the non-precious metal nano-metal particles are easily oxidized and the photothermal effect cannot be maintained for a long time; it also has good osteogenic properties, improves the biological activity of medical metals, and is suitable for Surface modification of hard tissue implant devices.

Description

technical field [0001] The invention relates to a medical metal surface modified film and a preparation method and application thereof, in particular to a functional film with photothermal effect and osteogenesis effect obtained by hydrothermal reaction and thermal reduction successively obtained from medical metal as substrate The invention belongs to the technical field of surface modification of metal materials. Background technique [0002] Zinc, magnesium, iron, titanium and alloys of the above metals are widely used as hard tissue replacement materials due to their good mechanical properties and biocompatibility. Many current implant scenarios require materials with anticancer properties. For example, in patients with bone cancer, after the affected area is replaced by an implant, the cancer may still recur, but if the implant itself has the ability to fight tumors, the possibility of recurrence will be reduced. In view of the sensitivity of tumor tissue to heat, pho...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/06A61L27/54A61L31/02A61L31/16C23C26/00
CPCA61L27/06A61L27/54A61L31/022A61L31/16C23C26/00A61L2400/18
Inventor 王东辉郝雪青李宝娥梁春永
Owner HEBEI UNIV OF TECH
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