High-fat feed for inducing obesity and non-alcoholic fatty liver model and production process of high-fat feed

A non-alcoholic, high-fat feed technology, applied in the molding or processing of animal feed, animal feed, application, etc., can solve the problem of not being able to simulate the occurrence of obesity, lack and other problems, and achieve low cost, high repetition rate, Characterize a significant effect

Pending Publication Date: 2022-03-18
HUNAN AGRICULTURAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the above models can effectively establish the representation of obesity, they cannot simulate the actual occurrence of obesity well.
High-fat and high-energy diets are the root of the obesity epidemic, and there is currently a lack of high-fat diets for inducing obesity and non-alcoholic fatty liver models

Method used

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  • High-fat feed for inducing obesity and non-alcoholic fatty liver model and production process of high-fat feed
  • High-fat feed for inducing obesity and non-alcoholic fatty liver model and production process of high-fat feed
  • High-fat feed for inducing obesity and non-alcoholic fatty liver model and production process of high-fat feed

Examples

Experimental program
Comparison scheme
Effect test

preparation example

[0032] A high-fat feed for inducing obesity and non-alcoholic fatty liver model, consisting of the following raw materials in parts by weight:

[0033] 31.66 parts of lard, 24.55 parts of casein, 15.15 parts of maltodextrin, 8.89 parts of sucrose, 2 parts of fructose, 6.46 parts of cellulose, 3.9 parts of L-cystine, 0.3 parts of methionine, 3.23 parts of soybean oil, 2.13 parts of potassium citrate 1.68 parts of calcium hydrogen phosphate, 0.71 parts of calcium carbonate, 0.26 parts of choline bitartrate, 1.29 parts of vitamin mixture, and 1.29 parts of mineral mixture;

[0034] The vitamin mixture consists of the following raw materials in parts by weight:

[0035] 0.08 part of vitamin A acetate, 0.15 part of vitamin D3, 1.2 part of vitamin E acetate, 0.008 part of menadione sodium bisulfite, 0.2 part of biotin, 0.1 part of cyanocobalamin, 0.02 part of folic acid, 0.3 part of niacin, 0.16 parts of calcium pantothenate, 0.07 parts of pyridoxine hydrochloride, 0.06 parts of ri...

experiment example

[0047] Adopt the high-fat feed involved in the present invention to induce obesity and the verification test data of fatty liver in mice as follows:

[0048] (1) Experimental design

[0049] Thirty-two C57BL / 6J mice aged about 6 weeks were selected, and after 7 days of pre-feeding, the mice were randomly divided into 2 groups with 16 repetitions in each group to ensure that there was no significant difference in body weight between groups (ANOVA analysis). The control group was fed with low-fat feed, and the induction group was fed with the high-fat feed prepared in Example 1. The feeding test period was 12 weeks. During the test period, ad libitum feeding and drinking were ensured, room temperature (23° C.) was maintained, and single cages were raised. During the experiment, weighing was performed every 3 days, litter was replaced once, and drinking water was replaced once, and the food intake of mice was recorded every day.

[0050](Contrast low-fat feed formula: 47.68 part...

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Abstract

The invention discloses a high-fat feed for inducing obesity and a non-alcoholic fatty liver model and a production process of the high-fat feed. The high-fat feed is prepared from lard oil, casein, maltodextrin, cane sugar, fructose, cellulose, L-cystine, methionine, soybean oil, potassium citrate, calcium hydrophosphate, calcium carbonate, choline tartrate, a vitamin mixture and a mineral mixture. The feed is close to a human diet mode, an induced obese animal model is high in repetition rate, obesity and fatty liver characterization is remarkable, and the feed is mature in production process, low in cost and capable of being popularized on a large scale.

Description

technical field [0001] The invention belongs to the field of functional feed for animal experiments, and in particular relates to a high-fat feed for inducing obesity and non-alcoholic fatty liver models and a production process thereof. Background technique [0002] With the rapid development and improvement of the economy and productivity, people's living standards are also constantly improving. The daily diet changed from carbohydrate-based to high-fat and high-protein. The deepening of industrialization has further reduced manual labor. Excessive fat intake and the reduction of physical labor have resulted in the high incidence of obesity in today's society. The "Nutrition and Chronic Disease Status Report of Chinese Residents (2020)" shows that more than 50% of Chinese adult residents are overweight and obese, nearly 20% of children and adolescents aged 6 to 17, and 10% of children under 6 years old. [0003] Obesity poses a non-negligible threat to human health. Obe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K20/158A23K20/147A23K20/163A23K20/142A23K20/105A23K20/26A23K20/174A23K20/20A23K40/20A23K40/10A23K50/50
CPCA23K20/158A23K20/147A23K20/163A23K20/142A23K20/105A23K20/26A23K20/174A23K20/30A23K40/20A23K40/10A23K50/50
Inventor 伍树松胡睿智李柏珍谭继君陈波袁旭鹏
Owner HUNAN AGRICULTURAL UNIV
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