Medicine for preventing and treating nocardia disease and application thereof

A nocardiosis and drug technology, which is applied in the field of prevention and treatment of nocardiosis by extracts of Chinese herbal medicines and their active ingredients, which can solve problems such as drug resistance, environmental and food safety issues, and long treatment courses, and achieve low The effect of drug resistance and broad application prospects

Active Publication Date: 2022-03-22
西北农林科技大学深圳研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the main treatment method is antibiotics, but due to the long course of treatment, it is easy to lead to the emergence of drug resistance, and antibi

Method used

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  • Medicine for preventing and treating nocardia disease and application thereof
  • Medicine for preventing and treating nocardia disease and application thereof
  • Medicine for preventing and treating nocardia disease and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0022] Example 1

[0023] The present examples illustrate the measurement of the thick and phenolic and phenoliocyte of the active ingredient thereof to the minimum antibacterial concentration (MIC) of Norcocchard bacteria.

[0024] (1) Experimental strain

[0025] Purification from the large mouth of Norcocci's large mouth, purification was separated from 1st Nagcuria, and identified by molecular biological identification and physiological and biochemical as the n.seriolaeso, preserved in Northwest Agricultural and Forestry University. Aquatic Science Laboratory.

[0026] (2) Bacterial culture culture

[0027] Configuring soytezolaum liquid medium (TSB): Tested trypsin 3.0g, sodium sodium 胨 1.0 g, sodium chloride, and 200 ml of distilled water, heat dissolved to cool to room temperature, and adjusted pH to 7.3 by 5 mol / L hydrochloric acid. High pressure of 121 ° C for 15 minutes, to be cooled to room temperature.

[0028] In vicinted in the vicinity of the ultra-clean alcohol l...

Example Embodiment

[0039] Example 2

[0040] This example illustrates the thickness of the martial arts, the phenol and the porp and phenol, which is used as a feed additive to feeding the large mouth, prevent the effect of Norcocci.

[0041] (1) Feed Preparation

[0042] We can weigh a certain amount of mougu extract, 50% ethanol dissolution, and spray evenly spray to the basic feed (purchased from Guangdong Yuehai Feed Co., Ltd., California] special feed, particle diameter of 2.5mm, excluding the thickness and its active ingredients The thickness and phenolic phenolic is 250, 500, 1000 mg / kg (thick extract / feed), respectively.

[0043] Weigh a certain amount of thick and phenol, ennovia, and make high-low dose-containing feed in the same way, the drug content is 400, 200, 100 mg / kg (thick and rumor extract / feed). After the ethanol is naturally volatilized, 4 ° C is stored at 4 ° C.

[0044] (2) Experimental method

[0045] Choose a healthy large mouth, average weight 20 ± 2.0g, randomly di...

Example Embodiment

[0049] Example 3

[0050] This embodiment will be mounted and the active ingredient is soapped, and the thickness is made into an injection, and the effect of preventing the infection of Norcocci is determined.

[0051] (1) Pharmaceutical solution configuration

[0052] The mounted extract, moug, and porp phenol, Enovoroxacin separately configured a concentration of 5 mg / ml of injections with DMSO solution.

[0053] (2) Experimental method

[0054] Choosing a healthy blacklogen, average body weight 30 ± 3.4 g, randomly divided into control group, negative control group and drug treatment group (Enovard, magnoli extract, moug, and phenol). Both the drug treatment group set up a low medium and three concentration treatment groups, each three parallel, each parallel 20 tail. The negative control group was injected with 50 μl of a sterile PBS solution, the control group and the drug treatment group were injected with 50 μl of the monocity concentration of Norcocci PBS suspension. Th...

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Abstract

The invention provides a nocardia antibacterial composition. The effective components of the composition for inhibiting nocardia comprise a mangnolia officinalis extract, or a combination of the mangnolia officinalis extract and magnolol, or a combination of the mangnolia officinalis extract and honokiol, or a combination of the mangnolia officinalis extract, the magnolol and the honokiol. The other nocardia antibacterial composition comprises effective components of magnolol, or honokiol, or a combination of magnolol and honokiol. The invention discloses the inhibition activity of the mangnolia officinalis extract and the active component magnolol and honokiol thereof on nocardia for the first time, has the advantages of high efficiency, safety, no residue, easiness in degradation, low drug resistance and the like, and provides a new treatment method and way for nocardia infection of fishes (aquatic animals).

Description

technical field [0001] The invention belongs to the technical field of aquaculture and relates to the prevention and treatment of nocardiosis, in particular to the prevention and treatment of nocardiosis by extracts of Chinese herbal medicines and active components thereof. Background technique [0002] Nocardiosis is a zoonotic chronic infectious disease caused by Nocardia, which poses a great threat to aquaculture and aquatic product safety. Nocardia is a Gram-positive bacterium widely distributed in soil and water environments. The Nocardia that attack fish mainly include Nocardia seriolae, Nocardia asteroides ( N. asteroides) and Nocardia salmonicida (N. salmonicida). Among them, Nocardia spp. is the most common fish pathogenic bacteria, which can cause more than 100000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000 into largemouth bass, snakehead, tilapia and maricultured yellowtail, pomfret, sea bream, large yellow croaker an...

Claims

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Application Information

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IPC IPC(8): A61K36/575A61K31/05A61P31/04A23K10/30A23K20/111A23K50/80
CPCA61K36/575A61K31/05A61P31/04A23K10/30A23K20/111A23K50/80A61K2300/00Y02A40/81
Inventor 王高学凌飞姜海峰仁宗易张念锟
Owner 西北农林科技大学深圳研究院
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