Degradable pure magnesium or magnesium alloy oral biological barrier membrane and preparation method thereof

A bio-barrier and magnesium alloy technology, which can be used in manufacturing tools, drug delivery, pharmaceutical formulations, etc., can solve the problems of too fast degradation of magnesium alloy oral biofilm and insufficient bone tissue integration effect, and achieve the purpose of inhibiting epithelial cells or hoof tissue Proliferation, improve the uniformity of degradation, eliminate the effect of internal stress

Active Publication Date: 2022-03-25
INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a biodegradable pure magnesium or magnesium alloy oral bio-barrier film and its preparation method to solve the problems of too fast degradation of magnesium alloy oral biofilm and insufficient bone tissue integration effect

Method used

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  • Degradable pure magnesium or magnesium alloy oral biological barrier membrane and preparation method thereof
  • Degradable pure magnesium or magnesium alloy oral biological barrier membrane and preparation method thereof
  • Degradable pure magnesium or magnesium alloy oral biological barrier membrane and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0035] In this embodiment, the preparation method of the degradable magnesium alloy oral biological barrier film comprises the following steps:

[0036] Step 1. The magnesium alloy sheet containing 2% Zn and 0.5% Nd is rolled three times and vacuum annealed at 200° C. for 2 hours to obtain a magnesium alloy foil with a thickness of 200 μm.

[0037] Step 2. Prepare circular holes arranged in an array and evenly distribute in the magnesium alloy film by laser processing, such as figure 1 shown in (a).

[0038] Step 3: Preforming the magnesium alloy film into a U-shape with a hard alloy mold, and then performing vacuum stress relief annealing at 200° C. for 1 hour to eliminate internal stress.

[0039] Step 4: Polyurethane is sprayed onto the inner surface of the magnesium alloy film to form a protective layer. Adopt concentration to be that 40% (mass fraction) in the hydrofluoric acid room temperature immersion 12h prepare smooth surface magnesium fluoride coating, thickness i...

Embodiment 2

[0043] In this embodiment, the preparation method of the degradable magnesium alloy oral biological barrier film comprises the following steps:

[0044] Step 1. The magnesium alloy thin plate containing Zn2% and Nd0.5% is rolled through four passes and vacuum annealed at 200° C. for 2 hours to obtain a magnesium alloy foil with a thickness of 200 μm.

[0045] Step 2. Prepare circular holes arranged in an array and evenly distribute in the magnesium alloy film by laser processing, such as figure 1 shown in (a).

[0046] Step 3: Preforming the magnesium alloy film into a U-shape with a hard alloy mold, and then performing vacuum stress relief annealing at 200° C. for 1 hour to eliminate internal stress.

[0047] Step 4: Polyurethane is sprayed onto the inner surface of the magnesium alloy film to form a protective layer. Adopt concentration to be that 40% (mass fraction) in the hydrofluoric acid room temperature immersion 12h prepare smooth surface magnesium fluoride coating, ...

Embodiment 3

[0051] In this embodiment, the preparation method of the degradable magnesium alloy oral biological barrier film comprises the following steps:

[0052] Step 1. The magnesium alloy sheet containing Zn2% and Nd0.5% is rolled five times and vacuum annealed at 200° C. for 2 hours to obtain a magnesium alloy foil with a thickness of 200 μm.

[0053] Step 2. Prepare S-shaped holes arranged in an array and evenly distribute in the magnesium alloy film by laser processing, such as figure 1 shown in (b).

[0054] Step 3: Preforming the magnesium alloy film into a U-shape with a hard alloy mold, and then performing vacuum stress relief annealing at 200° C. for 1 hour to eliminate internal stress.

[0055] Step 4: Polyurethane is sprayed onto the inner surface of the magnesium alloy film to form a protective layer. Adopt concentration to be that 40% (mass fraction) in the hydrofluoric acid room temperature immersion 12h prepare smooth surface magnesium fluoride coating, thickness is 2...

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Abstract

The invention relates to the field of biomedical materials, in particular to a degradable pure magnesium or magnesium alloy oral biological barrier membrane and a preparation method thereof. According to the method, the hole pattern structure design, the pre-forming process and the vacuum annealing treatment are combined, so that the deformation uniformity is improved, the internal stress generated by deformation is eliminated, and the degradation uniformity is greatly improved. A one-film double-coating special surface treatment method is adopted, so that one side of the pure magnesium or magnesium alloy film has a smooth surface, and adhesion and proliferation of epithelial cells or hoof forming tissues are inhibited; on the other hand, a rough surface with an osteogenesis function is obtained, and growth of bone tissues is promoted. In addition, the one-film double-coating further has the asymmetric degradation characteristic, and the corrosion resistance of the smooth surface is more excellent than that of the rough surface; the pure magnesium or magnesium alloy membrane is asymmetrically degraded, so that a stable interface can be obtained on the outer layer of the barrier membrane to shield epithelial cells or hoofing tissues, and meanwhile, the inner layer releases bone ions through controllable degradation to improve bone tissue repair and integration effects.

Description

Technical field: [0001] The invention relates to the field of biomedical materials, in particular to a biodegradable pure magnesium or magnesium alloy oral cavity biological barrier film and a preparation method thereof. Background technique: [0002] When the alveolar bone is insufficient due to inflammation or other reasons, it is necessary to increase the bone mass before oral implant restoration. Guided bone regeneration (GBR) is a common method to solve this problem. Among them, GBR technology refers to the use of oral shielding membrane to obtain the physical space for bone tissue repair, avoiding epithelial cells or hoof tissue, because of faster growth, the bone tissue space is occupied and bone tissue repair is inhibited. The use of oral biobarrier membranes can guide bone tissue regeneration and improve repair results. [0003] An ideal barrier membrane needs to obtain the following properties: excellent biocompatibility, no biotoxicity; good shielding effect, pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/10A61L31/08A61L31/14C22F1/02C22F1/06C21D9/46C25D11/30C23C26/00C23C22/00
CPCA61L31/022A61L31/10A61L31/088A61L31/086A61L31/148A61L31/14C22F1/02C22F1/06C21D9/46C23C26/00C25D11/026C25D11/30C23C22/00A61L2400/18A61L2420/02A61L2300/602A61L2300/412A61L2300/606A61L2420/08C08L69/00C08L75/04
Inventor 王青川谭丽丽杨柯
Owner INST OF METAL RESEARCH - CHINESE ACAD OF SCI
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