Composite coating with adjustable release performance of active ingredients and preparation method of composite coating

An active ingredient and composite coating technology, which is applied in the field of composite coatings with adjustable release performance of active ingredients and their preparation, can solve the problems of small influence of active ingredients and difficulty in construction, and achieves small influence, guaranteed safety, and preparation method. simple effect

An active ingredient and composite coating technology, which is applied in the field of composite coatings with adjustable release performance of active ingredients and their preparation, can solve the problems of small influence of active ingredients and difficulty in construction, and achieves small influence, guaranteed safety, and preparation method. simple effect

CN114246993APending Publication Date: 2022-03-29NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI +1
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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Use 200mL 50% ethanol aqueous solution as a solvent, add 15g polylactic acid (particle size 30-100μm) and 5g polycaprolactone (particle size 15-55μm) to obtain a mixed polymer suspension, then add 0.5g gentamicin sulfate Mycin, to prepare a mixed solution.

[0039] (2) Substrate surface cleaning: the substrate is made of stainless steel sheets, cleaned with acetone, alcohol, and deionized water in sequence, and then dried with nitrogen gas for later use; substrate surface roughening: the cleaned substrate surface is roughened by sandblasting, In order to increase the surface roughness of the substrate and improve the bonding strength of the coating, the parameters of the sandblasting process are: air pressure 0.8MPa, sandblasting time 20s, and the number of sand shot used for sandblasting is 50 mesh;

[0040] (3) Utilize the flame spraying process to spray the mixed solution of step (1) on the substrate surface after processing, and the condition of flame spraying i...

Embodiment 2

[0042] (1) Use 200mL of 50% ethanol aqueous solution as solvent, add 5g polylactic acid (particle size 30-100 μm) and 15g polycaprolactone (particle size 15-55 μm) to obtain a mixed polymer suspension, and then add 0.5g sodium sulfate Damycin, to prepare a mixed solution.

[0043](2) Cleaning of the substrate surface: the substrate is made of glass, washed with acetone, alcohol, and deionized water in sequence, and then blown dry with nitrogen for use; roughening of the substrate surface: the surface of the substrate after cleaning is roughened by sandblasting, to Increase the surface roughness of the substrate and improve the bonding strength of the coating. The parameters of the sandblasting process are: air pressure 0.8MPa, sandblasting time 20s, and the number of sand shot used for sandblasting is 50 mesh;

[0044] (3) Utilize the flame spraying process to spray the mixed solution of step (1) on the substrate surface after processing, and the condition of flame spraying is...

Embodiment 3

[0046] (1) Using 200mL 50% ethanol aqueous solution as solvent, add 10g polylactic acid (particle size 30-100μm) and 10g perfluoropropyl perfluorovinyl ether-polytetrafluoroethylene copolymer (particle size 30-100μm) to get mixed Add 0.5 g of gentamicin sulfate to the polymer suspension to prepare a mixed solution.

[0047] (2) Substrate surface cleaning: the substrate is made of stainless steel sheets, cleaned with acetone, alcohol, and deionized water in sequence, and then dried with nitrogen gas for later use; substrate surface roughening: the cleaned substrate surface is roughened by sandblasting, In order to increase the surface roughness of the substrate and improve the bonding strength of the coating, the parameters of the sandblasting process are: air pressure 0.8MPa, sandblasting time 20s, and the number of sand shot used for sandblasting is 50 mesh;

[0048] (3) Utilize the flame spraying process to spray the mixed solution of step (1) on the substrate surface after ...

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Abstract

The invention discloses a preparation method of a composite coating with adjustable release performance of active ingredients. The preparation method comprises the following steps: (1) preparing a mixed solution from at least two macromolecules and at least one active ingredient; (2) cleaning and roughening the surface of the matrix; and (3) spraying the mixed solution obtained in the step (1) on the surface of the treated matrix by using a flame spraying process to prepare the composite coating with the adjustable release performance of the active components, the active components comprise an antibacterial agent, an anticoagulant, an antiplatelet drug, an angiogenesis inhibitor, a hemostatic, an antitumor agent, an immunosuppressive agent and an osteoinducer. The method is good in repeatability, high in safety and small in influence on the active ingredients, the problem that a solvent system between different macromolecules is difficult to construct is solved, the excellent characteristics of different macromolecules can be combined, and the prepared composite coating with the adjustable release performance of the active ingredients can achieve release of the active ingredients at different rates.

Description

technical field [0001] The invention relates to the technical field of composite coatings, in particular to a composite coating with adjustable release performance of active ingredients and a preparation method thereof. Background technique [0002] The lack of antibacterial, biological activity, and osteoinductivity of conventional medical materials greatly limits its application, so surface functional modification is usually required. There are many types of polymer materials, various mechanical properties, stable physical properties, and various biocompatibility, so they are widely used in the preparation of surface functional modification coatings. However, because the slow-release properties of different polymer coatings are very different, and the solubility properties in different solvents are different, the conventional blending and compounding method after dissolution is severely restricted, and it is difficult to release a wide variety of polymer materials. Extens...

Claims

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Application Information

Patent Timeline
29 Mar 2022
Publication
CN114246993A
IPC
A61L31/16; A61L31/10; B05D7/24; B05D1/08; B05D3/00
CPC
A61L31/16; A61L31/10; B05D7/24; B05D1/08; B05D3/002; A61L2300/404; A61L2300/406; A61L2300/606
Inventors
张波涛; 潘永红